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The Effects of Temperature and Buffer Concentration on the Metabolism of Human Atrial Appendages Measured by 31P and 1H NMR

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Oxygen Transport to Tissue XI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 248))

Abstract

Animal hearts are commonly used as models for human tissue in studies defining conditions for the preservation of heart tissue destined for transplantion. Human atrial appendages, removed during open heart surgery, have been used on occasion to determine the optimum temperature for the preservation of grafts prior to transplant [1,2]. We use 31P and 1H nuclear magnetic resonance (NMR) to follow the time course of metabolite levels in human atrial appendages to gain a better understanding of tissue energetics under various preservation conditions.

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References

  1. R. Deslauriers, W. J. Keon, S. Lareau, D. Moir, J. K. Saunders, I. C. P. Smith, K. Whithehead & G. W. Mainwood, Cardiac hypothermia: 31P & 1H NMR studies of human myocardial tissue, J. Thorac. & Cardiovasc. Surg., In Press.

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Author information

Authors and Affiliations

  1. Department of Physiology, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada

    Graham W. Mainwood

  2. Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada

    Sylvain Lareau, Kristine Whitehead & Roxanne Deslauriers

  3. Department of Cardiothoracic Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, K1Y 4E9, Canada

    Wilbert J. Keon

Authors
  1. Graham W. Mainwood
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  2. Sylvain Lareau
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  3. Kristine Whitehead
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  4. Wilbert J. Keon
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  5. Roxanne Deslauriers
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Editor information

Editors and Affiliations

  1. University of Ottawa, Ottawa, Ontario, Canada

    Karel Rakusan  & George P. Biro  & 

  2. Northwestern University, Evanston, Illinois, USA

    Thomas K. Goldstick

  3. University of Nijmegen, Nijmegen, The Netherlands

    Zdenek Turek

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© 1989 Plenum Press, New York

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Mainwood, G.W., Lareau, S., Whitehead, K., Keon, W.J., Deslauriers, R. (1989). The Effects of Temperature and Buffer Concentration on the Metabolism of Human Atrial Appendages Measured by 31P and 1H NMR. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_68

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  • DOI: https://doi.org/10.1007/978-1-4684-5643-1_68

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5645-5

  • Online ISBN: 978-1-4684-5643-1

  • eBook Packages: Springer Book Archive

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