Skip to main content

Mechano-Electrical Transduction in Turtle Hair Cells

  • Chapter
Cochlear Mechanisms: Structure, Function, and Models

Part of the book series: NATO ASI Series ((NSSA))

Abstract

The initial step in hair cell transduction involves coordinated flexion of an array of microvilli, the hair bundle, which gates a membrane conductance enabling a transducer current to flow into the cell (Hudspeth & Corey, 1977; Ohmori, 1985). Although the ionic selectivity of the transducer conductance is known (Corey & Hudspeth, 1979; Ohmori, 1985), the events leading to activation of the channel are not fully understood, and there is no consensus even on the precise form of relationship between bundle displacement and transducer current. Here we present some observations on the transduction process in turtle hair cells measured both directly in isolated cells under voltage clamp and indirectly from receptor potentials in the intact ear.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Art, J.J. & Fettiplace, R. (1987) Variation of membrane properties in hair cells isolated from the turtle cochlea. J. Physiol. 385, 207–242.

    PubMed  CAS  Google Scholar 

  • Art, J.J., Crawford, A.C. & Fettiplace, R. (1986) Ionic currents in solitary turtle hair cells. In: Auditory frequency selectivity (Eds: Moore, B.C.J. & Patterson, R.D.) Plenum Press, New York, pp. 81–88.

    Google Scholar 

  • Corey, D.P. & Hudspeth, A.J. (1979) Ionic basis of the receptor potential in a vertebrate hair cell. Nature 281, 675–677.

    Article  PubMed  CAS  Google Scholar 

  • Corey, D.P. & Hudspeth, A.J. (1983) Kinetics of the receptor current in bullfrog saccular hair cells. J. Neurosci. 3, 962–976.

    PubMed  CAS  Google Scholar 

  • Crawford, A.C. & Fettiplace, R. (1980) The frequency selectivity of auditory nerve fibres and hair cells in the cochlea of the turtle. J. Physiol. 306, 79–125.

    PubMed  CAS  Google Scholar 

  • Crawford, A.C. & Fettiplace, R. (1981) Non-linearities in the responses of turtle cochlear hair cells. J. Physiol. 315, 317–338.

    PubMed  CAS  Google Scholar 

  • Crawford, A.C. & Fettiplace, R. (1983) Auditory nerve responses to imposed displacements of the turtle basilar membrane. Hearing Res. 12, 199–208.

    Article  CAS  Google Scholar 

  • Crawford, A.C. & Fettiplace, R. (1985) The mechanical properties of ciliary bundles of turtle cochlear hair cells. J. Physiol. 364, 359–379.

    PubMed  CAS  Google Scholar 

  • Crawford, A.C. & Fettiplace, R. (1987) A substage cooling attachment for Zeiss IM microscopes. J. Physiol. 396, 13P.

    Google Scholar 

  • Holton, T. & Hudspeth, A.J. (1986) The transduction channel of hair cells from bull-frog characterized by noise analysis. J. Physiol. 375, 195–227.

    PubMed  CAS  Google Scholar 

  • Hudspeth, A.J. & Corey, D.P. (1977) Sensitivity, polarity and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli. Proc. Nat. Acad. Sci. U.S.A. 74, 2407–2411.

    Article  CAS  Google Scholar 

  • Ohmori, H. (1985) Mechano-electrical transduction currents in isolated vestibular hair cells. J.Physiol. 359, 189–217.

    PubMed  CAS  Google Scholar 

  • Ohmori, H. (1986) Gating properties of the mechano-electrical transducer channel in the dissociated vestibular hair cell of the chick. J. Physiol. 387, 589–609.

    Google Scholar 

  • Russell, I.J., Cody, A.R. & Richardson, G.P. (1986) The responses of inner and outer hair cells in the basal turn of the guinea pig cochlea and in the mouse cochlea grown in vitro. Hearing Res. 22, 199–216.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Fettiplace, R., Crawford, A.C. (1989). Mechano-Electrical Transduction in Turtle Hair Cells. In: Wilson, J.P., Kemp, D.T. (eds) Cochlear Mechanisms: Structure, Function, and Models. NATO ASI Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5640-0_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5640-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5642-4

  • Online ISBN: 978-1-4684-5640-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics