Abstract
Phorbol esters have been shown to cause a slowly developing and sustained contraction of vascular smooth muscle from a variety of species (Rasmussenet al., 1984; Danthuluri and Deth, 1984; Forderet al., 1985; Gleason and Flaim, 1986; Sybertzet al., 1986; Chatterjee and Tejada, 1986). This action of phorbol esters is presumed to be due to stimulation of protein kinase C., a Ca2+ -phospholipid-dependent protein kinase (Nishizuka, 1984; Castagnaet al., 1982). Phorbol ester-stimulated vascular smooth muscle contraction in many systems is dependent on extracellular Ca2+ (Rasmussenet al., 1984; Danthuluri and Deth, 1984; Forderet al., 1985; Gleason and Flaim, 1986). In rabbit aorta, phorbol-stimulated contraction is inhibited by organic Ca2+ channel antagonists, and is facilitated by the Ca2+ channel agonist BAY K 8644 or by an increase in extracellular Ca2+ concentration (Forderet al., 1985).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Castagna, M., Takai, Y., Taibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y., 1982, Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters, J. Biol. Chem. 257:1847–1851.
Chatterjee, M. and Tejada, M., 1986, Phorbol ester-induced contraction in chemically-skinned vascular smooth muscle, Am. J. Physiol. 251:C356–C361.
Danthuluri, N. R., and Deth, R. C., 1984, Phorbol ester-induced contraction of arterial smooth muscle and inhibition of alpha-adrenergic response, Biochem. Biophys. Res. Commun. 125:1103–1109.
DeRiemer, S. A., Strong, J. A., Albert, K. A., Greengard, D., and Kaczmarek, L. K., 1985, En hancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C., Nature 313:313–316.
Forder, J., Scriabine, A., and Rasmussen, H., 1985, Plasma membrane calcium flux, protein kinase C activation and smooth muscle contraction, J. Pharmacol. Exp. Ther. 235:267–273.
Farley, J., and Auerbach, S., 1985, Protein kinase C activation induces conductance changes in Her-missenda photoreceptors like those seen in associative learning, Nature 319:220–223.
Fish, R. D., Sperti, G., Colucci, W. S., and Clapham, D. E., 1988, Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line, Circ. Res. 62:1049–1054.
Friedman, M. E., Suarez-Kurtz, G., Kaczorowski, G. J., Katz, G. M., and Reuben, J. P., 1986, Two calcium currents in a smooth muscle cell line, Am. J. Physiol. 250:H699–H703.
Galazzi, J. P., Qar, J., Fosset, M., Van Renterghem, C., and Lazdunski, M., 1987, Regulation of calcium channels in aortic muscle cells by protein kinase-C activators and by peptides that stimulate phosphoinositide breakdown, J. Biol. Chem. 262:6947–6950.
Gleason, M. M., and Flaim, S. F., 1986, Phorbol ester contracts rabbit thoracic aorta by increasing intracellular calcium and by activating calcium influx, Biochem. Biophys. Res. Commun. 138: 1362–1369.
Higashida, H., and Brown, D. A., 1986, Two polysphatidylinositide metabolites control two K + currents in a neuronal cell, Nature 323:333–335.
Kimes, B. W., and Brandt, B. L., 1976, Characterization of two putative smooth muscle cell lines from rat thoracic aorta, Exp. Cell Res. 98:349–366.
Kurtz, A., Pfeilschifter, J., Hutter, A., Buhrle, C., Nobiling, R., Taugner, R., Hachenthal, E., and Bauer, C., 1986, Role of protein kinase-C in inhibition in renin release caused by vasoconstrictors, Am. J. Physiol. 250(Cell Physiol. 19):C563–C571.
Nishizuka, Y., 1984, The role of protein kinase C in cell surface signal transduction and tumour promotion, Nature 308:693–698.
Rane, S. G., and Dunlap, K., 1986, Kinase C activator 1,2-oleoylacetyl-glycerol attenuates voltagedependent calcium current in sensory neurons, Proc. Natl. Acad. Sci. USA 83:184–188.
Rasmussen, H., 1986, The calcium messenger system, N. Engl. J. Med. 314:1094–11011, 1164–1170.
Rasmussen, H., Forder, J., Kojima, and Scriabine, A., 1984, TPA-induced contraction of isolated rabbit vascular smooth muscle, Biochem. Biophys. Res. Commun. 122:776–784.
Ruegg, U. T., 1986, Activation of potential operated calcium channels by activation of protein kinase C. 11th Scientific Meeting of the International Society of Hypertension, August 31-September 6, 1986, Heidelberg, Federal Republic of Germany (abstract).
Ruegg, U. T., Doyle, V. M., Zuber, J. F., and Hof, R. P., 1985, A smooth muscle cell line suitable for the study of voltage sensitive calcium channels, Biochem. Biophys. Res. Commun. 130:447–453.
Sperti, G., and Colucci, W. S., 1987a, Ca2+ channel antagonists inhibit DNA synthesis and proliferation in A7r5 vascular smooth muscle cells, Fed. Proc. 46:974 (abstract).
Sperti, G., and Colucci, W. S., 1987b, Phorbol-stimulated bidirectional transmembrane Ca2+ flux in A7r5 vascular smooth muscle cells, Mol. Pharmacol. 32:37–42.
Sybertz, E. J., Desiderio, D. M., Tetzloff, G., and Chiu, P. J. S., 1986, Phorbol dibutyrate contractions in rabbit aorta: Calcium dependence and sensitivity to nitrovasodilators and 8-BR-cyclic GMP, J. Pharmacol. Exp. Ther. 239:78–83.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Colucci, W.S., Sperti, G. (1989). Phorbol Esters Stimulate Calcium Influx via Voltage-Dependent Channels in A7r5 Vascular Smooth-Muscle Cells. In: Fiskum, G. (eds) Cell Calcium Metabolism. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5598-4_9
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5598-4_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5600-4
Online ISBN: 978-1-4684-5598-4
eBook Packages: Springer Book Archive