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Interspecies Extrapolation

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Biologically Based Methods for Cancer Risk Assessment

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Abstract

One of the fundamental problems in the cancer risk assessment area is the extrapolation of observed experimental results between animal species and man. Lacking detailed information on interspecies differences, it is frequently assumed that experimental results can be extrapolated between species when administered dosage is standardized as either mg/kg body weight per day (body weight scaling) or mg/m2 per day (surface area scaling). Several investigators have argued for the efficacy of one or the other of these procedures (Pinkel, 1958; Freireich et al., 1966; Crouch and Wilson, 1978; Hoel, 1979; Crump and Guess, 1980; Hogan and Hoel, 1982; MRI, 1986; FASEB, 1986; Travis and White, 1988). It is well recognized that neither of these extrapolation procedures will be exactly correct for all compounds and that when species-specific data are available, they should be used in risk assessment. In their absence, body weight or surface area extrapolations are used with the explicit knowledge that they are only approximately correct.

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Authors and Affiliations

  1. Office of Risk Analysis, Oak Ridge National Laboratory, 37831-6109, Oak Ridge, Tennessee, USA

    Curtis C. Travis

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  1. Office of Risk Analysis, Oak Ridge National Laboratory, 37831-6109, Oak Ridge, Tennessee, USA

    Curtis C. Travis

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© 1989 Plenum Press, New York

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Travis, C.C. (1989). Interspecies Extrapolation. In: Travis, C.C. (eds) Biologically Based Methods for Cancer Risk Assessment. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5625-7_7

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  • DOI: https://doi.org/10.1007/978-1-4684-5625-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5627-1

  • Online ISBN: 978-1-4684-5625-7

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