Guanine Nucleotide Metabolism in Red Blood Cells: The Metabolic Basis for GTP Depletion in HGPRT and PNP Deficiency
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The salvage cycles of purine bases include the activity of 5′-nucleotidase on IMP and GMP to form the respective nucleosides inosine (Ino) and guanosine (Guo); further degradation of the nucleosides by purine nucleoside phosphorylase (PNP) to Hx and Gu, and the ribophosphorylation of these bases by HGPRT to IMP and GMP, respectively.
KeywordsMetabolic Basis Mycophenolic Acid Purine Nucleotide Purine Base Purine Nucleoside Phosphorylase
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