Abstract
The unusual basic amino acid hypusine [Nε-(4-amino-2-hydroxybutyl) lysine] is a derivative of lysine which was originally isolated from a trichloroacetic acid-soluble extract of bovine brain (1). Subsequently it was found that in its free form hypusine concentration is highest in the brain (2), whereas, as a protein component, testes are the richest source (3). Furthermore, in developing rats, the hypusine concentration in brain protein is higher in the first 2 weeks of postnatal life and then steadily decreases until adulthood (3). In this organ the amino acid is also present bound to γ-aminobutyric acid (GABA) (4).
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References
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© 1988 Plenum Press, New York
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Abbruzzese, A., Liguori, V., Park, M.H. (1988). Deoxyhypusine Hydroxylase. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_40
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DOI: https://doi.org/10.1007/978-1-4684-5637-0_40
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