Skip to main content
SpringerLink
Log in

Clinical Experience with 5-FU/DDP ± OHDW Combination Chemotherapy in Patients with Advanced Colorectal Carcinoma

  • Chapter
  • First Online:
The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 244))

Abstract

Many avenues are being explored in an effort to develop more effective and selective treatment of patients with advanced colorectal carcinoma. One approach termed biochemical modulation is based on “immortal”, although minimal, 5-fluorouracil (5-FU) activity. At least six types of modulation have been attempted based on the current understating of 5-FU metabolism: 1) Methotrexate, 2) Thymidine, 3) PALA, 4) Allopurinol, 5) Folinic acid (FA), and 6) cisPlatin (DDP).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Y.M. Rustum, S. Madajewicz, J. Campbell, S. Zakrzewski, N, Petrelli, L.O. Herrera, A. Mittelman, P.J. Creaven. Clinical biochemical pharmacology 5-formyltetrahydrofolate in combination with 5-fluorouracil in patients with advanced colorectal carcinoma: correlation with clinical response, In: Advances in Cancer Chemotherapy. The Current Status of 5-FluorouracilLeucovorin Calcium Combination. H.W. Bruckner and Y.M. Rustum, eds., Div. of Park Row Publishers (1984).

    Google Scholar 

  2. K.J. Scanlon, R.L. Safirstein, H. Thies, R.B. Gross, S. Waxman, J.B. Guttenplan. Inhibition of amino acid transport by cis-diamminedichloroplatinum(II) derivatives in L1210 murine leukemia cells.. Cancer Res. 43: 4211 (1983).

    CAS  PubMed  Google Scholar 

  3. H.A. Krebs, R. Hems, B. Tyler. The regulation of folate and methionine metabolism. Biochem. J. 158: 341 (1976).

    Article  CAS  Google Scholar 

  4. K.J. Scanlon, E.M. Newman, Y. Lu, D.G. Priest. Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells. Proc. Natl. Acad. Sci. 83: 8923 (1986).

    Article  CAS  Google Scholar 

  5. J.L. Aull, A.C. Rice, L.A. Tebbetts, Interactions of platinum complexes with the essential and non-essential sulfhydryl groups of thymidylate synthetase. Biochem. 16:672 (1977)

    Article  CAS  Google Scholar 

  6. S. Madajewicz, F. Trave, N. Petrelli, Y. Rustum, L. Herrera, A. Mittelman, P. Creaven. Preclinical and clinical studies with 5-fluorouracil and cisplatin. Proc. Am. Soc. Clin. Oncol. 4: 47 (1985).

    Google Scholar 

  7. J. Cantrell, R. Hart, R. Taylor, J. Harvey. A phase II trial of continuous infusion 5-FU and weekly low dose cisplatin in colorectal carcinoma. Proc. Am. Soc. Clin. Oncol. 5: 84 (1986).

    Google Scholar 

  8. A. Lockshin, P.V. Danenberg. Biochemical factors affecting the tightness of 5-f luorodeoxyuridylate binding of human thymidylate synthetase. Biochem. Pharmacol. 30: 247 (1980).

    Article  Google Scholar 

  9. S. Madajewicz, N. Petrelli, Y.M. Rustum, J. Campbell, L. Herrera, A. Mittelman, A. Perry, P.J. Creaven. Phase I-II trial of high dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer. Cancer Res. 44: 4667 (1984).

    CAS  PubMed  Google Scholar 

  10. D. Machover, E. Goldschmidt, P. Chollet, G. Metzger, J. Zittoun, J. Marquet, J.M. Vandenbulcke, J.L. Misset, L. Schwarzenberg, J.B. Fourtillan, H. Gaget, G. Mathe. Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid. J. Clin. Onc. 4: 685 (1986).

    Article  CAS  Google Scholar 

  11. J.A. Houghton, S.J. Maroda, J.O. Phillips, P.J. Houghton. Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenographs of human colorectal adenocarcinoms in mice. Cancer Res. 41: 144 (1981).

    CAS  PubMed  Google Scholar 

  12. K. Keyomarsi, R.G. Moran. Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res. 46: 5229 (1986).

    CAS  PubMed  Google Scholar 

  13. E.E. Vokes, K.E. Choi, R.L. Schilsky, W. Moran, C.M. Guarnieri, R.R. Weichselbaum, W.R. Panje. Cisplatin, fluorouracil, and high-dose leucovorin for recurrent or metastatic head and neck cancer. J. Clin. Oncol. 6: 618 (1988).

    Article  CAS  Google Scholar 

  14. H.S. Krebs, R. Hems, B. Tyler. The regulation of folate and methionine metabolism. Biochem. J. 158: 341 (1976).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Oncology, Health Sciences Center, State University of New York at Stony Brook, T-17, 080, Stony Brook, NY, 11794-8174, USA

    Stefan Madajewicz, John J. Fiore & Mohammad H. Zarrabi

Authors
  1. Stefan Madajewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John J. Fiore
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohammad H. Zarrabi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, Buffalo, New York, USA

    Youcef Rustum  & John J. McGuire  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Madajewicz, S., Fiore, J.J., Zarrabi, M.H. (1988). Clinical Experience with 5-FU/DDP ± OHDW Combination Chemotherapy in Patients with Advanced Colorectal Carcinoma. In: Rustum, Y., McGuire, J.J. (eds) The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. Advances in Experimental Medicine and Biology, vol 244. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5607-3_32

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5607-3_32

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-5609-7

  • Online ISBN: 978-1-4684-5607-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation