Abstract
Many early investigations on the in vivo fate of intravenously injected liposomes have pointed to the liver as the major organ responsible for elimination from the circulatory system. For several years now we have made detailed studies on the participation of various cell types of the liver, mainly macrophages and hepatocytes, in the hepatic uptake and processing of liposomes, both in vivo and in vitro.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Connor, J., and Huang, L., 1985, Efficient cytoplasmic delivery of a fluorescent dye by pH-sensitive immunoliposomes, J.Cell Biol., 101:582.
Daemen, T., Veninga, A., Roerdink, F. H., and Scherphof, G. L., 1988, Tumor cytotoxicity of macrophages induced by uptake of liposome-encapsulated immunomodulators with special reference to Kupffer cells, in: “Liposomes as Drug Carriers: Trends and Progress,” G. Gregoriadis, ed., John Wiley & Sons Ltd.
Derksen, J. T. P., Morselt, H. W. M., and Scherphof, G. L., 1987, Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages, Biochim. Biophys.Acta., 931:33.
Dijkstra, J., Van Galen, W.J. M., Hulstaert, C. E., Kalicharan, D., Roerdink, F. H., and Scherphof, G. L., 1984a, Interaction of liposomes with Kupffer cells in vitro, Exp.Cell Res., 150:161.
Dijkstra, J., Van Galen, M., and Scherphof, G., 1984b, Effects of ammonium chloride and chloroquine on endocytic uptake of liposomes by Kupffer cells in vitro, Biochim.Biophys.Acta., 804:58.
Dijkstra, J., Van Galen, M., Regts, J., and Scherphof, G., 1985a) Uptake and processing of liposomal phospholipids by Kupffer cells in vitro, Eur.J.Biochem., 148:391.
Dijkstra, J., Van Galen, M., and Scherphof, G., 1985b, Influence of liposome charge on the assoication of liposomes with Kupffer cells in vitro. Effects of divalent cation and competition with latex particles, Biochim.Biophys.Acta 813:287.
Dijkstra, J., Van Galen, M., and Scherphof, G., 1985c, Effects of (dihydro)cytochalasin B, colchicin, monensin and trifluoperazine on uptake and processing of liposomes by Kupffer cells in culture, Biochim.Biophys.Acta 845:34.
Ellens, H., Mayhew, E., and Rustum, Y. M., 1982, Reversible depression of the reticuloendothelial system by liposomes, Biochim.Biophys.Acta. 714:479.
Fidler, I. J., 1980, Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines, Science 208:1469.
Fidler, I. J., Sone, S., Fogler, W. E., and Barnes, Z. L., 1981, Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyldipeptide, Proc.Natl.Acad.Sci.USA 78:1680.
Freise, J., Müller, W. H., and Magerstedt, P., 1981, Uptake of liposomes and sheep red blood cells by the liver and spleen of rats with normal and decreased function of the reticuloendothelial system, Res.Exp.Med., 178:263.
Hsu, M. J., and Juliano, R. L., 1982, Interactions of liposomes with the reticuloendothelial system. II. Non-specific and receptor-mediated uptake of liposomes by mouse peritoneal macrophages, Biochim. Biophys.Acta., 720:411.
Husztik, E., Lázár, G., and Párducz, A., 1980, Electron microscopic study of Kupffer cell phagocytosis blockade induced by Gadolinium chloride, Br.J.Exp.Pathol., 61:624.
Kao, Y. J., and Juliano, R. L., 1981, Interactions of liposomes with the reticuloendothelial system. Effects of reticuloendothelial blockade on the clearance of large unilamellar vesicles, Biochim.Biophys.Acta 677, 453.
Kooistra, T., Duursma, A. M., Bouma, J. W. M., and Gruber, M., 1979, Endo-cytosis and breakdown of ribonuclease oligomers by sinusoidal rat liver cells in vivo. I. Effect of size, Biochim.Biophys.Acta 587:282.
Kuipers, F., Spanjer, H. H., Havinga, R., Scherphof, G.L., and Vonk, R. J., 1986, Lipoproteins and liposomes as in vivo cholesterol vehicles in the rat: Preferential use of cholesterol carried by small unilamellar liposomes for the formation of muricholic acids, Biochim. Biophys.Acta, 987:559.
Kuipers, F., Derksen, J. T. P., Gerding, A., Scherphof, G. L., and Vonk, R. J., 1987, Biliary lipid secretion in the rat. The uncoupling of biliary cholesterol and phospholipid secretion from bile acid secretion by sulfated glycolithocholic acid, Biochim.Biophys.Acta. 922:136.
Mauk, M. R., Gamble, R. C., and Baldeschwieler, J. D., 1980, Stability of lipid vesicles in tissues of the mouse: a gamma-ray perturbed angular correlation study, Science 207:309.
Pagano, R. E., and Weinstein, J. W., 1978, Interactions of liposomes with mammalian cells, Ann.Rev.Biophys.Bioeng., 7:435.
Patel, H. M., Tüzel, N. S., and Ryman, B. E., 1983, Inhibitory effect of cholestrol on the uptake of liposomes by liver and spleen, Biochim. Bopphys.Acta., 761:142.
Poste, G., Kirsh, R., Fofler, W. E., and Fidler, I. J., 1979, Activation of tumoricidal properties in mouse macrophages by lymphokines encapsulated in liposomes, Cancer Res., 39:881.
Poste, G., Bucana, C., Raz, A., Bugelski, P., Kirsh, R., and Fidler, I. J., 1982, Analysis of the fate of systemically administered liposomes and implication for their use in drug delivery, Cancer Res., 42:1412.
Rahman, Y. E., Cerny, E. A., Patel, H. R., Lan, E. H., and Wright, B. J., 1982, Differential uptake of liposomes varying in size and lipid composition by parenchymal and Kupffer cells of mouse liver, Life Sci., 31:2061.
Raz, A., Bucana, C., Fogler, W. E., Poste, G., and Fidler, I. J., 1981, Biochemical, morphological and ultrastructural studies on the uptake of liposomes by murine macrophages, Cancer Res., 41:487.
Roerdink, F., Dijkstra, J., Hartman, G., Bolscher, B., and Scherphof, G., 1981, The involvement of parenchymal, Kupffer and endothelial liver cells in hepatic uptake of intravenously injected liposomes. Effects of lanthanum and gadolinium salts, Biochim.Biophys.Acta. 677:79.
Roerdink, F. H., Regts, J., Van Leeuwen, B., and Scherphof, G. L., 1984, Intrahepatic uptake and processing of intravenously injected small unilamellar vesicles in rats, Biochim.Biophys.Acta., 770:195.
Scherphof, G., Roerdink, F., Dijkstra, J., Ellens, H., De Zanger, R., and Wisse, E., 1983, Uptake of liposomes by rat and mouse hepatocytes and Kupffer cells, Biol.Cell 47:47.
Senior, J., and Gregoriadis, G., 1982, Is the half-life of circulating liposomes determined by changes in their permeability? FEBS Lett. 145:109.
Senior, J., Crawley, J. C. W., and Gregoriadis, G., 1985, Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection, Biochim.Biophys.Acta 839:1.
Souhami, R. L., Patel, H. M., and Ryman, B. E., 1981, The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes, Biochim.Biophys.Acta., 674:354.
Spanjer, H., and Scherphof, G., 1983, Targeting of lactosylceramide containing liposomes to hepatocytes in vivo, Biochim.Biophys.Acta 734:40.
Spanjer, H. H., Van Galen, M., Roerdink, F. H., Regts, J., and Scherphof, G. L., 1986, Intrahepatic distribution of small unilamellar liposomes as a function of liposomal lipid composition, Biochim. Biophys.Acta., 863:224.
Szoka, F. C., Magnusson, K.-C., Wojcieszyn, J., Hou, Y., Derzko, Z., and Jacobson, K., 1981, Use of lectins and polyethylene glycol for fusion of glycolipid-containing liposomes with eukaryotic cells, Proc.Natl.Acad.Sci.USA., 78:1685.
Wilschut, J. C., 1982, Preparation and properties of phospholipid vesicles, in; “Liposome Methodology,” L.D. Leserman and J. Barbet, eds., Inserm, Paris, Vol. 107, pp. 9–24.
Wisse, E., Gregoriadis, G., and Daems, W.Th., (1976), Electron microscopic cytochemical localization of intravenously injected liposome-encapsulated horse radish peroxidase in rat liver cells, in: The Reticuloendothelial System in Health and Disease, Plenum Press, New York, 237–245.
Wisse, E., De Zanger, R., and Jacobs, R., 1982, Lobular gradients in endothelial fenestrae and sinusoidal diameter favor centrolobular exchange processes: a scanning EM study in: Sinusoidal Liver Cells, D. L. Knook and E. Wisse, eds., Elsevier Biomedical Press, Amsterdam, 61–67.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Scherphof, G.L., Daemen, T., Derksen, H., Lázár, G., Spanjer, H.H., Roerdink, F.H. (1988). In Vivo Uptake and Processing of Liposomes by Parenchymal and Non-Parenchymal Liver Cells; Application to Immunotherapeutic Treatment of Hepatic Metastases. In: Gregoriadis, G., Poste, G. (eds) Targeting of Drugs. NATO ASI Series, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5574-8_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5574-8_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5576-2
Online ISBN: 978-1-4684-5574-8
eBook Packages: Springer Book Archive