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Regulation of Hepatic Glycogenolysis by Calcium-Mobilizing Hormones

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Cell Calcium Metabolism

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Abstract

The hormonal regulation of glycogen metabolism in the liver has been a subject of investigation for more than 30 years. The intracellular mediators responsible for this regulation have been identified as cAMP and Ca2+ . In the liver, several hormones such as vasopressin, angiotensin II, epidermal growth factor (Boschet al., 1986), glucagon (Blackmore and Exton, 1986),α 1-adrenergic agonists and P2purinergic agonists (Charestet al., 1985a,b) increase free cytosolic Ca2+ ([Ca2+ ]i). Each of these hormones binds to specific cell surface receptors; this interaction then leads to the activation of a guanine nucleotide-binding protein (Gp) (e.g., Blackmoreet al., 1985; Uhinget al., 1986). In the case of glucagon and epidermal growth factor, the mechanism of activation of Gpis not known but probably involves phosphorylation of Gp(Boschet al., 1986; Johnsonet al., 1986; Blackmore and Exton, 1986). This coupling protein then activates a specific phospholipase C which catalyzes the breakdown of phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) (Creba et al., 1983; Rhodeset al., 1983; Thomaset al., 1983; Litoschet al., 1983). The hydrolysis of PI-4,5-P2yields myoinositol-1,4,5-trisphosphate (Ins-1,4,5-P3) (Thomaset al., 1984) and 1,2-diacylglycerol (DAG) (Bocckinoet al., 1985). The Ins-1,4,5-P3releases Ca2+ from the endoplasmic reticulum into the cytoplasm (Josephet al., 1984), while DAG activates a Ca2+ -and phospholipid-dependent protein kinase (protein kinase C) in the plasma membrane (Nishizuka, 1984; Berridge, 1984).

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Authors and Affiliations

  1. Department of Pharmacology, Eastern Virginia Medical School, Norfolk, Virginia, 23501, USA

    Peter F. Blackmore

  2. Howard Hughes Medical Institute Laboratories, and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    Christopher J. Lynch, Stephen B. Bocckino & John H. Exton

Authors
  1. Peter F. Blackmore
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  2. Christopher J. Lynch
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  3. Stephen B. Bocckino
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  4. John H. Exton
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Editors and Affiliations

  1. Departments of Biochemistry and Emergency Medicine, The George Washington University School of Medicine and Health Sciences, Washington, D.C., 20037, USA

    Gary Fiskum

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© 1989 Plenum Press, New York

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Blackmore, P.F., Lynch, C.J., Bocckino, S.B., Exton, J.H. (1989). Regulation of Hepatic Glycogenolysis by Calcium-Mobilizing Hormones. In: Fiskum, G. (eds) Cell Calcium Metabolism. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5598-4_19

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  • DOI: https://doi.org/10.1007/978-1-4684-5598-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5600-4

  • Online ISBN: 978-1-4684-5598-4

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