Renal Excretion of Purine Bases — Effects of Probenecid, Benzbromarone and Pyrazinamide
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The renal transport mechanism(s) of oxypurines has been investigated by many workers1–4. As a result, it has been demonstrated that a mechanism for both renal reabsorption and secretion of oxypurines is present in the human. However, a transport mechanism for oxypurines has not yet been accurately or reliably hypothesized, lacking the base of many investigations. We therefore conducted investigations on the renal transport mechanism of oxypurines by employing uricosuric agents (probenecid and benzbromarone) and pyrazinamide.
KeywordsUric Acid Transport Mechanism Xanthine Oxidase Renal Excretion Control Period
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