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A New Marker of T Lymphocyte Activation in Type I Diabetes

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Prediabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 246))

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Abstract

Biological changes underlying T lymphocyte activation, are known to be complex and are still poorly understood (1). Prominent in the early activation-related phenomena (minutes to a few hours after the activation signal) are the elevation of cytoplasmic calcium and changes in transmembrane electrical potential (TMP) (2–4). Resting T lymphocytes possess a relatively constant TMP. However, following mitogen or antigen challenge, T cell TMP changes over several minutes to hours with consecutive periods of depolarization, repolarization and hyperpolarization (2). Selective membrane NA, K-ATP-ase, and the K and Na permeable channels, abrogate both the TMP changes and T cell activation indicating a relationship between them and suggesting that cell membrance depolarization is an integral part of cell activation (2).

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References

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Author information

Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA

    John Cavanaugh, Neil E. Kay, Jaume Binimelis, Alberto de Leiva & Jose Barbosa

  2. Division of Hematology and Oncology Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota, USA

    John Cavanaugh, Neil E. Kay, Jaume Binimelis, Alberto de Leiva & Jose Barbosa

Authors
  1. John Cavanaugh
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  2. Neil E. Kay
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  3. Jaume Binimelis
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  4. Alberto de Leiva
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  5. Jose Barbosa
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Editor information

Editors and Affiliations

  1. Diabetes Prevention Research Program, New York Medical College, Metropolitan Hospital Research Center, New York, New York, USA

    Rafael A. Camerini-Davalos

  2. Departments of Community and Preventive Medicine and Pediatrics, New York Medical College, Valhalla, New York, USA

    Harold S. Cole

  3. Bronx Developmental Center, Office of Mental Retardation and Developmental Disabilities of the State of New York, Bronx, New York, USA

    Harold S. Cole

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© 1988 Plenum Press, New York

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Cavanaugh, J., Kay, N.E., Binimelis, J., de Leiva, A., Barbosa, J. (1988). A New Marker of T Lymphocyte Activation in Type I Diabetes. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_10

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  • DOI: https://doi.org/10.1007/978-1-4684-5616-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5618-9

  • Online ISBN: 978-1-4684-5616-5

  • eBook Packages: Springer Book Archive

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