Abstract
The presentation of insulin-dependent diabetes (IDDM) in children and young adults usually appears to be sudden (1), suggesting an acute pathology, but we now know that this is only the final step in a process of cumulative beta-cell damage extending over months or even many years. By the time of diagnosis some 80–90% of beta cells have been destroyed. Clinical trials have shown that immunosuppression of newly diagnosed patients may prolong the survival of the remaining beta cells, but it would be log al to intervene at an earlier stage, when the majority of these cells are still viable. This approach could only be considered if it were possible to predict accurately the onset of diabetes in a given individual.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hamilton, D.V., Mundia, S.S., Lister, J., 1976, Mode of presentation of juvenile diabetes. British Medical Journal ii, 211–212.
Barnett, A.H., Eff, C., Leslie, R.D.G., Pyke, D.A., 1981. Diabetes in identical twins. A study of 200 pairs. Diabetologia 20: 97–93.
Nerup, J., Platz, P., Andersen, O.O. et al, 1974, HLA antigens and diabetes mellitus. Lancet i: 864–866.
Walker, A., Cudworth, A.G., 1980, Type 1 (insulin-dependent) diabetic multiplex families: mode of genetic transmission. Diabetes 29: 1036–1039.
Lendrum, R., Walker, G.J., Gamble, D.R., 1975, Islet cell antibodies in juvenile diabetes mellitus. Lancet i: 880–882.
Gamble, D.R., 1980, The epidemiology of insulin dependent diabetes mellitus with particular reference to the relationship of virus infections to its etiology. Epidemiologic Reviews 2: 49–70.
Tillil H., Kobberling, J., 1987, AGe-corrected empirical genetic risk estimates for first degree relatives of IDDM patients. Diabetes 36: 93–99.
Wolf, E., Spencer, K.M., Cudworth, A.G., 1983, The genetic susceptibility to Type I (insulin-dependent) diabetes - analysis of the HLA-DR Association. Diabetologia, 1983, 24: 224–230.
Gorsuch, A.N., Spencer, K.M., Lister, J., Wolf, E., Bottazzo, G.F., Cudworth, A.G., 1982, Can future Type I diabetes be predicted? A study in families of affected children. Diabetes 31: 862–866.
Ginsberg-Fellner, F., Witt, M.E., Bonita, H.F., et al., 1985, Triad of markers for identifying children at high risk of developing insulin- dependent diabetes mellitus. Journal fo the American Medical Association 254: 1469–1472.
Cavender, D., Wagener, D.K., Rabin, B.S. et al., 1984, The Pittsburgh insulin-dependent diabetes mellitus study. HLA antigens and haplo- types as risk factors for the development of IDDM in patients and sibling. Journal of Chronic Disease 37: 555–568.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Gale, E.A.M., Bingley, P.J., Tarn, A.C. (1988). Family Studies of Insulin-Dependent Diabetes: The UK Experience. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5616-5_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5618-9
Online ISBN: 978-1-4684-5616-5
eBook Packages: Springer Book Archive