Skip to main content
SpringerLink
Log in

Androgen Regulation of Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase Gene Expression

  • Chapter
Book cover Progress in Polyamine Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 250))

Abstract

The action of androgenic steroids in their target tissues occurs in a receptor-mediated fashion similar to that of other steroid hormones (1–3). Over the last several years, a number of gene products regulated by androgens have been characterized and their induction kinetics in vivo elucidated. The best defined genes fall, with regard to the tissues of their expression, into three main categories: (i) α2u-globulin and the major urinary protein genes are regulated by androgens in rodent liver; (ii) prostatein and seminal vesicle basic protein genes are controlled by androgens in rat accessory sex organs; and (iii) ornithine decarboxylase, β-glucuronidase, RP2, and kidney androgen-regulated protein genes exhibit androgen regulation in murine kidney.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. C. W. Bardin and J. F. Catterall, Testosterone, a major determinant of extragenital sexual dimorphism, Science 211: 1285 (1981).

    Article  PubMed  CAS  Google Scholar 

  2. J. E. Griffin, M. Leishin, and J. D. Wilson, Androgen resistance syndromes, Am. J. Physiol. 243: E81 (1982).

    PubMed  CAS  Google Scholar 

  3. K. K. Kontula, O. A. Jänne, and C. W. Bardin, Intracellular hormone receptor defects and disease, in: “Receptors IV”, P.M. Conn, ed., Academic Press, Orlando, pp. 37–74 (1986).

    Google Scholar 

  4. A. B. Kulkarni, R.M. Gubito, and P. Feigelson, Developmental and hormonal regulation of α2u-globulin gene transcription, Proc. Natl. Acad. Sci. USA 82: 2579 (1985).

    Article  PubMed  CAS  Google Scholar 

  5. N. J. Kuhn, M. Woodworth-Gutai, K. W. Gross, and W. A. Held, Subfamilies of the mouse urinary protein (MUP) multi-gene family: Sequence analysis of cDNA clones and differential regulation in the liver, Nucleic Acids Res. 12: 6073 (1984).

    Article  PubMed  CAS  Google Scholar 

  6. M. G. Parker, R. White, and J. G. Williams, Cloning and characterization of androgen-dependent mRNA from rat ventral prostate, J. Biol. Chem. 255: 6996 (1980).

    PubMed  CAS  Google Scholar 

  7. M. K. Kistler, R. E. Taylor, Jr., J. C. Kandala, and W. S. Kistler, Isolation of recombinant plasmids containing structural gene sequences for rat seminal vesicle secretory proteins IV and V, Biochem. Biophys. Res. Commun. 99: 1161 (1981).

    Article  PubMed  CAS  Google Scholar 

  8. J. F. Catterall, K. K. Kontula, C. S. Watson, P. J. Seppänen, B. Funkenstein, E. Melanitou, N. J. Hickok, C. W. Bardin, and O. A. Jänne, Regulation of gene expression by androgens in murine kidney, Recent Prog. Horm. Res. 42: 71 (1986).

    PubMed  CAS  Google Scholar 

  9. C. S. Watson, D. Salomon, and J. F. Catterall, Structure and expression of androgen-regulated genes in mouse kidney, Ann. N.Y. Acad. Sci. 438: 101 (1984).

    Article  PubMed  CAS  Google Scholar 

  10. K. K. Kontula, T. K. Torkkeli, C. W. Bardin, and O. A. Jänne, Androgen induction of ornithine decarboxylase mRNA in mouse kidney as studied by complementary DNA, Proc. Natl. Acad. Sci. USA 81: 731 (1984).

    Article  PubMed  CAS  Google Scholar 

  11. A. E. Pegg and P. P. McCann, Polyamine metabolism and function, Am. J. Physiol. 243: C212 (1982).

    PubMed  CAS  Google Scholar 

  12. J. E. Seely, H. Pösö, and A. E. Pegg, Purification of ornithine decarboxylase from kidneys of androgen treated mice, Biochemistry 21: 3394 (1982).

    Article  PubMed  CAS  Google Scholar 

  13. V. V. Isomaa, A. E. I. Pajunen, C. W. Bardin, and O. A. Jänne, Ornithine decarboxylase in mouse kidney. Purification, characterization and radioimmunological determination of the enzyme protein, J. Biol. Chem. 258: 6735 (1983).

    PubMed  CAS  Google Scholar 

  14. N. J. Hickok, P. J. Seppänen, G. L. Gunsalus, and O. A. Jänne, Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA, DNA 6: 179 (1987).

    Article  PubMed  CAS  Google Scholar 

  15. M. Gupta and P. Coffino, Mouse ornithine decarboxylase. Complete amino acid sequence deduced from cDNA, J. Biol. Chem. 260: 2941 (1985).

    PubMed  CAS  Google Scholar 

  16. O. A. Jänne, K. K. Kontula, V. V. Isomaa, T. K. Torkkeli, and C. W. Bardin, Androgen-receptor dependent regulation of ornithine decarboxylase gene expression in mouse kidney, in: “Steroid Hormone Receptors: Structure and function”, H. Eriksson and J.-A. Gustafsson, eds., Elsevier Science Publishers BV, Amsterdam, pp. 461–476 (1983).

    Google Scholar 

  17. L. Persson, J. E. Seely, and A. E. Pegg, Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney, Biochemistry 23: 3777 (1984).

    Article  PubMed  CAS  Google Scholar 

  18. A. Pulkka, T. Taskinen, H. Aaltonen, J. Ramberg, and A. E. I. Pajunen, Studies on the degradation of ornithine decarboxylase by the immunoblotting technique, Biochem. Int. 11: 845 (1985).

    PubMed  CAS  Google Scholar 

  19. M. Macrae and P. Coffino, Complementation of a polyamine-deficient Escherichia coli mutant by expression of mouse ornithine decarboxylase, Mol. Cell. Biol. 7: 564 (1987).

    PubMed  CAS  Google Scholar 

  20. J. E. Seely and A. E. Pegg, Changes in mouse kidney ornithine decarboxylase activity are brought about by changes in the amount of enzyme protein as measured by radioimmunoassay, J. Biol. Chem. 258: 2496 (1983).

    PubMed  CAS  Google Scholar 

  21. S. Rogers, R. Wells, and M. Rechsteiner, Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis, Science 234: 364 (1986).

    Article  PubMed  CAS  Google Scholar 

  22. C. Kahana and D. Nathans, Translational regulation of mammalian ornithine decarboxylase by polyamines, J. Biol. Chem. 260: 15390 (1985).

    PubMed  CAS  Google Scholar 

  23. E. Hölttä and P. Pohjanpelto, Control of ornithine decarboxylase in Chinese hamster ovary cells by polyamines. Translational inhibition of synthesis and acceleration of degradation of the enzyme by putrescine, spermidine, and spermine, J. Biol. Chem. 261: 9502 (1986).

    PubMed  Google Scholar 

  24. A. E. I. Pajunen, V. V. Isomaa, O. A. Jänne, and C. W. Bardin, Androgenic regulation of ornithine decarboxylase activity and its relationship to changes in cytosol and nuclear androgen receptors, J. Biol. Chem. 257: 8190 (1982).

    PubMed  CAS  Google Scholar 

  25. G. J. Sertich and A. E. Pegg, Polyamine administration reduces ornithine decarboxylase activity without affecting the mRNA content, Biochenu Biophys. Res. Commun. 143: 424 (1987).

    Article  CAS  Google Scholar 

  26. N. J. Hickok, P. J. Seppänen, K. K. Kontula, P. A. Jänne, C. W. Bardin, and O. A. Jänne, Two ornithine decarboxylase mRNA species in mouse kidney arise from size heterogeneity at their 3′ termini, Proc. Natl. Acad. Sci. USA 83: 594 (1986).

    Article  PubMed  CAS  Google Scholar 

  27. C. Kahana and D. Nathans, Nucleotide sequence of murine ornithine decarboxylase mRNA, Proc. Natl. Acad. Sci. USA 82: 1673 (1985).

    Article  PubMed  CAS  Google Scholar 

  28. A. Katz and C. Kahana, Isolation and characterization of the mouse ornithine decarboxylase gene, J. Biol. Chem. 263: 7604 (1988).

    PubMed  CAS  Google Scholar 

  29. M. Brabant, L. McConlogue, T. van Daalen Wetters, and P. Coffino, Mouse ornithine decarboxylase gene: Cloning, structure, and expression, Proc. Natl. Acad. Sci. USA 85: 2200 (1988).

    Article  PubMed  CAS  Google Scholar 

  30. R. Winqvist, T. P. Mäkelä, P. Seppänen, O. A. Jänne, L. Alhonen-Hongisto, J. Jänne, K.-H. Grzeschik, and K. Alitalo, Human ornithine decarboxylase sequences map to chromosome regions 2pter→p23 and 7cen→qter but are not co-amplified with the NMYC oncogene, Cytogenet. Cell. Genet. 42: 133 (1986).

    Article  PubMed  CAS  Google Scholar 

  31. O. A. Jänne, K. K. Kontula, V. V. Isomaa, and C. W. Bardin, Ornithine decarboxylase mRNA in mouse kidney: A low abundancy gene product regulated by androgens with rapid kinetics, Ann. N.Y. Acad. Sci. 438: 72 (1984).

    Article  PubMed  Google Scholar 

  32. F. G. Berger, D. Loose, H. Meisner, and G. Watson, Androgen induction of messenger RNA concentrations in mouse kidney is posttranscriptional, Biochemistry 25: 1170 (1986).

    Article  PubMed  CAS  Google Scholar 

  33. M. J. Page and M. G. Parker, Effect of androgen on the transcription of rat prostatic binding protein genes, Mol. Cell. Endocrinol. 27: 343 (1982).

    Article  PubMed  CAS  Google Scholar 

  34. E. Melanitou, D. A. Cohn, C. W. Bardin, and O. A. Jänne, Genetic variation in androgen regulation of ornithine decarboxylase gene expression in inbred strains of mice, Mol. Endocrinol. 1: 266 (1987).

    Article  PubMed  CAS  Google Scholar 

  35. A. E. Pegg, D. H. Lockwood, and H. G. Williams-Ashman, Concentrations of putrescine and polyamines and their enzymic synthesis during androgeninduced prostatic growth, Biochem. J. 117: 17 (1970).

    PubMed  CAS  Google Scholar 

  36. K. Käpyaho, A. Kallio, and J. Jänne, Differential effects of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the testosterone-induced growth of ventral prostate and seminal vesicles of castrated rats, Biochem. J. 219: 811 (1984).

    PubMed  Google Scholar 

  37. A. Pajunen, A. Crozat, O. A. Jänne, R. Ihalainen, P. H. Laitinen, B. Stanley, R. Madhubala, and A. E. Pegg, Structure and regulation of mammalian S-adenosylmethionine decarboxylase, J. Biol. Chem., in press (1988).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Population Council, The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA

    Olli A. Jänne, Anne Crozat, Mervi Julkunen, Noreen J. Hickok, Leonard Eisenberg & Evie Melanitou

Authors
  1. Olli A. Jänne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anne Crozat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mervi Julkunen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Noreen J. Hickok
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Leonard Eisenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Evie Melanitou
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

    Vincenzo Zappia

  2. The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

    Anthony E. Pegg

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Jänne, O.A., Crozat, A., Julkunen, M., Hickok, N.J., Eisenberg, L., Melanitou, E. (1988). Androgen Regulation of Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase Gene Expression. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5637-0_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5639-4

  • Online ISBN: 978-1-4684-5637-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation