Skip to main content
SpringerLink
Log in

The Influence of Different Anesthetics on the Oxygen Delivery to and Consumption of the Heart

  • Chapter
Oxygen Transport to Tissue XI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 248))

Abstract

It is well known that some routinely used anesthetics, e.g. halothane, have a severely depressive effect on the cardiovascular system (1,2,3). These depressive effects include: decreased myocardial contractility, decreased systolic as well as diastolic blood pressure as well as a decreased cardiac output. Studies in cell cultures demonstrate, that halothane reduces oxygen consumption and contraction rate of the heart myocyt (4) and affects the uptake and availability of Ca2+ (5,6).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sontagg H, Merin RG, Donath H, Radke J, Schenk HD. (1976) Myocardial function and metabolism in the conscious dog and during halothane anesthesia. Anesthesiology.: 51: 204–210.

    Article  Google Scholar 

  2. Merin RG, Kumazawa T, Luka HL. (1979) Myocardial metabolism and oxygenation in man awake and during halothane anesthesia. Anesthesiology.: 44: 402–415.

    Article  Google Scholar 

  3. Merin RG, Verdouw PD, De Jong JW. (1977) Dose-dependent depression of cardiac function and metabolism by halothane in swine (Sus scrofa). Anesthesiology 46: 417–423.

    Article  PubMed  CAS  Google Scholar 

  4. Albrecht RF, Miletich DJ, Dinsmore P. (1985). Comparative metabolic effects of halothane and enflurane in rat heart cell culture. J. Cardiovasc. Pharmacol: 7: 799–804.

    Article  PubMed  CAS  Google Scholar 

  5. Komai H, Rusy BF. (1987). Negative inotropic effects of isoflurane and halothane in rabbit papillary muscles. Anesth. Analg.: 66: 29–33.

    Article  PubMed  CAS  Google Scholar 

  6. Malinconico SM, Hartzeil CR, McCarl RL. (1983). Effect of calcium on halothane-depressed beating in heart cells in culture. Mol. Pharmacol.: 23: 417–423.

    PubMed  CAS  Google Scholar 

  7. Saxena PR, Verdouw PD (1985). 5-Carboxamidetryptamine, a compound with high affinity for 5-hydroxytryptamine binding sites, dilates arterioles and constricts arteriovenous anastomoses. Br. J. Pharmac: 84: 533–544.

    CAS  Google Scholar 

  8. Saxena PR, Schamhardt HC, Forsyth RP, Loeve J. (1980). Computer programs for the radioactive microsphere technique. Determination of regional blood flows and other haemodynamic variables in different experimental circumstances. Comp. Prog. Biomed.: 12: 63–84.

    Article  CAS  Google Scholar 

  9. Saxena PR. (1985). An interactive computer programme for data management and parametric and non-parametric statistical analysis. Proc. Br. Pharmacol. Soc: Edinburg: p. D3.

    Google Scholar 

  10. Malincino SM, Hartzell CR, McCarl RL. (1983). Effect of calcium on halothane-depressed beating in heart cells in culture. Mol. Pharmacol.: 23: 417–423.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Erasmus University, Postbus 1738, 3000 DR, Rotterdam, The Netherlands

    G. J. van Daal, B. Lachmann, W. Schairer, R. Tenbrinck & W. Erdmann

  2. Depts. of Anesthesiology and Experimental Cardiology, Thorax centre, Postbus 1738, 3000 DR, Rotterdam, The Netherlands

    L. J. van Woerkens & P. Verdouw

Authors
  1. G. J. van Daal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Lachmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Schairer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Tenbrinck
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. J. van Woerkens
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Verdouw
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. W. Erdmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Ottawa, Ottawa, Ontario, Canada

    Karel Rakusan  & George P. Biro  & 

  2. Northwestern University, Evanston, Illinois, USA

    Thomas K. Goldstick

  3. University of Nijmegen, Nijmegen, The Netherlands

    Zdenek Turek

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

van Daal, G.J. et al. (1989). The Influence of Different Anesthetics on the Oxygen Delivery to and Consumption of the Heart. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_58

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5643-1_58

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5645-5

  • Online ISBN: 978-1-4684-5643-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation