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Characterization of the Calmodulin-Binding Domain of Calcineurin Deduced from a Complementary DNA Clone

  • Chapter
Calcium Protein Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 255))

Abstract

An essential role for Ca2+- and calmodulin (CaM)-dependent events in neuronal transduction is suggested by the high amounts of this Ca2+binding protein in the central nervous system. Further, several enzymes that it modulates (adenylate cyclase, cyclic nucleotide phosphodiesterase, protein kinase and the phosphoprotein phosphatase, calcineurin) have their highest concentrations in the brain, implicating Ca2+- regulated cyclic nucleotide and phosphoprotein metabolism in intracellular signaling. Importantly, the multifunctional CaM-dependent protein kinase is known to be the major protein in post-synaptic densities1,2, consistent with a critical function for phosphoproteins in neurotransmission

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Author information

Authors and Affiliations

  1. Section on Immunology, Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, USA

    Randall L. Kincaid

  2. Molecular Neurogenetics Section Clinical Neurosciences Branch, National Institute of Mental Health, USA

    Brian M. Martin

  3. Alcohol, Drug Abuse, and Mental Health Administration, Bethesda, MD, 20892, USA

    Brian M. Martin

Authors
  1. Randall L. Kincaid
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  2. Brian M. Martin
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Editor information

Editors and Affiliations

  1. Nagoya University, Nagoya, Japan

    H. Hidaka

  2. Swiss Federal Institute of Technology, Zurich, Switzerland

    E. Carafoli

  3. Baylor College of Medicine, Houston, Texas, USA

    A. R. Means

  4. Mie University School of Medicine, Mie, Japan

    T. Tanaka

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© 1989 Plenum Press, New York

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Kincaid, R.L., Martin, B.M. (1989). Characterization of the Calmodulin-Binding Domain of Calcineurin Deduced from a Complementary DNA Clone. In: Hidaka, H., Carafoli, E., Means, A.R., Tanaka, T. (eds) Calcium Protein Signaling. Advances in Experimental Medicine and Biology, vol 255. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5679-0_38

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  • DOI: https://doi.org/10.1007/978-1-4684-5679-0_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5681-3

  • Online ISBN: 978-1-4684-5679-0

  • eBook Packages: Springer Book Archive

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