Abstract
Adenine phosphoribosyltransferase (APRT, EC 2.4.2.7) and hypoxanthine phosphoribosyltransferase (HPRT, EC 2.4.2. 8) are purine salvage enzymes and catalyze the formation of adenosine monophosphate (AMP) and inosine monophosphate (IMP) from adenine, hypoxanthine and phosphoribosyl-pyrophosphate (PRPP).
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References
M. Leach and W. A. Nyhan, A familial disorder of uric acid metabolism and central nervous system function. Am J. Mecl. 36: 561–570 (1964).
P. Cartier, M. Hamet and J. Hamburger, Une nouvelle maladie metabolique: le deficit complet en adenine phosphoribosyltranferase avec lithiase de 2, 8-dihydroxyadenine. CR Acad Sci [D](Paris) 279: 883–886 (1974).
W. N. Kelley, F. M. Rosenbloom, J. F. Hederson and J. E. Seegmiller. A specific enzyme detect in gout associated with over-production of uric acid. Proc. Natl Acad. Sci USA 57: 1735–1739 (1967).
H. Kizaki and T. Sakurai. A micro-assay method for hypoxanthine-guanine and adenine phosphoribosyl-transferase. Anal. Biochem., 72: 49–56 (1976).
L. A. Johnson, R. B. Gordon and B. T. Emmerson. Adenine phosphoribosyltransferase: a simple spectrophotometric assay and the incidence of mutation in the normal population. Biochem. Genet., 15: 265–272 (1977).
H. J. Rylance, R. C. Wallance and G. Nuki, Hypoxanthine-guanine phosphoribosyltransferase: assay using high performance chromatography. Clin. Chim. Acta., 121: 159–165 (1982).
T. H. Fox, S. Lacroix, G. Planet and M. Moore, Partial deficiency of adenine phosphoribosyltransferase in man. Medicine, 148: 203–207 (1985).
T. Kojima, T. Nishina, M. Kitamura, H. Yamanaka, N. Kamatani and K. Nishioka, High performance liquied Chromatographie assay of anenine phosphoribosyl-tranferase and hypoxanthine-guanine phosphoribosyltranferase activities in human erythrocytes. Jpn. J. Clin. Chem., 13: 15–22 (1984).
E. J. Van Kamoen and W. G. Zijlstra, Standardization of haemoglobinometry II: the hemoglobin cyanide method. Clin. Chim. Acta, 121: 159–165 (1961).
H. J. Rylance, R. C. Wallance and Nuki, Adenine phosphoribosyl tranferase: assay using high performance liquid chromatography. Clin. Chim. Acta, 148: 267–272 (1985).
T. Kamatani, F. Takeuchi, Y. Nishida, H. Yamanaka, K. Nishioka, K. Tatara S. Fujimori, K. Kaneko, I. Akaoka and Y. Tofuku, Severe impairment in adenine metabolism with a partial deficiency of adenine phosphoribosyl-transferase. Metabolism, 34: 164–168 (1985).
P. Chiba, K. Zwiauer and M. M. Müller, Characterization of an adenine phosphoribosyltransferase deficincy. Clin. Chim. Acta, 172: 144–148 (1988).
L. A. Johnson, R. B. Cordon and B. T. Emmerson, Hypoxanthine-guanine phosphoribosyltranferase: a simple spectrophotometric assay. Clin. Chim. Acta, 80: 203–207 (1977).
W. N. Kelley, M. L. Greene, F. M. Rosenbloom, J.F. Henderson and J. E. Seeegmiller, Hypoxanthine-guanine phosphoribosyltransferase deficincy in gout. Ann, Intern Med., 70: 155–206 (1969).
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© 1989 Plenum Press, New York
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Nishina, T., Sakuma, R., Kojima, T., Kiyamura, M., Kamatani, N., Nishioka, K. (1989). High-Performance Liquid Chromatographic Method for Simultaneous Screening of the Deficiencies of APRT and HPRT. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_9
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DOI: https://doi.org/10.1007/978-1-4684-5673-8_9
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