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Molecular Biology of Hemopoiesis pp 319–328Cite as

Production of Erythropoietin by an Established Human Renal Carcinoma Cell Line: In Vitro and In Vivo Studies

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 34))

Abstract

The inverse relationship between tissue oxygenation and circulating erythropoietin levels has been well documented in clinical and in vivo experimental studies1. Although a considerable body of information exists on the correlation between erythropoietin production in vivo and such parameters involved in oxygen supply as hemoglobin concentration, red cell mass, ambient pO2, and hemoglobin-oxygen affinity, little information exists on regulation of erythropoietin synthesis and secretion at the cellular level.

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Author information

Authors and Affiliations

  1. The Liver Unit, Department of Medicine A, Hadassah University Hospital, 91120, Jerusalem, Israel

    Daniel Shouval

  2. Division of Hematology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Judith B. Sherwood

Authors
  1. Daniel Shouval
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  2. Judith B. Sherwood
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Editor information

Editors and Affiliations

  1. Veterans Administration Medical Center, University of Mississippi, Jackson, Mississippi, USA

    Mehdi Tavassoli

  2. Veterans Administration Medical Center, University of Nevada, Reno, Nevada, USA

    Esmail D. Zanjani

  3. New York Medical College, Valhalla, New York, USA

    Joao L. Ascensao  & Nader G. Abraham  & 

  4. Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Alan S. Levine

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© 1988 Plenum Press, New York

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Shouval, D., Sherwood, J.B. (1988). Production of Erythropoietin by an Established Human Renal Carcinoma Cell Line: In Vitro and In Vivo Studies. In: Tavassoli, M., Zanjani, E.D., Ascensao, J.L., Abraham, N.G., Levine, A.S. (eds) Molecular Biology of Hemopoiesis. Advances in Experimental Medicine and Biology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5571-7_35

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  • DOI: https://doi.org/10.1007/978-1-4684-5571-7_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5573-1

  • Online ISBN: 978-1-4684-5571-7

  • eBook Packages: Springer Book Archive

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