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The Nature of Fluorocarbon Enhanced Cerebral Oxygen Transport

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Oxygen Transport to Tissue XI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 248))

Abstract

This brief communication is intended to epitomize our on-going research relating blood and brain fluorocarbon levels to Polarographic oxygen availability (aO2) as recorded from healed platinum electrodes in the brain of conscious rabbits. The current from such cathodes becomes stable in about ten days and remains steady for months, or even years, with mean currents of about 600 nanoamperes (nA) and oscillations at 10 per minute with an amplitude of up to 300nA. When oxygen is administered the aO2 current increases to about 900nA. Following the administration of a variety of fluorocarbon emulsions and oxygen breathing the aO2 current is further increased even though cerebral venous (sagittal sinus) pO2 is not increased. The results presented here, based upon several hundred hours of continuous recording of aO2 currents, were selected to emphasize this apparent paradox.

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Author information

Authors and Affiliations

  1. Division of Neurophysiology, Children’s Hospital Research Foundation, Cincinnati, Ohio, 45229-2899, USA

    Leland C. Clark Jr., Robert B. Spokane & Richard E. Hoffmann

  2. Department of Psychiatry, Wright State University School of Medicine, Dayton, Ohio, 45401, USA

    Ranjan Sudan

Authors
  1. Leland C. Clark Jr.
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  2. Robert B. Spokane
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  3. Richard E. Hoffmann
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  4. Ranjan Sudan
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Editor information

Editors and Affiliations

  1. University of Ottawa, Ottawa, Ontario, Canada

    Karel Rakusan  & George P. Biro  & 

  2. Northwestern University, Evanston, Illinois, USA

    Thomas K. Goldstick

  3. University of Nijmegen, Nijmegen, The Netherlands

    Zdenek Turek

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© 1989 Plenum Press, New York

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Clark, L.C., Spokane, R.B., Hoffmann, R.E., Sudan, R. (1989). The Nature of Fluorocarbon Enhanced Cerebral Oxygen Transport. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_38

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  • DOI: https://doi.org/10.1007/978-1-4684-5643-1_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5645-5

  • Online ISBN: 978-1-4684-5643-1

  • eBook Packages: Springer Book Archive

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