Abstract
During the last decade the important role of endothelium in the local control of vascular smooth muscle function has become more and more evident. In response to various chemical and physical stimuli, vascular endothelial cells synthesize and release substances which can induce changes in tone of the underlying smooth muscle cells (1,5,17,20,24,25,27). In addition, due to the uptake and the enzymatic conversion or breakdown of several circulating vasoactive substances, endothelium influences their activity in vascular smooth muscle (s. 25). Oxygen metabolites are able to influence or even disrupt these functions. Various reactive intermediates of oxygen metabolism cause characteristic changes in the metabolism of the vascular endothelial cells and induce e.g. an increased production of certain arachidonic acid metabolites (4,11,19,25). In vitro experiments suggest that oxidizing free radicals facilitate the release of the endo-thelium-derived relaxing factor(s) (EDRF) and a smooth muscle relaxation while superoxide anions depress the EDRF mediated decrease in smooth muscle tone (s. 25). Following exposure to a variety of free radicals, endothelial cell lesions, most frequently in the area of intercellular junctions, and also cytolysis were observed (11-13).
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© 1989 Plenum Press, New York
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Grote, J., Siegel, G., Zimmer, K., Adler, A. (1989). The Interaction Between Oxygen and Vascular Wall. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_64
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DOI: https://doi.org/10.1007/978-1-4684-5643-1_64
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