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Kidney Disease in KK Mice: Effect Of Insulin

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Prediabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 246))

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Abstract

We reported that improvement in glucose metabolism with prolonged oral therapy is associated with prevention of glomerulosclerosis and proteinuria in KK mice. However, it is not known whether short-term insulin treatment with improvement in glucose metabolism would similarly prevent the development and progression of glomerulosclerosis in these KK mice. We provide evidence that good glycemic control by early insulin therapy improves both glomerulosclerosis and proteinuria in KK mice.

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References

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Author information

Authors and Affiliations

  1. Department of Medicine, Metropolitan Hospital Research Center, New York Medical College, New York, New York, USA

    R. A. Camerini-Davalos & C. A. Velasco

  2. Department of Medicine, UMDNJ-New Jersey Medical School, Newark, N.J, USA

    A. S. Reddi

  3. Institute of Pathology, University of Freiberg, West Germany

    H. Wehner

Authors
  1. R. A. Camerini-Davalos
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  2. A. S. Reddi
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  3. H. Wehner
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  4. C. A. Velasco
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Editor information

Editors and Affiliations

  1. Diabetes Prevention Research Program, New York Medical College, Metropolitan Hospital Research Center, New York, New York, USA

    Rafael A. Camerini-Davalos

  2. Departments of Community and Preventive Medicine and Pediatrics, New York Medical College, Valhalla, New York, USA

    Harold S. Cole

  3. Bronx Developmental Center, Office of Mental Retardation and Developmental Disabilities of the State of New York, Bronx, New York, USA

    Harold S. Cole

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© 1988 Plenum Press, New York

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Camerini-Davalos, R.A., Reddi, A.S., Wehner, H., Velasco, C.A. (1988). Kidney Disease in KK Mice: Effect Of Insulin. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_41

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  • DOI: https://doi.org/10.1007/978-1-4684-5616-5_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5618-9

  • Online ISBN: 978-1-4684-5616-5

  • eBook Packages: Springer Book Archive

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