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Oxygen Transport to Tissue XI pp 591–599Cite as

Precapillary O2 Loss and Arteriovenous O2 Diffusion Shunt are Below Limit of Detection in Myocardium

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 248))

Abstract

Is venous PO2 an index of tissue PO2, of end capillary PO2, or neither of these because of diffusive shunting from arterioles to venules? To evaluate diffusive shunting and venous PO2 in myocardium we determined hemoglobin (Hb) saturation in arterioles and venules and myoglobin (Mb) saturation in individual subepicardial myocytes by use of a cryomicrospectrophotometric method (Gayeski, 1981, Degner and Gayeski, 1987).

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References

  • Bassingthwaighte, J. B., Yipintsoi, T., and Harvey, R. B., 1974, Microvasculature of the dog left ventricle myocardium, Microvasc. Res., 7:229.

    Article  PubMed  CAS  Google Scholar 

  • Bassingthwaighte, J. B., Yipintsoi, T., and Knoop, T. J., 1984, Diffusional arteriovenous shunting in the heart, Microvasc. Res., 28:233.

    Article  PubMed  CAS  Google Scholar 

  • Clark, A., Clark, P. A. A., Connett, R. J., Gayeski, T. E. J., and Honig, C. R., How large is the drop in PO2 between cytosol and mitochondrial? Am. J. Physiol., 252:C583, 1987.

    PubMed  Google Scholar 

  • Coburn, R. F., Ploegmakers, F., and Gondrii, P., and R. Abboud., 1973, Myocardial myoglobin O2 tension, Am. J. Physiol., 224:870.

    PubMed  CAS  Google Scholar 

  • Degner, F., and Gayeski, T. E. J., 1987, A comparison of a four wavelength analysis and multicomponent wavelength analysis applied to determination of hemoglobin saturation, Adv. Exper. Med. Biol., 215:153.

    CAS  Google Scholar 

  • Duling, B. R., and Berne, R. M., 1970, Longitudinal gradients in periarteriolar oxygen tension, Circ. Res., 27:669.

    PubMed  CAS  Google Scholar 

  • Federspiel, W. J., and Popel, A. S., 1986, A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries, Microvasc. Res., 32:164.

    Article  PubMed  CAS  Google Scholar 

  • Feigl, E. O., 1983, Coronary physiology, Physiol. Rev., 63:1.

    PubMed  CAS  Google Scholar 

  • Gayeski, T. E. J., 1981, A Cryogenic Microspectrophotometric Method for Measuring Myoglobin Saturation in Subcellular Volumes; Application to Resting Dog Muscle, (Ph.D. Thesis), Rochester, NY: University of Rochester, Univ. Microfilms, No. DA9224720, Ann Arbor, MI.

    Google Scholar 

  • Gayeski, T. E. J., Federspiel, W. J., and Honig, C. R., 1988, A graphical analysis of the influence of red cell transit time, carrier-free layer thickness, and intracellular PO2 on blood-tissue O2 transport, Adv. Exper. Med. Biol., 222:25.

    CAS  Google Scholar 

  • Gayeski, T. E. J., and Honig, CR., 1986, O2 gradients from sarcolemma to cell interior in a red muscle at maximal VO2, Am. J. Physiol., 251:789.

    Google Scholar 

  • Gayeski, T. E. J., and Honig, C. R., 1988, Intracellular PO2 in individual cardiac myocytes in dog, cat, rabbit, ferret and rat, Am. J. Physiol., in press.

    Google Scholar 

  • Gayeski, T.E.J., and Honig, CR., 1988, Intracellular PO2 in long axis of individual fibers in working dog gracilis muscle, Am. J. Physiol., 254:H1179.

    PubMed  CAS  Google Scholar 

  • Grayson, J., Davidson, J. W., Fitzgerald-Finch, A., and Scott, C., 1974, The functional morphology of the coronary microcirculation in the dog, Microvasc. Res., 8:20.

    Article  PubMed  CAS  Google Scholar 

  • Groebe, K., and Thews, G., 1986, Theoretical analysis of oxygen supply to contracted skeletal muscle, Adv. Exper. Med. Biol., 200:495.

    CAS  Google Scholar 

  • Harris, P. D., 1986, Movement of oxygen in skeletal muscle., News Phvsiol. Sci., 1:147.

    Google Scholar 

  • Honig, C. R., and Gayeski, T. E. J., 1987, Comparison of intracellular PO2 and conditions for blood-tissue O2 transport in heart and working red skeletal muscle, Adv. Exper. Med. Biol., 215:309.

    CAS  Google Scholar 

  • Huhmann, W., and Niesel, W., 1967, Untersuchungen über die Bedingungen für die Sauerstoffversorgung des Myocards an perfundierten rattenherzen. I. Zür frage nach dem vorliegen einer Gegenstromversorgung. Pflüger’s Arch., 294:250.

    Article  CAS  Google Scholar 

  • Kuo, L. and, Pittman, R. N., 1988, Effect of hemodilution on oxygen transport in arteriolar networks of hamster striated muscle, Am. J. Phvsiol., 254:H331.

    CAS  Google Scholar 

  • Piiper, J., Meyer, M., and Scheid, P., 1984, Dual role of diffusion in tissue gas exchange: blood-tissue equilibration and diffusion shunt, Resp. Physiol., 56:131.

    Article  CAS  Google Scholar 

  • Pittman, R. N., and Duling, B. R., 1977, The determination of oxygen availability in the microcirculation, in: “Oxygen and Physiological Function.” F.F. Jöbsis, ed., Prof. Infor. Library, Dallas, Texas.

    Google Scholar 

  • Rose, C. P., and Goresky, C. A., 1985, Limitations of tracer oxygen uptake in the canine circulation, Circ. Res., 56:57.

    PubMed  CAS  Google Scholar 

  • Rose, C. P., Goresky, C. A., Bach, G. G. Bassingthwaighte, J. B., and Little, S., 1988, In vivo comparison of non-gaseous metabolite and oxygen transport in the heart, Adv. Exp. Med. Biol., 222:45.

    PubMed  CAS  Google Scholar 

  • Roth, A. C., and Feigl, E. O., 1981, Diffusional shunting in the canine myocardium, Circ. Res., 48:470.

    PubMed  CAS  Google Scholar 

  • Roth, A. C., and Wade, K., 1986, The effects of transmural transport in the microcirculation: A two gas species model, Microvasc. Res., 32:64.

    Article  PubMed  CAS  Google Scholar 

  • Schubert, R. W., Whalen, W. J., and Nair, P., 1978, Myocardial PO2 distribution: Relationship to coronary autoregulation, Am. J. Phvsiol., 234:H361.

    CAS  Google Scholar 

  • Weiss, H. R., Neubauer, J. A., Lipp, J. A., and Sinha, A. K., 1978, Quantitative determination of regional oxygen consumption in the dog heart, Circ. Res., 42:394.

    PubMed  CAS  Google Scholar 

  • Weiss, H. R., and Sinha, A. K., 1978, Regional oxygen saturation of small arteries and veins in the canine myocardium, Circ. Res., 42:119.

    PubMed  CAS  Google Scholar 

  • Whalen, W. J., Nair, P., and Buerk, D., 1973, O2 tension in the beating cat heart in situ, in: “O2 Supply.” M. Kessler, D. F. Bruley, L. C. Clark, Jr., D. W. Lübbers, I. K. Silver, and J. Strauss, eds., University Park Press, Baltimore, Maryland.

    Google Scholar 

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Author information

Authors and Affiliations

  1. The University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY, 14642, USA

    C. R. Honig & T. E. J. Gayeski

Authors
  1. C. R. Honig
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  2. T. E. J. Gayeski
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Editor information

Editors and Affiliations

  1. University of Ottawa, Ottawa, Ontario, Canada

    Karel Rakusan  & George P. Biro  & 

  2. Northwestern University, Evanston, Illinois, USA

    Thomas K. Goldstick

  3. University of Nijmegen, Nijmegen, The Netherlands

    Zdenek Turek

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© 1989 Plenum Press, New York

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Honig, C.R., Gayeski, T.E.J. (1989). Precapillary O2 Loss and Arteriovenous O2 Diffusion Shunt are Below Limit of Detection in Myocardium. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_66

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  • DOI: https://doi.org/10.1007/978-1-4684-5643-1_66

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5645-5

  • Online ISBN: 978-1-4684-5643-1

  • eBook Packages: Springer Book Archive

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