Haemopoietic Regulation and the Role of the Macrophage in Erythropoietic Gene Expression

  • Ivan N. Rich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)


The macrophage is considered as an “active” component of the haemopoietic cellular microenvironment with respect to erythropoietin (epo) production during embryonic, foetal and adult erythropoiesis. Emphasis is placed on steady-state rather than pathophysiological conditions. In addition, the signals capable of affecting the functional capacity of the macrophage with regard to colony stimulating factor and epo production are also taken into account. Evidence is given demonstrating that a subpopulation of resident macrophages in vitro and in the mouse bone marrow, under normal conditions, can express the epo gene. These results indicate that erythropoiesis can be regulated by short-range or cell-to-cell interactions within the bone marrow.


Foetal Liver Mouse Bone Marrow Cellular Microenvironment Erythropoietin Production Hemopoietic Growth Factor 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ivan N. Rich
    • 1
  1. 1.Department of Transfusion MedicineUniversity of UlmUlmGermany

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