Abstract
Oxygen-carrying plasma substitutes based on emulsified perfluorocarbons (PFCs) have undergone extensive experimental and clinical evaluation over the last 10 years. Though they were originally introduced as “artificial blood”, it is clear that their use will probably be largely in more specialised areas such as improvement of microcirculatory oxygenation in, for instance, the treatment of myocardial and cerebral ischaemia (Böse et al. 1986; Faithfull et al. 1986) or improvement of oxygenation, and hence radiosensitivity, of malignant tumours (Teicher and Rose 1984).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bose, B., Osterholra, J.L., Payne, J.B. and Chambers, K., 1986. Preservation of neuronal function during prolonged focal cerebral ischemia by ventriculocisternal perfusion with oxygenated fluorocarbon emulsion. Neurosurgery 18:270.
Colman, R.W., Chang, L.K., Mukherji, B. and Sloviter, H.A., 1980. Effects of a perfluoro erythrocyte substitute on platelets in vitro and in vivo. J. Lab. Clin. Med. 95:553.
Clark, L.C., Kaplan, S. and Becattini, F., 1970. The physiology of synthetic blood. J. Thorac. Cardiovasc. Surg. 60: 757.
Erdmann, W., 1982. 02 Diffusion coefficients. In:Oxygen Carrying Colloidal Blood Substitutes, Eds. Frey R, Beisbarth H, Stossek K. W Zuckschwerdt Verlag, Munich. p 143.
Faithfull, N.S., Fennema, M., Erdmann, W., Lapin, R., Smith, A.R., van Alphen, W., Essed, C.E. and Trouwborst, A., 1985. Tissue oxygenation by fluorocarbons. Adv. Exp. Med. Biol. 180:569.
Faithfull, N.S., Erdmann, W., Fennema, M. and Kok, A., 1986. The effects of haemodilution with fluorocarbons or dextran on oxygen tensions in the acutely ischaemic myocardium. Brit. J. Anaesth. 58:1031.
Faithfull, N.S., King, C.E. and Cain, S.M., 1987. Peripheral vascular responses to fluorocarbon administration. Microvasc. Res. 33:183.
Faithfull, N.S. and Cain, S.M., 1988. Critical oxygen delivery following haemodilution with dextran or Fluosol-DA. J. Crit. Care 3:14.
Faithfull, N.S. and Cain, S.M., 1988. Cardiorespiratory consequences of fluorocarbon rections in dogs. Biomat. Art. Cells and Art. Organs 16:463.
Moll, W., 1973. Placental Function and oxygenation in the foetus. Adv. Exp. Med. Biol. 37:1017.
Naito, R., Fujita, Y. and Suyama, T., 1978. Studies on teratogenicity of Fluosol-DA in rats. In: Proceedings of the Symposiun on Research on Perfluorochemicals in Medicine and Biology. V. Novakova and L.-O. Plantin, eds. GOTAB, Stockholm.
O’Brodovich, H., Belbeck, L., Andrew, M. and Coates, G., 1985. Fluosol-DA causes pulmonary hypertension and increased lymph lung flow in un anesthetised sheep. Clin. Invest. Med. 8:15.
Rude, R.E., Bush, L.R. and Tilton, G.D., 1984. Effects of fluorocarbons with and without oxygen supplementation on cardiac hemodynamics and Energetics. Am. J. Cardiol. 54:80.
Saeed, M., Hartmann, A. and Bing, R., 1987. Inhibition of vasoactive agents by perfluorochemical emulsion. Life Sci. 40:1971.
Shakir, K.M.M., and Williams, T.J., 1982. Inhibition of Phospholipase A2 acticity by Fluosol, and artificial blood substitute. Prostoglandins 23:919.
Teicher, B.A. and Rose, C. M, 1984. Oxygen-carrying perfluorochemical emulsion as an adjuvent to radiation therapy in mice. Cancer Res. 44:4285.
Tremper, K.K., Vercellotti, G.M. and Hammerschmidt, D.E., 1984. Hemodynamic profile of adverse clinical reactions to Fluosol-DA 20%. Crit. Care Med. 12:428.
Vercellotti, G.M., Hammerschmidt, D.E., Craddock, P.R., and Jacob, H.S., 1982. Activation of plasma complement by perfluorocarbon artificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroid prophylaxis. Blood 59:1299.
Vileisis, R.A., 1985. Effect of Maternal Oxygen Inhalation on the fetus with growth retardation. Ped. Res. 19:324.
Wigglesworth, J.S., 1964. Experimental growth retardation in the foetal rat. Pathol. Bacteriol. 88:1.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Faithfull, N.S., Marshall, H.W. (1989). The Effect of Fluorocarbon Emulsion on Placental Insufficiency. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_39
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5643-1_39
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5645-5
Online ISBN: 978-1-4684-5643-1
eBook Packages: Springer Book Archive