Abstract
Insulin-like growth factors (IGFs) are potent mitogens in mammalian cells (Zapfet al., 1981). The mode of action of IGFs has been extensively studied in Balb/c 3T3 cells. Thus, IGFs promote cell cycle progression specifically in competent Balb/c 3T3 cells while IGFs have essentially no effect in Go-arrested cells (Pledgeret al., 1977; Stileset al., 1979). To promote cell cycle progression, IGFs should be exposed to competent cells continuously throughout the Giphase (Pledgeret al., 1977). Hence, it is presumed that IGFs may generate a continuous mitogenic signal. This observation together with the fact that extracellular calcium is required for cell cycle progression have led to the consideration that calcium influx may be a mitogenic signal of IGFs.
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© 1989 Plenum Press, New York
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Nishimoto, I., Ogata, E., Kojima, I. (1989). Insulin-like Growth Factor II Stimulates Calcium Influx in Competent Balb/c 3T3 Cells Primed with Epidermal Growth Factor. In: Fiskum, G. (eds) Cell Calcium Metabolism. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5598-4_28
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DOI: https://doi.org/10.1007/978-1-4684-5598-4_28
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