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Kidney Disease in KK Mice: Effect of Glipizide

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Prediabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 246))

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Abstract

We previously demonstrated that glomerulosclerosis and proteinuria can be prevented by control of blood glucose levels either by insulin or glyburide in genetically diabetic KK mice (1,2). Also, we demonstrated that poor control of glucose despite treatment with glyburide did not prevent glomerulosclerosis in a subset of KK mice (2). This reinforces the impact of glycemic control in the prevention of diabetic nephropathy. The purpose of the present study is two-fold: 1) to evaluate the efficacy of another second generation sulfonylurea compound, glipizide, in controlling blood glucose levels in KK mice; and 2) to investigate the relationship between glucose control and structural, biochemical and functional characteristics of kidney disease in KK mice.

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References

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Author information

Authors and Affiliations

  1. Department of Medicine, UMDNJ-New Jersey Medical School, Newark, N.J., USA

    A. S. Reddi & M. Y. Khan

  2. Department of Medicine, Metropolitan Hospital Research Center, New York Medical College, New York, New York, USA

    C. A. Velasco

  3. Department of Pathology, University of Wisconsin Medical School, Madison, Wis., USA

    J. M. B. Bloodworth Jr & R. A. Camerini-Davalos

Authors
  1. A. S. Reddi
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  2. C. A. Velasco
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  3. M. Y. Khan
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  4. J. M. B. Bloodworth Jr
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  5. R. A. Camerini-Davalos
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Editor information

Editors and Affiliations

  1. Diabetes Prevention Research Program, New York Medical College, Metropolitan Hospital Research Center, New York, New York, USA

    Rafael A. Camerini-Davalos

  2. Departments of Community and Preventive Medicine and Pediatrics, New York Medical College, Valhalla, New York, USA

    Harold S. Cole

  3. Bronx Developmental Center, Office of Mental Retardation and Developmental Disabilities of the State of New York, Bronx, New York, USA

    Harold S. Cole

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© 1988 Plenum Press, New York

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Reddi, A.S., Velasco, C.A., Khan, M.Y., Bloodworth, J.M.B., Camerini-Davalos, R.A. (1988). Kidney Disease in KK Mice: Effect of Glipizide. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_37

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  • DOI: https://doi.org/10.1007/978-1-4684-5616-5_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5618-9

  • Online ISBN: 978-1-4684-5616-5

  • eBook Packages: Springer Book Archive

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