Abstract
Ornithine decarboxylase (ODC, EC 4.1.1.17) which decarboxylates ornithine to form putrescine, is the key enzyme in mammalian polyamine biosynthesis. ODC is characterized by its inducibility and rapid turnover rate (half lifeā¼15 min). ODC activity in quiescent cells is extremely low and is increased within a few hours in response to many different stimuli, including hormones, growth factors, and tumor promoters. In general the induction of ODC activity and subsequent accumulation of putrescine constitute a part of a cascade of biochemical events that accompany cell proliferation and differentiation (1, 2).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A.E. Pegg, Recent advances in the biochemistry of polyamines in eukaryotes, Biochem. J. 234: 249 (1986).
A.E. Pegg, Polyamine Metabolism and Its Importance in Neoplastic Growth and as a Target for Chemotherapy, Cancer Res. 48: 759 (1988).
T.G. OāBrien, R.C. Simsiman, and R.K. Boutwell, Induction of polyamine-biosynthetic enzymes in mouse epidermis by tumor promoting agents, Cancer Res. 35: 1662 (1975).
A.K. Verma and R.K. Boutwell, Inhibition of carcinogenesis by inhibitors of putrescine biosynthesis, in: Inhibition of Polyamine Metabolism: āBiological Significance and Basis of New Therapiesā, McCann, P.P., Pegg, A.E., Sjoerdsma, A. eds., pp 249, Academic Press, Inc., Orlando, Florida (1987).
A.K. Verma, D. Erickson, and B.J. Dolnick, Increased mouse epidermal ornithine decarboxylase activity by the tumour promoter 12-0-tetradecanoylphorbol-13-acetate involves increased amounts of both enzyme protein and messenger RNA, Biochem. J. 237: 297 (1986).
S.K. Gilmour, A.K. Verma, T. Madara, and T.G. OāBrien, Regulation of ornithine decarboxylase gene expression in mouse epidermis and epidermal tumors during two-stage tumorigenesis, Cancer Res. 47: 1221 (1987).
A.K. Verma, Inhibition of tumor promoter 12-0-tetradecanoylphorbol-13-acetate-induced synthesis of mouse epidermal ornithine decarboxylase messenger RNA and diacylglycerol-promoted mouse skin tumor formation by retinoic acid, Cancer Res. 48: 2168 (1988).
A.K. Verma, R.C. Pong, and D. Erickson, Involvement of protein kinase C in ornithine decarboxylase gene expression in primary culture of newborn mouse epidermal cells and in skin tumor promotion by 12-0-tetradecano-ylphorbol-13-acetate, Cancer Res. 46: 6149 (1986).
J.T. Hsieh and A.K. Verma, Involvement of protein kinase C in the transcriptional regulation of ornithine decarboxylase gene expression by 12-0-tetradecanoylphorbol-13-acetate in T24 human bladder carcinoma cells, Arch. Biochem. Biophys. 262: 326 (1988).
A. Katz and C. Kahana, Transcriptional activation of mammalian ornithine decarboxylase during stimulated growth, Mol. Cell. Biol. 7: 2641 (1987).
F.G. Berger, D. Loose, D.H. Meisner, and G. Watson, Androgen induction of messenger RNA in mouse kidney is posttranslational, Biochemistry 25: 1170 (1986).
U. Kikkawa, Y. Takai, Y. Tanaka, R. Miyake, and Y. Nishizuka, Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters, J. Biol. Chem. 258: 11442 (1983).
J.E. Neidel, L.J. Kuhn, and G.R. Vandenbark, Phorbol diester receptor copurifies with protein kinase C, Proc. Natl. Acad. Sci. USA 80: 36 (1983).
C.L. Ashendel, J.M. Staller, and R.K. Boutwell, Solubilization, purification, and reconstitution of a phorbol ester receptor from the particulate protein fraction of mouse brain, Cancer Res. 43: 4327 (1983).
M. Castagna, Y. Takai, K. Kaibuchi, K. Sano, U. Kikkawa, and Y. Nishizuki, Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters, J. Biol. Chem. 257: 7847 (1982).
K.L. Leach and P.M. Blumberg, Modulation of protein kinase C activity and [3H]phorbol-12, 13-dibutyratebinding by various tumor promoters in mouse brain cytosol, Cancer Res. 45: 1958 (1985).
Y. Nishizuka, The role of protein kinase C in cell surface signal transduction and tumor promotion, Nature (Lond.) 308: 693 (1984).
Y. Nishizuka, Prospectives on the role of protein kinase C in stimulus-response coupling, J. Natl. Cancer Inst. 76: 363 (1986).
T. Nakadate, S. Yamamoto, E. Aizu, and R. Kato, Inhibition of 12-0-tetradecanoylphorbol-13-acetate-induced tumor promotion and epidermal ornithine decarboxylase activity in mouse skin by palmitoylcarnitine, Cancer Res. 46: 1589 (1986).
T. Nakadate, S. Yamamoto, M. Ishii, and R. Kato, Inhibition of 12-0-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by phospholipase A2 inhibitors and lipoxygenase inhibition, Cancer Res. 42: 2841 (1982).
R.C. Smart, M.T. Huang, and A.H. Conney, sn-1, 2-Diacylglycerols mimic the effects of 12-0-tetradecano-ylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis, Carcinogenesis (Lond.) 7: 1865 (1986).
A.M. Jetten, B.R. Ganong, G.R. Vandenbark, J.E. Shirley, and R.M. Bell, Role of protein kinase C in diacylglycerolmediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding, Proc. Natl. Acad. Sci. USA 82: 1941 (1985).
A.K. Verma, Protein kinase C activator L-Ī±-dioctanoylglyce-rol: a potent stage II mouse skin tumor promoter, Cancer Res. 48: 1736 (1988).
R.C. Pong, J.T. Hsieh, M.F. Denning, and A.K. Verma, Protein kinase C-mediated phosphorylation of 37 and 40 kD polypeptides and increased transcription of the ornithine decarboxylase gene in the T24 human bladder carcinoma cells, Proc. Am. Assoc. Cancer Res. 29: 77 (1988).
S.K. Gilmour, N. Avdalovic, T. Madara, and T.G. OāBrien, Induction of ornithine decarboxylase by 12-0-tetradecano-ylphorbol-13-acetate in hamster fibroplasts, J.Biol.Chem. 260: 16439 (1985).
J.E. Seely, H. Pƶsƶ, and A.E. Pegg, Effect of androgens on turnover of ornithine decarboxylase in mouse kidney, J.Biol.Chem. 257: 7549 (1982).
D.H. Russell, Posttranslational modification of ornithine decarboxylase by its product putrescine, Biochem. Biophys. Res. Commun. 99: 1167 (1981).
J.S. Heller, W.F. Fong, and E.S. Canellakis, Induction of a protein inhibitor to ornithine decarboxylase by the end product of its reaction, Proc. Natl. Acad. Sci. USA 73: 1858 (1976).
A.K. Verma, C.L. Ashendel, and R.K. Boutwell, Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-0-tetradecanoylphorbol-13-acetate, Cancer Res. 40: 308 (1980).
A.K. Verma and D. Erickson, Induction of mouse epidermal ornithine decarboxylase by the tumor promoter 12-0-tetradecanoylphorbol-13-acetate: dependency on calcium availability, Arch. Biochem. Biophys. 247: 272 (1986).
W.J. Kozumbo, J.L. Seed, and T.W. Kensler, Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate, Cancer Res. 43: 2555 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
Ā© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Verma, A.K., Hsieh, J.T., Pong, R.C. (1988). Mechanisms Involved in Ornithine Decarboxylase Induction by 12-O-Tetradecanoylphorbol-13-Acetate, a Potent Mouse Skin Tumor Promoter and an Activator of Protein Kinase C. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_25
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5637-0_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5639-4
Online ISBN: 978-1-4684-5637-0
eBook Packages: Springer Book Archive