Abstract
Type 1 (insulin-dependent) diabetes is a disease characterized by a prodromal period with beta-cell destruction mediated by mononuclear white blood cells and their products. Several markers have been identifyed to characterize the prodromal phase of the disease. During this phase alterations involving lymphocyte activation are present; an increased percentage of circulating activated lymphocytes is detectable and these cells show a decreased interlukin (IL2) production (1) together with an increased release of IL2 receptors (IL2R) which can be detected in serum (2).
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© 1988 Plenum Press, New York
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Signore, A., Pozzilli, P., Tamburrano, G., Andreani, D. (1988). The in Vivo Visualization of Insulitis a New Marker of Prediabetes. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_15
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DOI: https://doi.org/10.1007/978-1-4684-5616-5_15
Publisher Name: Springer, Boston, MA
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