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Factors Regulating Megakaryocytopoiesis and Platelet Formation

  • Chapter
Molecular Biology of Hemopoiesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 34))

Abstract

During the past two decades evidence has accumulated which indicates that platelet production from megakaryocytes or megakaryocyte precursor cells is regulated by humoral factors1–4. Many factors which are suspected to be involved in megakaryocytopoiesis and/or platelet formation have been reported (Tables I and II). Some of these factors have been purified to homogeneity or molecularly cloned, and their biochemical Natures and biological activities on hematopoietic cells, including cells of the megakaryocyte lineage, have been investigated. Among these factors are megakaryocyte colony-stimulating factor (Meg- CSF)5–7, thrombocytopoiesis-stimulating factor or thrombopoietin (Tpo)8–10, interleukin 3 (IL- 3)11,12 multi-colony-stimulating factor (multi-CSF)13–17, granulocyte/macrophage colony-stimulating factor (GM-CSF)12,18,19 and erythropoietin (Epo)5,20,21.

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Author information

Authors and Affiliations

  1. Hipple Cancer Research Center, Daytorn, Ohio, USA

    Tsutomu Abe, J. Peter Fuhrer, Marvin D. Bregman & Martin J. Murphy Jr.

  2. Research Institute for Nuclear Medicine and Biology, Hiroshima University, Hiroshima, Japan

    Atsushi Kuramoto

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  1. Tsutomu Abe
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  2. J. Peter Fuhrer
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  3. Marvin D. Bregman
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  4. Atsushi Kuramoto
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  5. Martin J. Murphy Jr.
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Editor information

Editors and Affiliations

  1. Veterans Administration Medical Center, University of Mississippi, Jackson, Mississippi, USA

    Mehdi Tavassoli

  2. Veterans Administration Medical Center, University of Nevada, Reno, Nevada, USA

    Esmail D. Zanjani

  3. New York Medical College, Valhalla, New York, USA

    Joao L. Ascensao  & Nader G. Abraham  & 

  4. Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Alan S. Levine

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© 1988 Plenum Press, New York

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Abe, T., Fuhrer, J.P., Bregman, M.D., Kuramoto, A., Murphy, M.J. (1988). Factors Regulating Megakaryocytopoiesis and Platelet Formation. In: Tavassoli, M., Zanjani, E.D., Ascensao, J.L., Abraham, N.G., Levine, A.S. (eds) Molecular Biology of Hemopoiesis. Advances in Experimental Medicine and Biology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5571-7_21

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  • DOI: https://doi.org/10.1007/978-1-4684-5571-7_21

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