Abstract
The hyperglycemia of non-insulin dependent diabetes mellitus (NIDDM) has been attributed to both glucose overproduction by the liver and gluclose under-utilization by peripheral tissues caused by deficient insulin secretion and resistance to insulin action. There is recent evidence that the induction of insulin deficiency creates insulin resistance (1). Several mechanisms have been postulated for the chronic “hypoglycemic” effects of sulfonylurea therapy in NIDDM. In relation to gliclazide (GCZ), there are studies indicating an effect on insulin secretion (2,3,4) and an extra- pancreatic action related to potentiation of the bioeffects of insulin (5,6). In the present study we examined the effects of chronic GCZ therapy on basal insulin levels, glucose and non-glucose (arginine) stimulated insulin responses (Study I), hepatic glucose production rate, peripheral tissue sensitivity to insulin and on red blood cells (RBC) insulin binding (Study II).
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© 1988 Plenum Press, New York
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Wajchenberg, B.J. et al. (1988). Effect of Gliclazide on Non-Insulin Dependent Diabetes Mellitus. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_38
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DOI: https://doi.org/10.1007/978-1-4684-5616-5_38
Publisher Name: Springer, Boston, MA
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