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Progress Report on Studies of FAM-CF for Gastric Cancer and Intraperitoneal Administration of FUra-CF Followed by Cisplatin (DDP)

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The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 244))

Abstract

Randomized controlled trials have demonstrated that the response rate to 5-fluorouracil (FUra) in combination with leucovorin (CF) is approximately two-fold higher than the response rate to single agent FUra in patients with colorectal carcinoma (1–5). Since FUra alone has activity in other gastrointestinal cancers, our work has been directed toward evaluating the role of this combination for the treatment of other gastrointestinal cancers, using both the intravenous (IV) and intraperitoneal (IP) routes.

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References

  1. Doroshow JH, Bertrand M, Multhauf P, et al: Prospective Randomized Trial of 5-FU versus 5-FU and High-Dose Folinic Acid (HDFA) for Treatment of Advanced Colorectal Cancer. Proc Am Soc Clin Oncol 6: 96, 1987

    Google Scholar 

  2. Petrelli N, Herrera L, Rustum YM, et al: A Prospective Randomized Trial of 5-Fluorouracil versus 5-Fluorouracil and High-Dose Leucovorin versus 5-Fluorouracil and Methotrexate in Previously Untreated Patients with Advanced Colorectal Carcinoma. J Clin Oncol 5: 1559–1565, 1987

    Article  CAS  Google Scholar 

  3. Erlichman C, Fine S, Wong A, et al: A Randomized Trial of Fluorouracil and Folinic Acid in Patients with Metastatic Colorectal Cancer. J Clin Oncol 6: 469–475, 1988

    Article  CAS  Google Scholar 

  4. Petrelli N, Stablein D, Bruckner H, et al: Phase III Evaluation of 5-Fluorouracil (5-FU) vs 5-FU and High-Dose Leucovorin (HDCF) vs 5-FU and Low-Dose Leucovorin (LDCF) in Patients with Metastatic Colorectal Adenocarcinoma. A Report of the Gastrointestinal Tumor Study Group. Proc Am Soc Clin Oncol, In Press, 1988

    Google Scholar 

  5. O’Connell MJ and Wieand HS: A Controlled Clinical Trial Including Folinic Acid at Two Distinct Dose Levels in Combination with 5-Fluorouracil (5FU) for the Treatment of Advanced Colorectal Cancer: Experience of the Mayo Clinic and North Central Cancer Treatment Group, Proceedings of the International Symposium on “The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy”. Buffalo, NY, April 1988

    Google Scholar 

  6. Arbuck SG, Douglass HO Jr, Trave F, et al: A Phase II Trial of 5-Fluorouracil and High-Dose Intravenous Leucovorin in Gastric Carcinoma. J Clin Oncol 5: 1150–1156, 1987

    Article  CAS  Google Scholar 

  7. Machover D, Goldschmidt E, Chollet P, et al: Treatment of Advanced Colorectal and Gastric Adenocarcinomas with 5-Fluorouracil and High Dose Folinic Acid. J Clin Oncol 4: 685–696, 1986

    Article  CAS  Google Scholar 

  8. MacDonald JS, Schein PS, Wooley PV: 5-Fluorouracil, Doxorubicin and Mitomycin (FAM) Combination Chemotherapy for Advanced Gastric Cancer. Ann Intern Med 93: 533–536, 1980

    Article  Google Scholar 

  9. Speyer, JL, Collins JM, Dedrick, R L, et al: Phase I and Pharmacological Studies of 5-Fluorouracil Administered Intraperitoneally. Cancer Res 40: 567–572, 1980

    CAS  PubMed  Google Scholar 

  10. Arbuck SG, Trave F, Douglass HO, Jr, et al: Phase I and Pharmacologic Studies of Intraperitoneal Leucovorin and 5-Fluorouracil in Patients with Advanced Cancer. J Clin Oncol 4: 1510–1517, 1986

    Article  CAS  Google Scholar 

  11. Speyer, JL, Sugarbaker PH, Collins, JM, et al: Portal Levels and Hepatic Clearance of 5-Fluorouracil After Intraperitoneal Administration in Humans. Cancer Res 41: 1916–1922, 1981

    CAS  PubMed  Google Scholar 

  12. Taylor I, Machin D, Mullee M: A Randomized Controlled Trial of Adjuvant Portal Vein Cytotoxic Perfusion in Colorectal Cancer. Br J Surg 72: 359–363, 1985

    Article  CAS  Google Scholar 

  13. Trave F, Rustum YM, Goranson J: Synergistic Antitumor Activity of Cisplatin (DDP) and 5-Fluorouracil in Mice Bearing Leukemia L1210 Cells. Proc Am Assoc Cancer Res 26: 322, 1985

    Google Scholar 

  14. Rustum YM, Trave F: Personal Communication

    Google Scholar 

  15. Dunnick, NR, Jones RB, Doppman JL, et al: Intraperitoneal Contrast Infusion for Assessment of Intraperitoneal Fluid Dynamics. Am J Rad 133: 221–223, 1979

    CAS  Google Scholar 

  16. Douglass, HO Jr, Lavin PT, Goudsmit A, et al: An Eastern Cooperative Oncology Group Evaluation of Combinations of Methyl-CCNU, Mitomycin C, Adriamycin, and 5-Fluorouracil in Advanced Measurable Gastric Cancer (EST 2277). J Clin Onc 2: 1372–1381, 1984

    Article  Google Scholar 

  17. Ozols RF, Locker GY, Doroshow JH, et al: Pharmacokinetics of Adriamycin and Tissue Penetration in Murine Ovarian Cancer. Cancer Res 39: 3209–3214, 1979

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Roswell Park Memorial Institute, 666 Elm St., Buffalo, NY, 14263, USA

    S. G. Arbuck, H. O. Douglass Jr., H. R. Nava, Y. N. Silk, M. Baroni & Y. M. Rustum

Authors
  1. S. G. Arbuck
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  2. H. O. Douglass Jr.
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  3. H. R. Nava
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  4. Y. N. Silk
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  5. M. Baroni
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  6. Y. M. Rustum
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Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, Buffalo, New York, USA

    Youcef Rustum  & John J. McGuire  & 

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© 1988 Plenum Press, New York

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Arbuck, S.G., Douglass, H.O., Nava, H.R., Silk, Y.N., Baroni, M., Rustum, Y.M. (1988). Progress Report on Studies of FAM-CF for Gastric Cancer and Intraperitoneal Administration of FUra-CF Followed by Cisplatin (DDP). In: Rustum, Y., McGuire, J.J. (eds) The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. Advances in Experimental Medicine and Biology, vol 244. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5607-3_31

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  • DOI: https://doi.org/10.1007/978-1-4684-5607-3_31

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-5609-7

  • Online ISBN: 978-1-4684-5607-3

  • eBook Packages: Springer Book Archive

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