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Potential Roles of Polyamine Interconversion in the Mammalian Organism

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Progress in Polyamine Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 250))

Abstract

Presumably many cell types have an enzymatic machinery suitable for the degradation of spermine to spermidine, and of spermidine to putrescine, but systematic studies of polyamine catabolism have not been carried out. In the case of vertebrates it is now firmly established that N1 -acetylation is the first step in this degradative transformation of one polyamine into the other. This reaction may be catalyzed either by the basal or the induced form of acetylCoA: spermidine/spermine N1 -acetyltransferase (cSAT), both of which are cytosolic enzymes (Persson et al., 1985). In the following step the N1-acetylpolyamines are oxidatively cleaved to form spermidine and putrescine, respectively (Seiler, 1981), an oxygen requiring reaction which is catalyzed by the flavine enzyme polyamine oxidase (PAO) (Hölttä, 1977).

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Author information

Authors and Affiliations

  1. Merrell Dow Research Institute, 16, rue d’Ankara, 67084, Strasbourg Cedex, France

    Nikolaus Seiler

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  1. Nikolaus Seiler
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Editors and Affiliations

  1. Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

    Vincenzo Zappia

  2. The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

    Anthony E. Pegg

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© 1988 Plenum Press, New York

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Seiler, N. (1988). Potential Roles of Polyamine Interconversion in the Mammalian Organism. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_13

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  • DOI: https://doi.org/10.1007/978-1-4684-5637-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5639-4

  • Online ISBN: 978-1-4684-5637-0

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