Abstract
The isolated, Langendorff-perfused rat heart is used extensively in biomedical investigation. This preparation is generally perfused with aqueous buffers oxygenated with high-oxygen gas mixtures. In spite of high pO2, because of the poor solubility of oxygen in water, the oxygen content of such perfusates is quite low: generally not exceeding 1.5 ml/dl. Adequate oxygen delivery to the the myocytes can only be maintained under these conditions by nearly maximal coronary vasodilation.
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© 1989 Plenum Press, New York
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Biro, G.P., Masika, M., Korecky, B. (1989). Oxygen Delivery and Performance in the Isolated, Perfused Rat Heart: Comparison of Perfusion with Aqueous and Perfluorocarbon-Containing Media. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_56
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DOI: https://doi.org/10.1007/978-1-4684-5643-1_56
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