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Purine and Pyrimidine Metabolism in Man VI pp 277–281Cite as

Renal Excretions of Oxypurinol and Oxypurines — Effects of Pyrazinamide, Probenecid and Benzbromarone

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 253A))

Abstract

In normal persons and gouty subjects, allopurinol is mainly converted to oxypurinol by xanthine oxidase and oxypurinol is then excreted unchanged by the kidney1. The concentration of serum oxypurinol is directly related to the renal clearance of oxypurinol2, which is increased or decreased under various conditions2, 3. While the renal handling of oxypurinol seems to be similar to that of uric acid 2, 4, the renal transport mechanism(s) of oxypurinol has not yet been clearly elucidated. Therefore, in this work we studied the renal handling of oxypurinol together with oxypurines using uricosuric agents (probenecid and benzbromarone) and pyrazinamide which affect the renal transport of uric acid.

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References

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Authors and Affiliations

  1. The Third Department of Internal Medicine, Hyogo College of Medicine, Mukogawa 1-1, Nishinomiya, Hyogo 663, Japan

    Tetsuya Yamamoto, Yuji Moriwaki, Sumio Takahashi, Toshikazu Hada & Kazuya Higashino

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  1. Tetsuya Yamamoto
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  2. Yuji Moriwaki
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  3. Sumio Takahashi
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  4. Toshikazu Hada
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  5. Kazuya Higashino
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Editor information

Editors and Affiliations

  1. Mikanagi Gotanda Hospital, Tokyo, Japan

    Kiyonobu Mikanagi

  2. Tokyo Women’s Medical College, Tokyo, Japan

    Kusuki Nishioka

  3. University of Michigan Medical Center, Ann Arbor, Michigan, USA

    William N. Kelley

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© 1989 Plenum Press, New York

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Yamamoto, T., Moriwaki, Y., Takahashi, S., Hada, T., Higashino, K. (1989). Renal Excretions of Oxypurinol and Oxypurines — Effects of Pyrazinamide, Probenecid and Benzbromarone. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_46

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  • DOI: https://doi.org/10.1007/978-1-4684-5673-8_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5675-2

  • Online ISBN: 978-1-4684-5673-8

  • eBook Packages: Springer Book Archive

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