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Immunomodulation by Hepatitis B and Related Viruses

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Virus-Induced Immunosuppression

Part of the book series: Infectious agents and pathogenesis ((IAPA))

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Abstract

Immunodeficiency disorders may occur as a result of one or more defects within the immune system spanning stem cell deficiencies, through immunoregulatory dysfunction, to a restricted failure to recognize or mount an immune response against certain antigens. The identification of these defects is complicated by their secondary effects, or by opportunistic infections in the immunocompromised host. Although the extent to which viral infections can initiate these deficits remains to be evaluated in most cases, the active role of many viruses in inducing immunosuppression is well established.

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References

  1. Blum, H. E., L. Stowring, A. Figus, C. K. Montgomery, A. T. Haase, and G. N. Vyas. Detection of hepatitis B virus DNA in hepatocytes, bile duct epithelium, and vascular elements by in situ hybridization, Proc. Natl Acad. Sci. USA 80:6682–6685 (1983).

    Google Scholar 

  2. Chong-Jin, O. and D. Jenk-Ling, Hepatitis B virus in lymphocytes of seronegative car riers, Lancet 1:395–396 (1984).

    Article  Google Scholar 

  3. Laure, F., D. Zagury, A. G. Saimot, R. C. Gallo, B. H. Hahn, and C. Brechot, Hepatitis B virus DNA sequences in lymphoid cells from patients with AIDS and AIDS-related complex, Science 229:561–563 (1985).

    Article  PubMed  CAS  Google Scholar 

  4. Lie-Injo, L. E., M. Balasegaram, C. G. Lopez, and A. R. Herrera, Hepatitis B viral DNA in liver and white blood cells of patients with hepatoma, DNA 2:301–308 (1983).

    Article  PubMed  CAS  Google Scholar 

  5. Pontisso, P., M. C. Poon, P. Tiollais, and C. Brechot, Detection of hepatitis B virus DNA in mononuclear blood cells, Br. Med. J. 288:1563–1566 (1984).

    Article  CAS  Google Scholar 

  6. Romet-Lemonne, J. L., E. Elfassi, W. Haseltine, and M. Essex, Infection of bone marrow cells by hepatitis B virus, Lancet 2:732 (1983).

    Article  PubMed  CAS  Google Scholar 

  7. Romet-Lemonne, J. L., M. F. McLane, E. Elfassi, W. Haseltine, J. Azocar, and M. Essex, Hepatitis B virus infection in cultured human lymphoblastoid cells, Science 221:667–669 (1983).

    Article  PubMed  CAS  Google Scholar 

  8. Summers, J. and W. Mason, Replication of the genome of a hepatitis B-like virus by reverse transcriptase of an RNA intermediate, Cell 29:403–415 (1982).

    Article  PubMed  CAS  Google Scholar 

  9. Korba, B. E., F. Wells, B. C. Tennat, G. H. Yoakum, R. H. Purcell and J. L. Gerin, Hepadnavirus infection of peripheral blood lymphocytes in vivo: Woodchuck and chimpanzee models of viral hepatitis,/. Virol. 58:1–8 (1986).

    PubMed  CAS  Google Scholar 

  10. Melnick, J. L., Classification of hepatitis A virus as enterovirus type 72 and hepatitis B as a hepadnavirus type 1, Intervirology 18:105–106 (1982).

    Article  PubMed  CAS  Google Scholar 

  11. Robinson, W. S., P. Marion, M. Feitelson, and A. Siddiqui, The hepadnavirus group: Hepatitis B and related viruses, in: Viral Hepatitis ,1981 International Symposium (W. Szmuness, H. J. Alter, and J. E. Maynard, eds.), pp. 57–68, Franklin Institute Press, Philadelphia (1982).

    Google Scholar 

  12. Summers, J., J. Smolec, and R. Snyder, A virus similar to hepatitis B associated with hepatitis and hepatoma in woodchucks, Proc. Natl. Acad. Sci. USA 75:4523–4537 (1978).

    Article  Google Scholar 

  13. Marion, P. L., L. S. Oshiro, D. C. Regnery, G. H. Scullard, and W. S. Robinson, A virus in Beechy ground squirrels that is related to hepatitis B virus of humans, Proc. Natl. Acad. Sci. USA 77:2941–2945 (1980).

    Article  PubMed  CAS  Google Scholar 

  14. Mason, W. S., G. Seal, and J. Summers, Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus, J. Virol. 35:829–836 (1980).

    Google Scholar 

  15. Cote, P. J., Jr., G. M. Dapolito, J. W-K. Shin, and J. L. Gerin, Surface antigenic determi nants of mammalian “hepadnavirus” defined by group and class-specific monoclonal antibodies,/. Virol. 3:135–142 (1982).

    Google Scholar 

  16. Howard, C. R., The nature of the hepatitis B virus and its mode of replication, Springer Semin. Immunopathol. 3:397–419 (1981).

    Article  PubMed  CAS  Google Scholar 

  17. Chernesky, M. A., M. R. Escobar, P. D. Swenson, and S. Specter, Laboratory diagnosis of hepatitis viruses, Cumitech 18:1–12 (1984).

    Google Scholar 

  18. LeBouvier, G. L., The heterogeneity of Australia antigen, J. Infect. Dis. 123:671–675 (1971).

    Article  CAS  Google Scholar 

  19. Bancroft, W. A., F. F. Mundon, and P. K. Russel, Detection of additional antigenic determinants of hepatitis B antigen, J. Immunol. 109:842–848 (1972).

    PubMed  CAS  Google Scholar 

  20. Heermann, K. H., U. Goldman, W. Schwartz, T. Seyffarth, H. Baumgarten, and W. H. Gerlich, Large surface proteins of hepatitis B virus containing the pre-S sequence, J. Virol. 52:396–401 (1984).

    PubMed  CAS  Google Scholar 

  21. Stibbe, W. and W. H. Gerlich, Variable protein composition of hepatitis B surface antigen from different donors, Virology 123:436–442 (1982).

    Article  PubMed  CAS  Google Scholar 

  22. Tiollais, P, P. Charnay, and G. N. Vyas, Biology of hepatitis B virus, Science 213:406–411 (1981).

    Article  PubMed  CAS  Google Scholar 

  23. Machida, A., S. Kishimoto, H. Ohnuma, K. Baba, Y. Ito, H. Miyamoto, G. Funatsu, K. Oda, S. Usuda, S. Togami, T. Nakamura, M. Miyakawa, and M. Mayumi, A polypeptide containing 55 amino acid residues coded by the pre-S region of hepatitis B virus deoxyribonucleic acid bears the receptor for polymerized human as well as chimpanzee albumins, Gastroenterology 86:910–918 (1984).

    PubMed  CAS  Google Scholar 

  24. Stibbe, W. and W. H. Gerlich, Structural relationships between minor and major proteins of hepatitis B surface antigen, J. Virol. 46:626–628 (1983).

    PubMed  CAS  Google Scholar 

  25. Takahashi, K., Y. Akahane, T. Gotanda, T. Mishiro, M. Imai, Y. Miyakawa, and N. Mayumi, Demonstration of hepatitis B e antigen in the core of Dane particles, J. Immunol. 122:275–279 (1979).

    PubMed  CAS  Google Scholar 

  26. Yoshizawa, H., Y. Itoh, J. P. Simonetti, T. Takahashi, A. Machida, Y. Miyakawa, and M. Mayumi, Demonstration of hepatitis B e antigen in hepatitis B core particles obtained from the nucleus of hepatocytes infected with hepatitis B virus, J. Gen. Virol. 42:513–519 (1979).

    Article  PubMed  CAS  Google Scholar 

  27. Murphy, B., E. Tabor, V. McAuliffe, A. Williams, J. Maynard, R. Gerety, and R. Purcell, Third component, HBeAg/3, of hepatitis B e antigen system identified by the different double diffusion techniques,/. Clin. Microbiol. 8:349–350 (1978).

    PubMed  CAS  Google Scholar 

  28. Williams, A. and G. L. LeBouvier, Heterogeneity and thermolability of “e” antigen, Bibl. Haematol. 42:71–75 (1976).

    PubMed  CAS  Google Scholar 

  29. Imai, M., M. Nomura, T. Gotanda, T. Sano, K. Tachibana, H. Miyamoto, K. Takahashi, S. Toyama, Y. Miyakawa, and M. Mayumi, Demonstration of two distinct antigenic determinants on hepatitis B e antigen by monoclonal antibodies, J. Immunol. 128:69–72 (1982).

    PubMed  CAS  Google Scholar 

  30. Summers, J., Replication of hepatitis B viruses, in Viral Hepatitis and Liver Disease (G. N. Vyas, J. L. Dienstag, and J. H. Hoofnagle, eds.), pp. 87–96, Grune &Stratton, Orlando, Florida (1984).

    Google Scholar 

  31. Escobar, M. R. and P. D. Swenson, Mechanisms of viral immunopathology with special reference to viral hepatitis, in Immunomodulation by Microbial Products and Related Synthetic Compounds (Y. Yamamura, S. Kotani, I. Azuma, A. Koda, and T. Shiba, eds.), pp. 134–147, Excerpta Medica, Amsterdam (1982).

    Google Scholar 

  32. Blumberg, B. S., Comments on the biology of HBV, in Viral Hepatitis (G. N. Vyas, S. N. Cohen, and R. Schmid, eds.), pp. 591–592, The Franklin Institute Press, Philadelphia (1978).

    Google Scholar 

  33. Walker, M. E., W. Szmuness, C. Stevens, and P. Rubenstein, Genetics of anti-HBs responsiveness. I. HLA-DR7 and nonresponsiveness to hepatitis vaccination, Transfusion 21:601 (1981) (abst.).

    Google Scholar 

  34. Milich, D. R., H. Alexander, and F. V. Chisari, Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). III. Circumvention of nonrespon siveness in mice bearing HBsAg nonresponder haplotypes, J. Immunol. 130:1401–1407 (1983).

    PubMed  CAS  Google Scholar 

  35. Milich, D. R. and F. V. Chisari, Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). I. H-2 restriction of the murine humoral immune response to a and d determinants of HBsAg, J. Immunol. 129:320–325 (1982).

    PubMed  CAS  Google Scholar 

  36. Milich, D. R., G. G. Leroux-Roels, and F. V. Chisari, Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). II. Qualitative characteristics of the humoral immune response to the a, d ,and y determinants of HBsAg, J. Immunol. 130:1395–1400 (1983).

    PubMed  CAS  Google Scholar 

  37. Szmuness, W., C. E. Stevens, E. A. Zang, E. J. Harley, and A. Kellner. A control clinical trial of the efficacy of the hepatitis B vaccine (Heptavax B): A final report, Hepatology 1:377–385 (1981).

    Article  PubMed  CAS  Google Scholar 

  38. Montano, L., G. C. Miescher, A. H. Goodall, K. H. Wiedmann, G. Janossy, and H. C. Thomas, Hepatitis B virus and HLA antigen display in the liver during chronic hepatitis B virus infection, Hepatology 2:557–561 (1982).

    Article  PubMed  CAS  Google Scholar 

  39. Dienstag, J. L., Immunologic mechanisms in chronic viral hepatitis, in Viral Hepatitis and Liver Disease (G. N. Vyas, J. L. Dienstag, and J. H. Hoofnagle, eds.), pp. 135–166, Grune &Stratton, Orlando (1984).

    Google Scholar 

  40. Craxi, A., L. Montano, A. Goodall, and H. C. Thomas, Genetic and sex-linked factors influencing HBs antigen clearance. I. Nonimmune clearance in inbred strains of mice, J. Med. Virol. 9:117–123 (1982).

    Article  PubMed  CAS  Google Scholar 

  41. Klingenstein, R.J. and J. L. Dienstag, Immunopathogenesis of acute and chronic hepatitis B, in Hepatitis B (R. J. Gerety, ed.), pp. 221–245, Academic, Orlando (1985).

    Google Scholar 

  42. Smith, C. I., W. G. E. Cooksley, and L. W. Powell, Cell-mediated immunity to liver antigen in toxic liver injury. I. Occurrence and specificity, Clin. Exp. Immunol. 39:607–617 (1980).

    PubMed  CAS  Google Scholar 

  43. Smith, C. I., W. G. E. Cooksley, and L. W. Powell, Cell-mediated immunity to liver antigen in toxic liver injury. II. Role in pathogenesis of liver damage, Clin. Exp. Immunol. 39:618–625 (1980).

    PubMed  CAS  Google Scholar 

  44. Blumberg, B. S., H. I. Sutnick, and W. T. London, Australia antigen as a hepatitis virus. Variation in host response. Am. J. Med. 48:1–8 (1970).

    Article  PubMed  CAS  Google Scholar 

  45. Dudley, F. J., R. A. Fox, and S. Sherlock, Cellular immunity and hepatitis-associated Australia antigen in liver disease, Lancet 1:723–726 (1972).

    Article  PubMed  CAS  Google Scholar 

  46. Serjeantson, S., and D. G. Woodfìeld, Immune response of leprosy patients to hepatitis B virus, Am. J. Epidemiol. 107:321–327 (1978).

    PubMed  CAS  Google Scholar 

  47. Chisari, F. V., J. A. Routenberg, D. S. Anderson, and T. S. Edgington, Cellular immune reactivity in HBV-induced disease, in: Viral Hepatitis (G. N. Vyas, S. N. Cohen, and R. Schmid, eds.), pp. 245–266, Franklin Institute Press, Philadelphia (1978).

    Google Scholar 

  48. Dusheiko, G. M., J. H. Hoofnagle, W. G. Cooksley, S. P. James, and E. A. Jones, Synthesis of antibodies to hepatitis B virus by cultured lymphocytes from chronic hepati tis B surface antigen carriers, J. Clin. Invest. 71:1104–1113 (1983).

    Article  PubMed  CAS  Google Scholar 

  49. Chisari, F. V., and T. S. Edgington, Lymphocyte E rosette inhibitory factor: A regulatory serum lipoprotein, J. Exp. Med. 142:1092–1107 (1975).

    Article  PubMed  CAS  Google Scholar 

  50. Celis, E., P. C. Kung, and T. W. Chang, Hepatitis B virus-reactive human T lymphocyte clones: Antigen specificity and helper function for antibody synthesis, J. Immunol. 132:1511–1516 (1984).

    PubMed  CAS  Google Scholar 

  51. Hellstrom, U., and S. Sylvan, Regulation of the immune response to hepatitis B virus and human serum albumin. I. Hepatitis B surface antigen-induced secretion of antibodies with specificity for human serum albumin in hepatitis B-immune donors in vitro, Scand.J. Immunol. 23:545–553 (1986).

    Article  PubMed  CAS  Google Scholar 

  52. Kerlin, P., K. M. Nies, and M. J. Tong, Unimpaired B-cell function and T-cell regulation of immunoglobulin synthesis in patients with chronic hepatitis B virus infection, Clin. Immunol. Immunopathol. 25:149–156 (1982).

    Article  PubMed  CAS  Google Scholar 

  53. Vento, S., J. E. Hegarty, A. Alberti, C. J. O’Brien, G. J. M. Alexander, A. L. W. F. Eddleston, and R. Williams, T-lymphocyte sensitization to HBcAg and T-cell mediated unresponsiveness to HBsAg in hepatitis B virus-related chronic liver disease, Hepatology 5:192–197 (1985).

    Article  PubMed  CAS  Google Scholar 

  54. Milich, D. R., G. B. Thornton, A. R. Neurath, S. B. Kent, M -L. Michel, P. Tiollais, and F. V. Chisari, Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen, Science 228:1195–1198 (1985).

    Article  PubMed  CAS  Google Scholar 

  55. Milich, D. R., A. McLachlan, F. V. Chisari, S. B. H. Kent, and G. B. Thornton, Immune response to the pre-S(l) region of the hepatitis B surface antigen (HBsAg): A pre-S(1) specific T cell response can bypass nonresponsiveness to the pre-S(2) and S regions of HBsAg, J. Immunol. 137:315–322 (1986).

    PubMed  CAS  Google Scholar 

  56. McAuliffe, V. J., R. H. Purcell, and J. L. Gerin, Type B hepatitis: A review of current prospects for a safe and effective vaccine, Rev. Infect. Dis. 2:470–492 (1980).

    Article  PubMed  CAS  Google Scholar 

  57. Melnick, J. L., G. R. Dreesman, and F. B. Hollinger, Approaching the control of viral hepatitis type B, J. Infect. Dis. 133:210–229 (1976).

    Article  PubMed  CAS  Google Scholar 

  58. Thomas, H. C., and D. P.Jewell, Acute and chronic viral hepatitis, in: Clinical Gastrointestinal Immunology (H. C. Thomas and D. P.Jewell, eds.), pp. 164–210, Blackwell Scientific Publications, London (1979).

    Google Scholar 

  59. Fathman, C. G., and F. W. Fitch (eds.), Isolation, Characterization and Utilization of T Lymphocyte Clones ,Academic, New York (1982).

    Google Scholar 

  60. Pernis, B. and H. J. Vogel, Regulatory T. Lymphocytes ,Academic, New York (1980).

    Google Scholar 

  61. Roberts, I. M., C. C. Bernard, G. N. Vyas, and I. R. MacKay, T-cell dependence of immune response to hepatitis B antigen in mice, Nature (Lond.) 254:606–607 (1975).

    Article  CAS  Google Scholar 

  62. Tabor, E., R. J. Gerety, L. A. Smallwood, and L. F. Barker, Coincident hepatitis B surface antigen and antibodies of different subtypes in human serum, J. Immunol. 118:369–370 (1977).

    PubMed  CAS  Google Scholar 

  63. Lane, H. C., G. Whalen, and A. S. Fauci, Dichotomy between antigen and mitogen-induced T cell help in human B cell activation, Clin. Res. 30:252 (1982) (abst.).

    Google Scholar 

  64. Machida, A., S. Kishimoto, H. Ohnuma, H. Miyamoto, K. Baba, K. Oda, T. Nakamura, Y. Miyakawa, and M. Mayumi, A hepatitis B surface antigen polypeptide (p31) with the receptor for polymerized human as well as chimpanzee albumins, Gastroenterology 85:268–274 (1983).

    PubMed  CAS  Google Scholar 

  65. Okamoto, H., M. Imai, S. Usuda, E. Tanaka, K. Tachibana, S. Mishiro, A. Machida, T. Nakamura, Y. Miyakawa, and M. Mayumi, Hemagglutination assay of polypeptide coded by the pre-S region of hepatitis B virus DNA with monoclonal antibody: Correlation of pre-S polypeptide with the receptor for polymerized human albumin in serums containing hepatitis B antigens, J. Immunol. 134:1212–1216 (1985).

    PubMed  CAS  Google Scholar 

  66. Okamoto, H. S. Usuda, M. Imai, K. Tachibana, E. Tanaka, T. Kumakura, M. Itabashi, E. Takai, F. Tsuda, T. Nakamura, Y. Miyakawa, and M. Mayumi, Antibody to the receptor for polymerized human serum albumin in acute and persistent infection with hepatitis B virus, Hepatology 6:354–359 (1986).

    Article  PubMed  CAS  Google Scholar 

  67. Yu, M. W., J. S. Finlayson, and J. W-K. Shih, Interaction between various polymerized human albumins and hepatitis B surface antigen, J. Virol. 55:736–743 (1985).

    PubMed  CAS  Google Scholar 

  68. Neurath, A. R., S. B. H. Kent, N. Strick, and K. Parker, Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus, Cell 46:429–436 (1986).

    Article  PubMed  CAS  Google Scholar 

  69. Gold, J. W. M., H. J. Alter, P. V. Holland, J. L. Gerin, and R. H. Purcell, Passive hemagglutination assay for antibody to subtypes of hepatitis B surface antigen, J. Immu nol. 112:1100–1106 (1974).

    CAS  Google Scholar 

  70. Markenson, J. A., R.J. Gerety, J. H. Hoofnagle, and L. F. Barker, Effect of a cyclophosphamide on hepatitis B virus infection and challenge on chimpanzees, J. Infect. Dis. 131:79–87 (1975).

    Article  PubMed  CAS  Google Scholar 

  71. Swenson, P. D., M. R. Escobar, R. L. Carithers, and T. J. Sobieski III, Failure of preexistent antibody against hepatitis B surface antigen to prevent subsequent hepatitis B infection, J. Clin. Microbiol. 18:305–309 (1983).

    PubMed  CAS  Google Scholar 

  72. Troisi, C. L. and F. B. Hollinger, Detection of an IgM antiidiotype directed against anti-HBs in hepatitis B patients, Hepatology 5:758–762 (1985).

    Article  PubMed  CAS  Google Scholar 

  73. Tabor, E. and R. J. Gerety, Possible role of immune responses to hepatitis B core antigen in protection against hepatitis B infection. (Letter.), Lancet 1:172 (1984).

    Article  PubMed  CAS  Google Scholar 

  74. Goudeau, A. and F. Dubois, Immune status of anti-HBc positive individuals, Lancet 1:396 (1984).

    Article  PubMed  CAS  Google Scholar 

  75. Goudeau, A., F. Dubois, F. Barin, M. D. Dubois, and P. Coursaget, Hepatitis B vaccine: Clinical trials in high-risk settings in France. (September 1975-September 1982), Dev. Biol. Std. 54:267–284 (1983).

    CAS  Google Scholar 

  76. Brechot, C., M. Hadchouel, J. Scotto, M. Fonck, F. Potet, G. N. Vyas, and P. Tiollais, State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases, Proc. Natl. Acad. Sci. USA 78:3906–3910 (1981).

    Article  PubMed  CAS  Google Scholar 

  77. Katchaki, J. N., R. Brouwer, and T. H. Siem, Anti-HBc and blood, N. Engl. J. Med. ,298:1421–1422 (1978).

    Article  PubMed  CAS  Google Scholar 

  78. Hellstrom, U. and S. Sylvan, Editorial Reviews: Human serum albumin and the enigma of chronic hepatitis type B, Scand. J. Immunol. 23:523–527 (1986).

    Article  PubMed  CAS  Google Scholar 

  79. Fakunle, Y. M., F. Aranguibel, D. De Villiers, H. C. Thomas, and S. Sherlock, Monomeric (7S) IgM in chronic liver disease, Clin. Exp. Immunol. 38:204–210 (1979).

    PubMed  CAS  Google Scholar 

  80. Sjogren, M. and J. H. Hoofnagle, Immunoglobulin M antibody to hepatitis B core antigen in patients with chronic type B hepatitis, Gastroenterology 89:252–258 (1985).

    PubMed  CAS  Google Scholar 

  81. Trevisan, A., G. Realdi, A. Alberti, G. Ongaro, E. Pornaro, and R. Meliconi, Core antigen-specific immunoglobulin G bound to the liver cell membrane in chronic hepatitis B, Gastroenterology 82:218–222 (1982).

    PubMed  CAS  Google Scholar 

  82. Pape, G. R., E. P. Rieber, J. Eisenburg, R. Hoffman, C. M. Balch, G. Baumgartner, and G. Riethmuller, Involvement of the cytotoxic/suppressor T-cell subset in liver diseases, Gastroenterology 85:657–662 (1983).

    PubMed  CAS  Google Scholar 

  83. Nouri-Aria, K. T., G. J. M. Alexander, B. Portmann, D. Vergani, A. L. W. F. Eddleston, and R. Williams, In vitro study of IgG production and concanavalin A induced suppressor cell function in acute and chronic hepatitis B virus infection, Clin. Exp. Immunol. 64:50–58 (1986).

    PubMed  CAS  Google Scholar 

  84. Klingenstein, R. J., A. M. Savarese, J. L. Dienstag, R. H. Rubin, and A. K. Bahn, Immunoregulatory T cell subsets in acute and chronic hepatitis, Hepatology 1:523 (1981) (abst.).

    Google Scholar 

  85. Thomas, H. C., D. Brown, G. Routhier, G. Janossy, P. C. Kung, G. Goldstein, and S. Sherlock, Inducer and suppressor T-cells in hepatitis B virus-induced liver disease, Hepatology 2:202–204 (1982).

    Article  PubMed  CAS  Google Scholar 

  86. Dienstag, J. L. Immunopathogenesis of acute and chronic hepatitis B, in: Hepatitis B (R. J. Gerety, ed.), pp. 221–245, Academic, Orlando, Florida (1985).

    Google Scholar 

  87. Barnaba, V., A. Musca, C. Cordova, M. Levrero, G. Ruocco, V. Albertini-Petroni, and F. Balsano, Relationship between T cell subsets and suppressor cell activity in chronic hepatitis B virus (HBV) infection, Clin. Exp. Immunol. 53:281–288 (1983).

    PubMed  CAS  Google Scholar 

  88. Hodgson, H. J. F., J. R. Wands, and K. J. Isselbacher, Alteration in suppressor cell activity in chronic active hepatitis, Proc. Natl. Acad. Sci. USA 75:1549–1553 (1978).

    Article  PubMed  CAS  Google Scholar 

  89. Pignata, C., P. Vajro, R. Troncone, G. Monaco, and M. Ciriaco, Immunoregulatory T subsets in chronic active viral hepatitis: Characterization by monoclonal antibodies,/. Pediatr. Gastroenterol. Nutr. 2:229–233 (1983).

    PubMed  CAS  Google Scholar 

  90. Alexander, G. J. M., M. Mondelli, N. V. Naumov, K. T. Nouri-Aria, D. Vergani, D. Lowe, A. L. W. F. Eddleston, and R. Williams, Functional characterization of peripheral blood lymphocytes in chronic HBsAg carriers, Clin. Exp. Immunol. 63:498–507 (1986).

    PubMed  CAS  Google Scholar 

  91. Rubin, R. H., W. P. Carney, R. T. Schooley, R. B. Colbin, R. C. Burton, R. A. Hoffman, W. P. Harrsen, A. B. Cosimi, P. S. Russell, and M. S. Hirsch, The effect of infection on T-lymphocyte subpopulations: A preliminary report, Int. J. Immunopharmacol. 3:307–312 (1981).

    Article  PubMed  CAS  Google Scholar 

  92. Mallucci, L. and B. Edwards, Influence of the cytoskeleton on the expression of a mouse hepatitis virus (MHV-3) in peritoneal macrophages: Acute and persistent infection, J. Gen. Virol 63:217–221 (1982).

    Article  PubMed  Google Scholar 

  93. Chisari, F. V. Regulation of lymphocyte function and viral transformation by hepatic bioregulatory molecules, Hepatology 2:97–106s (1982).

    Google Scholar 

  94. Levy, G. A., and F. V. Chisari, The immunopathogenesis of chronic HBV induced liver disease, Spnger Semin. Immunopathol. 3:439–459 (1981).

    Article  CAS  Google Scholar 

  95. Berg, P. A., N. W. Brattig, and W. Grauer, Immunoregulatory serum factors in acute and chronic hepatitis, Liver 2:275–278 (1982).

    Google Scholar 

  96. Brattig, N. W., and P. A. Berg, Serum inhibitory factors (SIF) in patients with acute and chronic hepatitis and their clinical significance, Clin. Exp. Immunol. 25:40–49 (1976).

    PubMed  CAS  Google Scholar 

  97. Sanders, G. and R. P. Perillo, Rosette inhibitory factor: T-lymphocyte subpopulation specificity and potential immunoregulatory role in hepatitis B virus infection, Hepatology 2:547–552 (1982).

    Article  PubMed  CAS  Google Scholar 

  98. Grauer, W., N. W. Brattig, H. Schomerus, G. Frosner, and P. A. Berg, Immunosup pressive serum factors in viral hepatitis. III. Prognostic relevance of rosette inhibitory factor and serum inhibitory factor in acute and chronic hepatitis, Hepatology 4:15–19 (1984).

    Article  PubMed  CAS  Google Scholar 

  99. Brattig, N. W., G. E. Schrempf-Dekker, C. W. Brockl, and P. A. Berg, Immunosuppressive serum factors in viral hepatitis. II. Further characterization of serum inhibition factor as an albumin-associated molecule, Hepatology 3:647–655 (1983).

    Article  PubMed  CAS  Google Scholar 

  100. Hill, D. A., J. H. Walsh, and R. H. Purcell, Failure to demonstrate circulating interferon during incubation period and acute stage of transfusion-associated hepatitis, Proc. Soc. Exp. Biol. Med. 136:853–856 (1971).

    PubMed  CAS  Google Scholar 

  101. Levin, S., and T. Hahn, Interferon system in acute viral hepatitis, Lancet 1:592–594 (1982).

    Article  PubMed  CAS  Google Scholar 

  102. Tolentino, P., F. Dianzani, M. Zucca, and R. Giacchino, Decreased interferon response by lymphocytes from children with chronic hepatitis, J. Infect. Dis. 132:459–461 (1975).

    Article  PubMed  CAS  Google Scholar 

  103. Yousefi, S., M. R. Escobar, and R. L. Carithers, Immune interferon induction: A measure of cellular immune deficiency in hepatitis B carriers, Hepatology 3:826 (1983) (abst.).

    Google Scholar 

  104. Pirovino, M., M. Aguet, M. Huber, J. Altorfer, and M. Schmid, Absence of detectable serum interferon in acute and chronic viral hepatitis, Hepatology 6:645–647 (1986).

    Article  PubMed  CAS  Google Scholar 

  105. Kato, Y., H. Nakgawa, K. Kobayashi, N. Hattori, and K. Hatano, Interferon production by peripheral lymphocytes in HBsAg-positive liver diseases, Hepatology 2:789–790 (1982).

    Article  PubMed  CAS  Google Scholar 

  106. Davis, G. L., J. L. Jicha, and J. H. Hoofnagle, Alpha and gamma interferon in patients with chronic type B, non-A, non-B, and delta hepatitis: Serum levels and in vitro produc tion by lymphocytes, Gastroenterology 86:1315 (1984) (abst.).

    Google Scholar 

  107. Anderson, R. E., W. Winkelstein, Jr., H. E. Blum, and G. N. Vyas, Hepatitis B virus infection in the acquired immunodeficiency syndrome (AIDS), in: Viral Hepatitis and Liver Disease (G. N. Vyas, J. L. Dienstag, and J. H. Hoofnagle, eds.), pp. 339–343, Grune &Stratton, Orlando, Florida (1984).

    Google Scholar 

  108. McDonald, M. I., J. D. Hamilton, and D. T. Durack, Hepatitis B surface antigen could harbor the infectious agent of AIDS, Lancet 2:882–884 (1983).

    Article  PubMed  CAS  Google Scholar 

  109. Ravenholt, R. T., Role of hepatitis B virus in acquired immunodeficiency syndrome, Lancet 2:885–886 (1983).

    Article  PubMed  CAS  Google Scholar 

  110. Taylor, P. E., C. E. Stevens, S. Rodriguez de Cordoba, and P. Rubinstein, Hepatitis B virus and human immunodeficiency virus: Possible interaction, in: Viral Hepatitis and Liver Disease (A.J. Zuckerman, ed.), pp. 198–200, Alan R. Liss, Inc., New York (1988).

    Google Scholar 

  111. Govindarajan, S., V. M. Edwards, M. L. Stuart, E. A. Operskalski, J. W. Mosley, and The Transfusion Safety Study Group, Influence of human immunodeficiency virus infection on expression of chronic hepatitis B and D virus infections, in: Viral Hepatitis and Liver Disease (A. J. Zuckerman ed.), pp. 201–204, Alan R. Liss, Inc., New York (1988).

    Google Scholar 

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© 1989 Plenum Press, New York

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Escobar, M.R. (1989). Immunomodulation by Hepatitis B and Related Viruses. In: Specter, S., Bendinelli, M., Friedman, H. (eds) Virus-Induced Immunosuppression. Infectious agents and pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5583-0_2

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