Activity and Effect of Purine Metabolizing Enzymes in the Digestive Tract

  • Y. Nishida
  • Y. Hoshihara
  • T. Miyamoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)


The relationship between dietary factors and the prevalence of gout is well known. During World Wars I and II, acute gouty arthritis was observed to be uncommon in Europe. In Japan, recently, gout is becoming more common perhaps due to an increased intake of protein and purines. Many gouty patients eat food rich in purines and excrete increased urinary urate. It seems that dietary purines may be easily absorbed from the intestinal tract and may be degraded to uric acid in the liver.


Uric Acid Xanthine Oxidase Adenosine Deaminase Purine Nucleoside Phosphorylase Xanthine Oxidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D.A. Hopkinson, P.J.L. Cook, H. Harris, Further data on the adenosine deaminase (ADA) poly-morphism and a report of a new phenotype. Ann Hum Genet 32, 361, (1969).PubMedCrossRefGoogle Scholar
  2. 2.
    H.M. Kalckar, Differential spectrophotometry of purine compounds by means of specific enzymes. J Biol Chem 167, 429, (1947).PubMedGoogle Scholar
  3. 3.
    W.T. Caraway, H. Marable, Comparison of carbonate and uricasecarbonate methods for the determination of uric acid in serum. Clin Chem 12, 18, (1960).Google Scholar
  4. 4.
    G. Poste, D. Papahadjopoulos, Lipid vesicles as carriers for introducing materials into cultured cells: Influence of vesicle lipid composition on mechanism(s) of vesicle incorporation into cells. Proc Natl Acad Sci 73, 1603, (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    S. Davis, A. Abuchowski, Y.K. Park, F.F. Davis, Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol. Clin Exp Immunol 46, 649, (1981).PubMedGoogle Scholar
  6. 6.
    H.M. Patel, B.E. Ryman, Oral administration of insulin by encapsulation within liposomes. FEBS Lett 62, 60, (1976).PubMedCrossRefGoogle Scholar
  7. 7.
    G. Dapergolas, G. Gregoriadis, Hypoglycaemic effect of liposome-entrapped insulin administered intragastrically into rats. Lancet 2, 824, (1976).PubMedCrossRefGoogle Scholar
  8. 8.
    J.H. Fendler, A. Romero, Liposomes as drug carriers. Life Sci 20, 1109, (1977).PubMedCrossRefGoogle Scholar
  9. 9.
    M. Finkeistein, G. Weissmann, The introduction of enzymes into cells by means of liposomes. J Lipid Res 19, 289, (1978).Google Scholar
  10. 10.
    D.S. Deshmukh, W.D. Bear, H. Brockerhoff, Can intact liposomes be absorbed in the gut. Life Sci 28, 239, (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Y. Nishida
    • 1
  • Y. Hoshihara
    • 1
  • T. Miyamoto
    • 1
  1. 1.Department of Medicine and Physical TherapyUniversity of Tokyo School of MedicineTokyoJapan

Personalised recommendations