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Comparative Carcinogenesis : Is There a Theoretical Approach to Inter-Species Similarity ?

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Biologically Based Methods for Cancer Risk Assessment

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Abstract

Comparative carcinogenesis should be understood as the scientific activity dealing with rational analyses and syntheses of the essential differences and similarities between experimental and observed carcinogenesis (‘the mouse-to-man problem’) In this area, two extreme positions can be made out: (1) the ‘optimistic’ one (frequent among regulatory authorities), which accepts a direct “extrapolation” of all kinds of xenobiotic effects from strains of small laboratory animals to the human species, and (2)the ‘pessimistic’ position, which relies upon the argument that no animal data has any value for humans (“man is not a big rat”) .

The paper puts forward the essential mathematical concepts involved and shows some of the fallacies observed in biological applications. By comparing the enunciation of the empirical problem with the suggested dimensional-analytical one,it appears that a scientific solution cannot be envisaged without a deep and novel study of the process of carcinogenesis get rid of current beliefs.

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  1. Institute of Epidemiology and Biometry Department of Mathematical Models, German Cancer Research Centre, D-6900, Heidelberg, INF 280, Germany

    P. Tautu

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  1. Office of Risk Analysis, Oak Ridge National Laboratory, 37831-6109, Oak Ridge, Tennessee, USA

    Curtis C. Travis

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Tautu, P. (1989). Comparative Carcinogenesis : Is There a Theoretical Approach to Inter-Species Similarity ?. In: Travis, C.C. (eds) Biologically Based Methods for Cancer Risk Assessment. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5625-7_8

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  • DOI: https://doi.org/10.1007/978-1-4684-5625-7_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5627-1

  • Online ISBN: 978-1-4684-5625-7

  • eBook Packages: Springer Book Archive

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