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Human 5′-Deoxy-5′-Methylthioadenosine Phosphorylase: Kinetic Studies and Catalytic Mechanism

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Progress in Polyamine Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 250))

Abstract

5′-Deoxy-5′-methylthioadenosine (MTA), is a sulfur nucleoside ubiquitously distributed in micromolar amounts in nature (1–4). The molecule originates from S-adenosylmethionine (AdoMet) through several metabolic pathways involving in all instances a nucleophilic attack to the activated methylenic γ-carbon adjacent to the electron withdrawing trivalent sulfur (1–10).

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Author information

Authors and Affiliations

  1. Department of Biochemistry of Macromolecules, First Medical School, University of Naples, Via Costantinopoli 16, Naples, Italy

    Vincenzo Zappia, Fulvio Della Ragione, Gabriele Pontoni, Vincenzo Gragnaniello & Maria Cartenì-Farina

Authors
  1. Vincenzo Zappia
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  2. Fulvio Della Ragione
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  3. Gabriele Pontoni
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  4. Vincenzo Gragnaniello
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  5. Maria Cartenì-Farina
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Editor information

Editors and Affiliations

  1. Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

    Vincenzo Zappia

  2. The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

    Anthony E. Pegg

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© 1988 Plenum Press, New York

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Zappia, V., Ragione, F.D., Pontoni, G., Gragnaniello, V., Cartenì-Farina, M. (1988). Human 5′-Deoxy-5′-Methylthioadenosine Phosphorylase: Kinetic Studies and Catalytic Mechanism. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_15

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  • DOI: https://doi.org/10.1007/978-1-4684-5637-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5639-4

  • Online ISBN: 978-1-4684-5637-0

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