Hyperoxic Intubation Apnoea: An In Vivo Model for the Proof of the Christiansen-Douglas-Haldane Effect

  • Fritz Mertzlufft
  • Ludwig Brandt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)


The Christiansen-Douglas-Haldane effect (HALDANE effect) describes the different CO2 binding capacity of haemoglobin on its degree of oxygenation and was first demonstrated in vitro in 1914 (Christiansen, Douglas and Haldane, 1914).


Venous Shunting Mixed Venous Blood High pC02 HALDANE Effect Arterial Carbon Dioxide Partial Pressure 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Fritz Mertzlufft
    • 1
  • Ludwig Brandt
    • 1
  1. 1.Klinik für Anaesthesiologie, Johannes Gutenberg-UniversitätMainzGermany

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