Skip to main content

Hereditary Diabetes in the KK Mouse: An Overview

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 246))

Abstract

Diabetes and its complications cause increased morbidity and mortality in man. Despite numerous studies, the pathogenesis of these complications is poorly understood. This is partly due to the lack of large and well-controlled human studies. To this end, researchers have been forced to develop animal models of human diabetes. In such animals, the maintenance of controlled environmental conditions and selective breeding over several generations with a large number of offspring can easily be accomplished. This allows for extensive investigation in a relatively short period of time.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kondo, K., Nozawa, K., Tomita, T., and Ezaki, K., 1957, Inbred strains resulting from Japanese mice. Bull Exp Anim 6: 107–12.

    Google Scholar 

  2. Nakamura, M., 1962, A diabetic strain of the mouse. Proc Jap Acad 38: 348–52.

    Google Scholar 

  3. Camerini-Davalos, R.A., Oppermann, W., Mittl, R., and Ehrenreich, T., 1970, Studies of vascular and other lesions in KK mice. Diabetologia 6: 324–329.

    Article  PubMed  CAS  Google Scholar 

  4. Iwatsuka, H., Matsuo, T., Shino, A., and Suzuoki, Z., 1970, Metabolic disturbance of KK mice in chemical diabetes. J Takeda Res Lab 29: 685–692.

    CAS  Google Scholar 

  5. Reddi, A.S., Oppermann, W., Velasco, C.A., Strugatz, L.H. and Camerini-Davalos, R.A., 1980, Diabetes mellitus in the KK mouse: Similarities and differences between genetic and other types of diabetes. In Secondary Diabetes: The spectrum of the diabetic syndromes, Podolsky, S. and Viswanathan, M., Eds., New York, Raven Press, 455–469.

    Google Scholar 

  6. Nakamura, M., and Yamada, K., 1963, A further study of the diabetic (KK) strain of the mouse. Proc Jap Acad 39: 489–493.

    Google Scholar 

  7. Butler, L., and Gerritsen, G.G., 1970, A comparison of the modes of inheritance of diabetes in the Chinese hamster and the KK mouse. Diabeto- logia 6: 163–167.

    Article  CAS  Google Scholar 

  8. Morii, F., Hattori, M., Miyazaki, E., Fukuchi, S., and Tsukahara, I., 1974, Histological studies on congenitally diabetic KK mice., 1974, Folea Ophthalmol Jap 25: 372–389.

    Google Scholar 

  9. Miyazaki, E., Morii, F., and Yamashita, H., 1975, Histological studies on congenitally diabetic KK mice. Report 2. Electron microscope study findings concerning the optic nerve. J Jap Diab Soc 18: 101–104.

    Google Scholar 

  10. Reddi, A.S., Oppermann, W., Velasco, C.A., Strugatz, L.H., and Camerini-Davalos, R.A., 1975, Early genetic diabetes in the KK mouse. In Early Diabetes in Early Life, Camerini-Davalos, R.A. and Cole, H.S., Eds., New York, Academic Press: 413–425.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Reddi, A.S., Camerini-Davalos, R.A. (1988). Hereditary Diabetes in the KK Mouse: An Overview. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5616-5_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5618-9

  • Online ISBN: 978-1-4684-5616-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics