Skip to main content

Low Viscosity of Densely and Highly Polymerized Human Hemoglobin in Aqueous Solution — the Problem Of Stability

  • Chapter
Oxygen Transport to Tissue XI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 248))

Abstract

In case of chronic and acute tissue oxygen deficit it is of advantage to have an artificial oxygen carrying blood substitute in order to support a least temporarily blood function. From a physico-chemical point of view an artificial oxygen carrying blood substitute must meet 4 main requirements at the desired concentration.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. W.K.R. Barnikol and O. Burkhard, Highly Polymerized Human Haemoglobin for Oxygen Carrying Blood Substitue, Advances in Biology and Medicine 215:129 (1987).

    CAS  Google Scholar 

  2. W.K.R. Barnikol and O. Burkhard, Huge Compact Soluble Molecules: A New Old Concept to Develop an Oxygen Carrying Blood Substitute, J. Biomaterial, Artificial Cells and Artificial Organs, 1988, in press.

    Google Scholar 

  3. W.K.R. Barnikol and H. Pötzschke, Ein stabiles Polymere aus menschlichem Hämoglobin mit niedrigem kolloidosmoti-schem Druck als Kandidat eines Sauerstofftransportierenden Blutersatzes, Hoppe-Seylers Physiologische Chemie 369: 793 (1988).

    Google Scholar 

  4. F. De Venuto and A. Zegna, Blood exchange with pyridoxola-ted and polymerized human hemoglobin solution, Surg., Gynecol., Obstetrics 155:342 (1982).

    Google Scholar 

  5. W.K.R. Barnikol and O. Burkhard, Verfahren zur Polymerisation von Hämoglobin mittels verknüpfenden Reagenzien, European Patent 85106057.4 (1985).

    Google Scholar 

  6. W.K.R. Barnikol and O. Burkhard, Verfahren zur Modifikation, insbesondere zur Polymerisation von Hämoglobin in vitro, German Patent P 3714351.4 (1987).

    Google Scholar 

  7. K. Iwasaki and Y. Iwashita, Preparation and evaluation of hemoglobin-polyethylen glycol conjugate (pyridoxalated Polyethylen glycol hemoglobin) as an oxygen-carrying resuscitation fluid, Artif. Organs 10:411 (1986).

    Article  PubMed  CAS  Google Scholar 

  8. N. Kothe and K. Bonhard, Characterization of a modified stroma-free hemoglobin solution as an oxygen-carrying plasma substitute, Surg., Gynecol., Obstetrics 161:563 (1985).

    CAS  Google Scholar 

  9. A. Einstein, Eine neue Bestimmung der Moleküldimensionen, Ann. Physik 12:289 (1906).

    Article  Google Scholar 

  10. A. Einstein, Berichtigung zu meiner Arbeit: “Eine neue Bestimmung der Moleküldimensionen, Ann. Physik 34:591 (1911).

    Article  CAS  Google Scholar 

  11. Ch. Tanford, Physical Chemistry of macromolecules, John Wiley & Sons, 1967.

    Google Scholar 

  12. E. Antonini and M. Brunori, Hemoglobin and myoglobin in their reactions with ligands, Frontiers of Biology, Vol. 21, North-Holland Publishing Company, Amsterdamm, London, 1971.

    Google Scholar 

  13. E. Gendler, S. Gendler, and M.E. Nimni, Toxic reactions evoked by glutardialdehyde-fixed pericardium and cardiac valve tissue bioprosthesis, J. Biomed. Mater. Res. 18:727 (1984).

    Article  PubMed  CAS  Google Scholar 

  14. M. Feola, J. Simoni, P.C. Canizaro, R. Tran, G. Raschbaum, F.J. Behal, Toxicity of polymerized hemoglobin solutions, Surg., Gynecol, Obstetrics 166:211 (1988).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Barnikol, W.K.R., Burkhard, O. (1989). Low Viscosity of Densely and Highly Polymerized Human Hemoglobin in Aqueous Solution — the Problem Of Stability. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5643-1_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5645-5

  • Online ISBN: 978-1-4684-5643-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics