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Can Risk Scores for Vascular Disease in Gout Patients be Improved?

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Purine and Pyrimidine Metabolism in Man VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 253A))

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Abstract

Since reductions have occurred in mortality from ischaemic heart disease in the USA (1) and in the United Kingdom (2) concurrently with reductions in consumption of tobacco and dairy produce, increased intake of polyunsaturated fats and awareness of the benefits of regular exercise, it seems reasonable to attribute the declining mortality at least in part to the effects of these changes in lifestyle.

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References

  1. W. J. Walker, 1977, New England Journal of Medicine, 297: 163–5.

    Article  PubMed  CAS  Google Scholar 

  2. C. du V. Florey, R. J. W. Melia and S. C. Darby, 1978, Changing mortalit from ischaemic heart disease in Great Britain 1968-76. Br. Med. J., 1: 635–7.

    Article  Google Scholar 

  3. F. Fidanza, 1972, Epidemiological evidence for the fat theory. Proc. Nutr. Soc., 31: 317–21.

    Article  PubMed  CAS  Google Scholar 

  4. B. Lewis, J. I. Mann and M. Mancini, 1986, Reducing the risks of coronary heart disease in individuals and in the population. Lancet, i: 956

    Article  Google Scholar 

  5. P. Puska, J. Tuomilehto, J. Salonen, L. Neittaanmäki, J. Maki, J. Virtamo, A. Nissinen, K. Koskela and T. Takalo, 1979, Changes in coronary risk factors during comprehensive five year community programme to control cardiovascular disease (North Karelia project). Br. Med. J., 2: 1173–78.

    Article  PubMed  CAS  Google Scholar 

  6. L. L. Basta, C. Williams, J. M. Kioschos and A. A. Spector, 1976, Regression of atherosclerotic stenosing lesions of the renal arteries and spontaneous cure of systemic hypertension through control of hyperlipidaemia. Am. J. Med., 81: 420–3.

    Article  Google Scholar 

  7. R. Barndt, D. H. Blankenhorn, D. W. Crawford and S. H. Brooks, 1977, Regression and Progression of Early Femoral Atherosclerosis in Treated Hyperlipoproteinaemic Patients. Ann. Intern. Med., 86: 139–146.

    PubMed  Google Scholar 

  8. L. G. Darlington, J. Slack and J. T. Scott, 1983, Vascular mortality in patients with gout and in their families. Ann. Rheum. Dis, 42: 270–73.

    Article  PubMed  CAS  Google Scholar 

  9. A. P. Hall, 1965, Correlations among hyperuricaemia, hypercholesterol-aemia, coronary disease and hypertension. Arthr. Rheum., 8: 846–52

    Article  CAS  Google Scholar 

  10. B. T. Nobbs, J. M. Smith and A. W. Walker, 1977, Enzymic determination of plasma cholesterol on discrete automatic analysers. Clinical Chimica Acta, 79: 391–7.

    Article  CAS  Google Scholar 

  11. P. Fossati and L. Prencipe, 1982, Serum triglycerides determined colori metrically with an enzyme that produces hydrogen peroxide. Clin. Chem. 28: 2077–80.

    PubMed  CAS  Google Scholar 

  12. M. Eggstein and F. H. Kreutz, 1966, Eine neue Bestimmung der Neutralfette I. Klin. Wschr., 44: 262–267.

    Article  PubMed  CAS  Google Scholar 

  13. W. B. Kannel, T. R. Dawber, G. D. Friedman, W. E. Glennon and P. M. McNamara, 1964, Risk Factors in Coronary Heart Disease. An Evaluation of Several Serum Lipids as Predictors of Coronary Heart Disease. The Framing-ham Study. Ann. Intern. Med., 61: 888–899.

    PubMed  CAS  Google Scholar 

  14. P. Williams, D. Robinson and A. Bailey, 1979, High-Density Lipoprotein and Coronary Risk Factors in Normal Men. Lancet, i: 72–75.

    Article  Google Scholar 

  15. J. Slack, N. Noble, T. W. Meade, W. R. S. North, 1977, Lipid and lipoprotein concentrations in 1604 men and women in working populations in north-west London. Br. Med. J., 2: 353–56

    Article  PubMed  CAS  Google Scholar 

  16. S. J. Pocock, A. G. Shaper, A. N. Phillips, M. Walker, T. P. Whitehead, 1986, High density lipoprotein cholesterol is not a major risk factor for ishcaemic heart disease in British men. Br. Med. J., 292: 515–19.

    Article  CAS  Google Scholar 

  17. J. L. Beaumont, L. A. Carlson, G. R. Cooper, Z. Fejfar, D. S. Fredrick-son, T. Strasser, 1970, Classification of hyperlipidaemias and hyperlipopro-teinaemias. Bulletin of the World Health Organisation, 43: 891–915.

    CAS  Google Scholar 

  18. L. R. Krasno and G. J. Kidera, 1972, Clofibrate in Coronary Heart Disease. J.A.M.A., 219: 845–51

    Article  PubMed  CAS  Google Scholar 

  19. L. A. Carlson, M. Danielson, I. Ekberg, B. Klintemar and G. Rosenhamer, 1977, Reduction of myocardial reinfarction by the combined treatment with clofibrate and nicotinic acid. Atherosclerosis, 28: 81–6.

    Article  PubMed  CAS  Google Scholar 

  20. J. McMichael, 1979, Fats and atheroma: an inquest. Br. Med. J., 1: 173–175.

    Article  PubMed  CAS  Google Scholar 

  21. H. Geizerova, I. Gyarfas, K. G. Green, J. A. Heady et al, 1980, WHO Co-operative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow up. Lancet, ii: 379–85.

    Google Scholar 

  22. Lipid Research Clinics Coronary Primary Prevention Trials Results, 1984. J.A.M.A., 251: 351-64.

    Google Scholar 

  23. M. H. Frick, O. Elo, K. Haapa, O. P. Heinonen et al, 1987, Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil In Middle-Aged Men With Dyslipidaemia: Safety of Treatment, Changes in Risk Factors and Incidence of Coronary Heart Disease. N. Engl. J. Med., 317: 1237–45.

    Article  PubMed  CAS  Google Scholar 

  24. M. F. Oliver, H. Geizerova, I. Gyarfas, K. G. Green et al, 1978, A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Br. Heart J., 40: 1069–1118.

    Article  Google Scholar 

  25. I. C. Ononogbu, 1977, High density lipoprotein in ischaemic heart disease. Experientia, 33: 1063–64.

    Article  PubMed  CAS  Google Scholar 

  26. T. Gordon, W. P. Castelli, M. C. Hjortland, W. B. Kannel, T. R. Dawber, 1977, High Density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am. J. Med., 62: 707–714.

    CAS  Google Scholar 

  27. D. R. Jacobs Jr. (for the Lipid Research Clinics Follow Up Study), High density lipoprotein-cholesterol (HDL-C) and coronary heart disease (CHD), cardiovascular disease (CVD) and all cause mortality. Circulation, 72: 111–185.

    Google Scholar 

  28. S. Yaari, U. Gouldbourt, S. Even-Zohar, H. N. Neufeld, 1981, Association of Serum High Density Lipoprotein And Total Cholesterol With Total, Cardiovascular And Cancer Mortality In A 7-year Prospective Study of 10, 000 Men. Lancet, i: 1011–15.

    Article  Google Scholar 

  29. U. Goldbourt, E. Holtzman, H. N. Neufeld, 1985, Total and high density lipoprotein cholesterol in the serum and risk of mortality evidence of a threshold effect. Br. Med. J., 290: 1239–43.

    Article  CAS  Google Scholar 

  30. W. P. Castelli, J. T. Doyle, T. Gordon, C. G. Hames et al, 1977, Lancet ii: 153–5.

    Article  Google Scholar 

  31. L. G. Darlington and J. T. Scott, 1972, Plasma lipidlevels in gout. Ann. Rheum. Dis, 31: 487–489.

    Article  PubMed  CAS  Google Scholar 

  32. H. Mielants, E. M. Veys, A. de Weerdt, 1973, Gout and its relation to lipid metabolism I serum uric acid, lipid and lipoprotein levels in gout. Ann. Rheum. Dis., 32: 501–505.

    Article  PubMed  CAS  Google Scholar 

  33. T. Gibson and R. Grahame, 1974, Gout and hyperlipidaemia. Ann. Rheum. Dis., 33: 298–303.

    Article  PubMed  CAS  Google Scholar 

  34. L. G. Parlington, 1984, Lean dry gout patients in “Purine Metabolism in Man — IV. Clinical and Therapeutic Aspects; Regulatory Mechanisms”, C. H. M. M. de Bruyn, H. A. Simmonds and M. M. Muller eds., Plenum Press, New York.

    Google Scholar 

  35. S. Jiao, K. Kameda, Y. Matsuzawa and S. Tourui, 1986, Hyperlipoprotein-aemia in primary gout: hyperlipoproteinaemic phenotype and influence of alcohol intake and obesity in Japan. Ann. Rheum. Dis, 45: 308–313.

    Article  PubMed  CAS  Google Scholar 

  36. L. A. Carlson, L. E. Bottiger, 1972, Ischaemic heart disease in relation to fasting values of plasma triglycerides and cholesterol. Lancet, i: 865–8.

    Article  Google Scholar 

  37. R. G. Wilcox, 1978, Serum lipid concentrations and blood pressure in obese women. Br. Med. J., i: 1513–1515.

    Article  Google Scholar 

  38. D. A. Streja, E. Boyka and S. W. Rabkin, 1980, Changes in plasma high-density lipoprotein cholesterol concentration after weight reduction in grossly obese subjects. Br. Med. J., 281: 770–772.

    Article  PubMed  CAS  Google Scholar 

  39. W. B. Kannel, M. C. Hjortland, P. M. McNamara, T. Gordon, 1976, Menopause and risk of cardiovascular disease. The Framingham Study. Ann. Intern. Med., 85: 447–452.

    PubMed  CAS  Google Scholar 

  40. M. F. Oliver, G. S. Boyd, 1959. Lancet, ii: 690–694.

    Article  Google Scholar 

  41. The Coronary Drug Project. J.A.M.A., 214: 1303-1313.

    Google Scholar 

  42. Lancet Editorial, 1978, Oestrogens and atheroma. Lancet, ii: 508-10.

    Google Scholar 

  43. N. Hickey, R. Mulcahy, G. J. Bourke, I. Graham and K. Wilson-Davis, 1975, Study of coronary risk factors related to physical activity in 15171 men Br. Med. J., 3: 507–9.

    Article  PubMed  CAS  Google Scholar 

  44. J. N. Morris, J. W. Marr and D. G. Clayton, 1977, Diet and heart: a postscript. Br. Med. J., 2: 1307–14.

    Article  PubMed  CAS  Google Scholar 

  45. A. Lehtonen and J. Viikari, 1978, The Effect of vigorous physical activity at work on serum lipids with a special reference to serum high-density lipoprotein cholesterol. Acta. Physiol. Scan., 104: 117–121.

    Article  CAS  Google Scholar 

  46. S. Punsar, M. J. Karvonen, Physical activity and coronary heart disease in populations from East and West Finland. Advances in Cardiology, 18: 196–207.

    Google Scholar 

  47. K. Ball and R. Turner, 1974, Smoking and the heart. The basis for action. Lancet, ii: 822–826.

    Article  Google Scholar 

  48. W. B. Kannel and T. R. Dawber, 1974, Hypertension as an ingredient of cardiovascular risk profile. Br. J. Hosp. Med., 11: 508–23.

    Google Scholar 

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© 1989 Plenum Press, New York

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Darlington, L.G., Scott, J.T. (1989). Can Risk Scores for Vascular Disease in Gout Patients be Improved?. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_32

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  • DOI: https://doi.org/10.1007/978-1-4684-5673-8_32

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