Activation of Rabbit Skeletal Muscle Myosin Light Chain Kinase by Calmodulin- A Mechanistic Overview

  • Peter J. Kennelly
  • Melissa Starovasnik
  • Edwin G. Krebs
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)


The myosin light chain kinases [MLCK, E.C.] are a family of tissue-specific isozymes which share as their substrate the phosphoryl- or P-light chain.component of myosin. Distinct forms of MLCK have been isolated from smooth, skeletal, and cardiac muscle. The enzyme appears to be ubiquitous, with non-muscle MLCK envisaged as being very similar, if not identical, to the smooth muscle isozyme (For a review see (43)).


Myosin Light Chain Kinase Alpha Helix Phosphorylase Kinase Autoinhibitor Domain Partial Proteolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Peter J. Kennelly
    • 1
  • Melissa Starovasnik
    • 2
  • Edwin G. Krebs
    • 1
    • 2
    • 3
  1. 1.Howard Hughes Medical InstituteUniversity of WashingtonSeattleUSA
  2. 2.Department of BiochemistryUniversity of WashingtonSeattleUSA
  3. 3.Department of PharmacologyUniversity of WashingtonSeattleUSA

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