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Estrogenic Control of Spermidine/Spermine N1-Acetyltransferase Activity in Rat Uterus

  • Chapter
Progress in Polyamine Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 250))

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Abstract

It is widely accepted that specific intracellular receptor proteins are implicated in the estrogen regulation of gene expression, growth and differentiation in target cells. The unoccupied forms of these receptors, as suggested by Jensen and Jacobson1 and Gorski et al.,2 reside primarily in the cytoplasm and translocate to the nucleus after hormone interaction. A revision of this classical “two-step” model has recently indicated that both native and ligand-bound forms of the receptors are localized in the nucleus, as supported by biochemical3 and immunocytochemical4 data. The binding of estrogen with receptor leads to a change in the conformational state of the protein, which increases its affinity for nuclear components and DNA.3, 4 A number of nuclear acceptor sites have been proposed, including specific DNA sequences,5 ribonucleoprotein,6 basic nonhistone proteins, nuclear matrix,8 and acidic nonhistone protein DNA complexes.9 The binding of activated receptor with DNA or other nuclear components triggers the synthesis of specific proteins, growth, and differentiation in responsive tissues.

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Authors and Affiliations

  1. Institute of General Pathology and Center for Research on Cell Pathology , C.N.R., Via Mangialli 31, 20133, Milan, Italy

    Antonio Perin, Angela Sessa & M. Alfonsina Desiderio

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  1. Antonio Perin
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  2. Angela Sessa
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  3. M. Alfonsina Desiderio
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Editors and Affiliations

  1. Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

    Vincenzo Zappia

  2. The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

    Anthony E. Pegg

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© 1988 Plenum Press, New York

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Perin, A., Sessa, A., Desiderio, M.A. (1988). Estrogenic Control of Spermidine/Spermine N1-Acetyltransferase Activity in Rat Uterus. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_30

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  • DOI: https://doi.org/10.1007/978-1-4684-5637-0_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5639-4

  • Online ISBN: 978-1-4684-5637-0

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