The Role of Brain Protein Phosphatases 1 and 2A in the Regulation of Microtubule Assembly

  • Hideyuki Yamamoto
  • Yoshiki Saitoh
  • Kohji Fukunaga
  • Eishichi Miyamoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)


Protein phosphatase C was purified from bovine brain and was considered to consist of 10 and 90 %, respectively, of the catalytic subunits of protein phosphatases 1 and 2A on the basis of the effects of ATP and inhibitor-2. We investigated the dephosphorylation of microtubule proteins and the autophosphorylated Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) by protein phosphatase C.


Protein Phosphatase Catalytic Subunit Bovine Brain Dependent Protein Kinase Microtubule Assembly 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Hideyuki Yamamoto
    • 1
  • Yoshiki Saitoh
    • 1
  • Kohji Fukunaga
    • 1
  • Eishichi Miyamoto
    • 1
  1. 1.Department of PharmacologyKumamoto University Medical SchoolKumamotoJapan

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