Abstract
Over the years, three phenomena have focused attention on members of the arenaviruses family. Soon after the discovery of lymphocytic choriomeningitis virus (LCMV), it became apparent that the virus was capable of establishing a persistent infection in its natural host, Mus musculus. (1) Persistence of virus in animals infected in utero or in the newborn period is a feature shared by all Arenaviridae and probably represents a mechanism for virus survival in nature.(2) The mechanisms responsible for this viral persistence have been extensively investigated. Second, acute disease due to LCMV in adult mice can be abrogated by treatments that immunosuppressed the host. Subsequent studies have demonstrated that much of the pathology associated with Arenaviridae-induced diseases has an immune basis. These include the acute central nervous system (CNS) disease attributed to T lymphocytes as well as renal disease in chronically infected animals attributable to immune complex formation.(3,4) Finally, arenaviruses produce severe hemorrhagic diseases in humans, an incidental host. These include Argentine hemorrhagic fever caused by Junin virus, Bolivian hemorrhagic fever caused by Machupo virus, and Lassa fever caused by Lassa virus. The virulence of these viruses in humans has hampered investigation of the pathophysiology of the diseases they produce, although considerable information is available from clinical studies and from experimental infections using avirulent mutants in susceptible laboratory animals. Despite the fact that virus modulation of host immunity could contribute to all three phenomena, there is only limited evidence that this is the case.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Traub, E., Persistence of lymphocytic choriomeningitis virus in immune animals and its relation to immunity, J. Exp. Med. 63:847–861 (1936).
Johnson, K. N., P. A. Webb, and G. Justines, Biology of Tacaribe-complex viruses, in: Lymphocytic Choriomeningitis Virus and Other Arenaviruses (F. Lehmann-Grube, ed.), pp. 241–258, Springer-Verlag, New York (1973).
Buchmeier, M. J., R. M. Welsh, F. J. Dutko, and M. B. A. Oldstone, The virology and immunobiology of lymphocytic choriomeningitis virus infection, Adv. Immunol. 30:275–331 (1980).
Lehmann-Grube, F., Portrait of viruses: Arenaviruses, Intervirol. 22:121–145 (1984).
Howard, C. R., and P. R. Young, Variation among new and old world arenaviruses, Trans. R. Inc. Trop. Med. Hyg. 78:299–306 (1984).
Wulff, H., J. V. Lange, and P. A. Webb, Interrelationships among arenaviruses measured by indirect immunofluorescence, Intervirol. 9:344–350 (1978).
Murphy, F. A., P. A. Webb, K. M. Johnson, and S. G. Whitfield, Morphological com parison of Machupo with lymphocytic choriomeningitis virus: Basis for a new taxonomic group, J. Virol. ,4:535–541 (1969).
Murphy, F. A., and S. G. Whitfield, Morphology and morphogenesis of arenaviruses, Bull. WHO 52:409–419 (1975).
Rawls, W. E., and W. C. Leung, Arenaviruses, in: Comprehensive Virology ,Vol. 14 (H. Fraenkel-Conrat and R. R. Wagner, eds.), pp. 157–192, Plenum, New York (1979).
Leung, W. C., and W. E. Rawls, Virion-associated ribosomes are not required for the replication of Pichinde virus, Virology 81:174–176 (1977).
Auperin, D., V. Romanowski, M. Galinski, and D. H. L. Bishop, Sequencing studies of Pichinde arenavirus S RNA indicate a novel coding strategy in ambisense viral S RNA, J. Virol. 52:897–908 (1984).
Buchmeier, M. J., and M. B. A. Oldstone, Protein structure of lymphocytic choriomeningitis virus: Evidence for a cell-associated precursor of the virion glycopeptides, Virology 99:111–120 (1979).
Harnish, D. G., W. C. Leung, and W. E. Rawls, Characterization of polypeptides immunoprecipitable from Pichinde virus-infected BHK-21 cells, J. Virol. 38:840–848 (1981).
Gard, G. P., A. C. Vezza, D. H. L. Bishop, and R. W. Compans, Structural proteins of Tacaribe and Tamiami virions, Virology 83:84–95 (1977).
Casals, J., Arenaviruses, in: Viral Infections of Humans ,2nd ed. (A. Evans, ed.), pp. 127–150, Plenum, New York (1984).
de Bracco, M. M. E., M. T. Rimoldi, P. M. Cossio, A. Rabinovich, J. I. Maistegui, G. Carballa, and R. M. Arana, Argentine hemorrhagic fever. Alterations of the complement system and anti-Junin-virus humoral response, N. Engl. J. Med. 299:216–220 (1978).
Hotchin, J., The biology of lymphocytic choriomeningitis infection. Virus-induced immune disease, Cold Spring Harbor Symp. Quant. Biol. 27:479–499 (1962).
Gilden, D. H., G. A. Cole, and N. Nathanson, Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers, J. Exp. Med. 135:874–889 (1972).
Doherty, P. C., and R. M. Zinkernagel, Capacity of sensitized thymus-derived lymphocytes to induce fatal lymphocytic choriomeningitis is restricted by the H-2 gene complex, J. Immunol. 114:30–33 (1975).
Allan, J. E., and P. C. Doherty, Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis, Cell. Immunol. 90:401–407 (1985).
Doyle, M. V., and M. B. A. Oldstone, Interactions between viruses and lymphocytes. I. In vivo replication of lymphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections, J. Immunol. 121:1262–1269 (1978).
Popescu, M., J. Löhler, and F. Lehmann-Grube, Infectious lymphocytes in lymphocytic choriomeningitis virus carrier mice, J. Gen. Virol. 42:481–492 (1979).
Lohler, J., and F. Lehmann-Grube, Immunopathologic alterations of lymphatic tissues of mice infected with lymphocytic choriomeningitis virus. I. Histopathologic findings, Lab. Invest. 44:193–204 (1981).
Lehmann-Grube, F., U. Assmann, C. Löliger, D. Moskophidis, and J. Löhler, Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice,J. Immunol. 134:608–615 (1985).
Byrne, J. A., and M. B. A. Oldstone, Biology of cloned cytotoxic T lymphocytes-specific for lymphocytic choriomeningitis virus. VI. Migration and activity in vivo in acute and persistent infection, J. Immunol. 136:698–704 (1986).
Webb, P. A., K. M. Johnson, C. J. Peters, and G. Justines, Behavior of Machupo and Latino viruses in calomys callosus from two geographic areas of Bolivia, in: Lymphocytic Choomeningitis Virus and Other Arenaviruses (F. Lehmann-Grube, ed.), pp. 313–322, Springer-Verlag, Berlin (1973).
Gilden, D. H., H. M. Friedman, C. O. Kyj, R. A. Roosa, and N. Nathanson, Tamiami virus-induced immunopathological disease of the central nervous system, in: Lymphocytic Choriomeningitis Virus and Other Arenaviruses (F. Lehmann-Grube, ed.), pp. 287–297, Springer-Verlag, New York (1973).
Trapido, H., and C. Sanmartin, Pichinde virus, a new virus of the Tacaribe group from Colombia, Am. J. Trop. Med. Hyg. 20:631–641 (1971).
Buchmeier, M. J., and W. E. Rawls, Variation between strains of hamsters in the lethality of Pichinde virus infections, Infect. Immun. 16:413–421 (1977).
Gee, S. R., M. A. Chan, D. A. Clark, and W. E. Rawls, Role of natural killer cells in Pichinde virus infection of Syrian hamsters, Infect. Immun. 31:919–928 (1981).
Jahrling, P. B., R. A. Hesse, J. B. Rhoderick, M. A. Elwell, and J. B. Moe, Pathogenesis of a Pichinde virus strain adapted to produce lethal infection in guinea pigs, Infect. Immun. 32:872–880 (1981).
Murphy, F. A., M. J. Buchmeier, and W. E. Rawls, The reticuloendothelium as the target in a virus infection: Pichinde virus pathogenesis in two strains of hamsters, Lab. Invest. 37:502–515 (1977).
Weissenbacher, M. C., L. B. De Guerrero, and M. C. Boxaca, Experimental biology and pathogenesis of Junin virus infection in animals and man, Bull. WHO 52:507–515 (1975).
Walker, D. H., H. Wulff, J. V. Lange, and F. A. Murphy, Comparative pathology of Lassa virus infection in monkeys, guinea-pigs and Mastomys natalensis, Bull. WHO 52:523–534 (1975).
Borden, E. C., and N. Nathanson, Tacaribe virus infection of the mouse: An immunopathologic disease model, Lab. Invest. 30:465–473 (1974).
Barrios, H. A., S. N. Rondinone, J. L. Blejer, O. A. Giovaniello, and N. R. Nota, Development of specific immune response in mice infected with Junin virus, Acta Virol. (Praha) 26:156–164 (1982).
Weissenbacher, M. C., M. A. Calello, C. J. Quintans, H. Panisse, N. M. Woyskowski, and V. H. Zanndi, Junin virus infection in genetically athymic mice, Intervirology 19:1–5 (1983).
Besuschio, S. C., M. C. Weissenbacher, and G. A. Schmunis, Different histopathological response to arenavirus infection in thymectomized mice, Arch. Ges. Virusforsch. 40:21–28 (1973).
Laguens, R. M., M. M. Avila, S. R. Samoilovich, M. C. Weissenbacher and R. P. Laguens, Pathogenicity of an attenuated strain (XJCl3) of Junin virus. Morphological and virological studies in experimentally infected guinea pigs, Intervirology 20:195–201 (1983).
Murphy, F. A., W. Winn, D. H. Walker, M. R. Flemister, and S. G. Whitfield, Early lymphoreticular viral tropism and antigen persistence. Tamiami virus infection in the cotton rat, Lab. Invest. 34:125–140 (1976).
Carballal, G., M. Rodriguez, M. J. Frigerio, and C. Vasquez, Junin virus infection of guinea-pigs: Electron microscope studies of peripheral blood and bone marrow, J. Infect. Dis. 135:367–373 (1977).
Laguens, M., J. G. Chambo, and R. P. Laguens, In vivo replication of pathogenic and attenuated strains of Junin virus in different cell populations of lymphatic tissue, Infect. Immun. 41:1279–1283 (1983).
Mims, C. A., and S. Wainwright, The immunodepressive action of lymphocytic choriomeningitis virus in mice, J. Immunol. 101:717–724 (1968).
Bro-Jørgensen, K., F. Güttler, P. N. Jørgensen, and M. Volkert, T lymphocyte function as the principal target of lymphocytic choriomeningitis virus-induced immunosuppression, Infect. Immun. 11:622–629 (1975).
Bro-Jørgensen, K., and M. Volkert, Defects in the immune system of mice infected with lymphocytic choriomeningitis virus, Infect. Immun. 9:605–614 (1974).
Oldstone, M. B. A., A. Tishon, J. M. Chiller, W. O. Weigle, and F. J. Dixon, Effect of chronic viral infection on the immune system. 1. Comparison of the immune responsiveness of mice chronically infected with LCM virus with that of non-infected mice, J. Immunol 110:1268–1278 (1973).
Haas, V. H., Some relationships between lymphocytic choriomeningitis (LCM) virus and mice, J. Infect. Dis. 94:187–198 (1954).
Traub, E., Observations on immunological tolerance and “immunity” in mice infected congenitally with the virus of lymphocytic choriomeningitis, Arch. Ges. Virusforsch. 10:303–314 (1961).
Parodi, A. S., N. R. Nota, L. B. deGuerrero, M. J. Frigerio, M. Weissenbacher, and E. Rey, Inhibition of immune response in experimental hemorrhagic fever (Junin virus), Acta Virol. (Praha) 11:120–125 (1967).
Kimming, W., and F. Lehmann-Grube, The immune response of the mouse to lymphocytic choriomeningitis virus. I. Circulating antibodies, J. Gen. Virol. 45:703–710 (1979).
Oldstone, M. B. A., and F. J. Dixon, Lymphocytic choriomeningitis; production of antibody by “tolerant” infected mice, Science 158:1193–1195 (1967).
Hotchin, J., L. Benson and E. Sikora, The detection of neutralizing antibody to lymphocytic choriomeningitis virus in mice, J. Immunol. 102:1128–1135 (1969).
Thomsen, A. R., M. Volkert and O. Marker, Different isotype profiles of virus-specific antibodies in acute and persistent lymphocytic choriomeningitis virus infection in mice, Immunology 55:213–223 (1985).
Moskophidis, D., and F. Lehmann-Grube, The immune response of the mouse to lymphocytic choriomeningitis virus. IV. Enumeration of antibody-producing cells in spleens during acute and persistent infection, J. Immunol. 133:3366–3370 (1984).
Lehmann-Grube, F., I. Niemeyer, and J. Lohler, Lymphocytic choriomeningitis of the mouse. IV. Depression of the allograft reaction, Med. Microbiol. Immunol. 158:16–25 (1972).
Güttler, F., K. Bro-Jørgensen, P. N. Jørgensen, Transient impaired cell-mediated tumor immunity after acute infection with lymphocytic choriomeningitis virus, Scand. J. Immu nol. 4:327–336 (1975).
Jacobs, R. P., and G. A. Cole, Lymphocytic choriomeningitis virus-induced immunosuppression: A virus-induced macrophage defect, J. Immunol. 117:1004–1009 (1976).
Wilson, J. D., H. E. Webb, N. M. Molomut, and M. Padnos, Depression of PHA response in patients during therapeutic infection with MP virus, Interirology 2:41–47 (1973/ 1974).
Holterman, O. A., and J. A. Majde, An apparent histoincompatibility between mice chronically infected with LCMV and their uninfected syngeneic counterparts, Transplantation 11:20–29 (1971).
Carballal, G., J. R. Oubina, S. N. Rondinone, B. Eisner, and M. J. Frigerio, Cell-mediated immunity and lymphocyte populations in experimental Argentine hemorrhagic fever (Junin virus), Infect. Immun. 34:323–327 (1981).
Tosolini, F. A., and C. A. Mims, Effect of murine and viral strain on the pathogenesis of lymphocytic choriomeningitis infection and a study of footpad responses, J. Infect. Dis. 123:134–144 (1971).
Zinkernagel, R. M., and P. C. Doherty, MHC-restricted cytotoxic T cells: Studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness, Adv. Immunol. 27:51 –177 (1979).
Walker, C. M., W. E. Rawls, and K. L. Rosenthal, Generation of memory cell-mediated immune responses after secondary infection of mice with Pichinde virus, /. Immunol. 132:469–474 (1984).
Barrios, H. A., S. N. Giovanniello, S. N. Rondinone, O. E. Competella, and N. R. Nota, Passive transfer protection against Junin virus in cyclophosphamide-suppressed mice, Acta Virol. (Praha) 28:343 (1984).
Chan, M., D. Clark, and W. E. Rawls, Pichinde virus-specific cell-associated suppression of primary footpad swelling in an inbred strain of Syrian hamsters, J. Immunol. 130:925–931 (1983).
Cole, G. A., R. A. Prendergast, and C. S. Henney, In vitro correlates of LCM virus-induced immune response, in: Lymphocytic Choriomeningitis Virus and Other Arenaviruses (F. Lehmann-Grube, ed.), pp. 61–71, Springer-Verlag, Berlin (1973).
Marker, O., and M. Volkert, In vitro measurement of the time course of cellular immunity to LCM virus in mice, in: Lymphocytic Choriomeningitis Virus and Other Arenaviruses (F. Lehmann-Grube, ed.), pp. 207–216, Springer-Verlag, Berlin (1973).
Volkert, M., K. Bro-Jørgensen, O. Marker, B. Rubin, and L. Trier, The activity of T and B lymphocytes in immunity and tolerance to the lymphocytic choriomeningitis virus in mice, Immunology 29:455–464 (1975).
Cihak, J., and F. Lehmann-Grube, Immunological tolerance to lymphocytic choriomeningitis virus in neonatally infected virus carrier mice: evidence supporting a clonal inactivation mechanism, Immunology 34:265–275 (1978).
Popescu, M., and D. H. Ostrow, Multiplication of lymphocytic choriomeningitis virus in thymocytes during its persistence in mice, J. Gen Virol. 61:293–298 (1982).
Zinkernagel, R. M., and P. C. Doherty, Indications of active suppression in mouse carriers of lymphocytic choriomeningitis virus, in: Immunological Tolerance (D. H. Katz and B. Benacerraf, eds.), pp. 403–411, Academic, New York (1974).
Dunlop, M. B. C., and R. V. Blanden, Mechanisms of suppression of cytotoxic T-cell responses in murine lymphocytic choriomeningitis virus infection, J. Exp. Med. 145:1131 –1143 (1977).
Ahmed, R., A. Salmi, L. D. Butler, J. M. Chiller, and M. B. A. Oldstone, Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte responses and viral persistence, J. Exp. Med. 60:521–540 (1984).
Bro-Jørgensen, K., and S. Knudtzon, Changes in hemopoiesis during the course of acute LCM virus infection in mice, Blood 49:47–57 (1977).
Hanaoka, M., S. Suzuki, and J. Hotchin, Thymus-dependent lymphocytes: Destruction by lymphocytic choriomeningitis virus, Science 163:1216–1219 (1969).
Thomas, A. R., K. Bro-Jørgensen, and B. L. Jensen, Lymphocytic choriomeningitis virus-induced immunosuppression: Evidence for viral interference with T-cell maturation, Infect. Immun. 37:981–986 (1982).
Bro-Jørgensen, K., and M. Volkert, Haemopoietic defects in mice infected with lymphocytic choriomeningitis virus. 1. The enhanced x-ray sensitivity of virus infected mice, Acta Pathol. Microbiol. Scand. B 80:845–852 (1972).
Bro-Jørgensen, K., and M. Volkert, Haemopoietic defects in mice infected with lymphocytic choriomeningitis virus. 2. The viral effect upon the function of colony-forming stem cells, Acta Pathol. Microbiol. Scand. B 80:853–862 (1972).
Schwartz, R., J. Löhler, and F. Lehmann-Grube, Infection of cultivated mouse peritoneal macrophages with lymphocytic choriomeningitis virus, J. Gen. Virol. 39:565–570 (1978).
Yarborough, D. J., O. T. Meyer, A. M. Dannenberg, Jr., and B. Pearson, Histochemistry of macrophage hydrolases. III. Studies on ß-galactosidase, ß-glucuronidase and aminopeptidases with inodyl and naphthyl substrates, J. Reticuloendothel. Soc. 4:390–408 (1967).
Allison, A., Lysosomes in virus-infected cells, in: Perspectives in Virology ,Vol. V (V. M. Pollard, ed.), pp. 29–62, Academic, New York (1967).
Gledhill, A. W., D. L. J. Bilbey, and J. S. F. Niven, Effect of certain murine pathogens on phagocytic activity, Br. J. Pathol. 46:433–442 (1965).
Bro-Jørgensen, K., The interplay between lymphocytic choriomeningitis virus, immune function and hemopoiesis in mice, Adv. Viral Res. 22:327–369 (1978).
Friedlander, A. M., P. B. Jahrling, P. Merrill, and S. Tobery, Inhibition of mouse peritoneal macrophage DNA synthesis by infection with the arenavirus Pichinde, Infect. Immun. 43:283–288 (1984).
Gonzalez, P. H., J. S. Lampuri, C. E. Coto, and R. P. Laguens, In vitro infection of murine macrophages with Junin virus, Infect. Immun. 35:356–358 (1982).
Welsh, R. M., Jr., Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction, J. Exp. Med. 148:163–181 (1978).
Gee, S. R., D. A. Clark, and W. E. Rawls, Differences between Syrian hamsters strains in natural killer cell activity induced by infection with Pichinde virus, J. Immunol. 123:2618–2626 (1979).
Welsh, R. M., and R. Kiessling, Natural killer cell response to lymphocytic choriomeningitis virus in beige mice, Scand. J. Immunol. 11:363–367 (1980).
Bukowski, J. F., B. A. Woda, S. Habu, K. Okumura, and R. M. Welsh, Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo, J. Immunol. 131:1531–1538 (1983).
Silberman, S. L., R. P. Jacobs, and G. A. Cole, Mechanisms of hemopoietic and immunological dysfunction induced by lymphocytic choriomeningitis virus, Infect. Immun. 19:533–539 (1978).
Lehmann-Grube, F., F. Tijerina, W. Zeller, U. C. Chaturvedi, and J. Löhler, Age-dependent susceptibility of murine T lymphocytes to lymphocytic choriomeningitis virus, J. Gen. Virol. 64:1157–1166 (1983).
Merigan, T. C., M. B. A. Oldstone, and R. M. Welsh, Interferon production during lymphocytic choriomeningitis virus infection of nude and normal mice, Nature (Lond.) 268:67–68 (1977).
Kiessling, R., P. S. Hochman, O. Haller, G. M. Shearer, H. Wigzell, and G. Cudkowicz, Evidence for a similar or common mechanism for natural killer cell activity and resistance to haematopoietic grafts, Eur. J. Immunol. 7:655–663 (1977).
Riccardi, C., A. Santoni, T. Barlozzari, and R. B. Herberman, In vivo reactivity of mouse natural killer (NK) cells against normal bone marrow cells, Cell. Immunol. 60:136–143 (1981).
deMaeyer, E., Interferon and delayed-type hypersensitivity to viral antigen, J. Infect. Dis. 133:A63–A65 (1976).
Fink, P. J., I. L. Weissman, and M. J. Bevan, Haplotype-specific suppression of cytotoxic T cell induction by antigen inappropriately presented on T cells, J. Exp. Med. 157:141–154 (1983).
Hoffenbach, A., P. H. Lagrange, and M. A. Bach, Influence of dose and route of Mycobacterium lepraemurìum inoculation on the production of interleukin 1 and interleukin 2 in C57 B1/6 mice, Infect. Immun. 44:665–671 (1984).
Anderson, J., J. A. Byrne, R. Schreiber, S. Patterson, and M. B. A. Oldstone, Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: Clearance of virus and in vitro properties, J. Virol. 53:552–560 (1985).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Wright, K.E., Rawls, W.E. (1989). Arenaviruses. In: Specter, S., Bendinelli, M., Friedman, H. (eds) Virus-Induced Immunosuppression. Infectious agents and pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5583-0_13
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5583-0_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5585-4
Online ISBN: 978-1-4684-5583-0
eBook Packages: Springer Book Archive