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Exogenous and Endogenous Regulations of Human Megakaryocytopoiesis

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Book cover Molecular Biology of Hemopoiesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 34))

Abstract

Megakaryocytopoiesis may be viewed as a developmental continuum which begins when an undifferentiated hematopoietic stem cell commits to maturation within this lineage (for recent review see ref.#l) The process of commitment results in the generation of megakaryocyte progenitor cells (CFU-Meg). When appropriately stimulated, CFU-Meg are capable of intense proliferative activity which determines the numbers of megakaryocytes which will ultimately populate the bone marrow. As proliferative activity declines, CFU-Meg progeny mature into precursor cells which terminally differentiate into polyploid megakaryocytes capable of releasing several thousand platelets each into the circulation.

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References

  1. Gewirtz, A.M. 1986. Human megakaryocytopoiesis. Seminars in Hematology 23: 27–42.

    PubMed  CAS  Google Scholar 

  2. Hoffman, R., H.H. Yank, E. Bruno, and J. Straneva. 1985. Purification and partial characterization of a megakaryocyte colony stimulation factor from human plasma. J. Clin. Invest. 75: 1174–1182.

    Article  PubMed  CAS  Google Scholar 

  3. Kaushansky, K., P. O’Hara, K. Berner, G.M. Segal, F.S. Hagen, and J. W. Adamson. 1986. Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte- macrophage colony-stimulating activity. Proc. Natl. Acad. Sci. USA 83: 3101–3105.

    Article  PubMed  CAS  Google Scholar 

  4. Leary, A.G., Y.C. Yang, S.C. Clark, J.C. Gasson, D.W., Golde, and M. Ogawa. 1987. Recombinant Gibbon Interleukin-3 supports formation of human multilineage colonies and blast cell colonies in culture: Comparison with recombinant human granulocyte-macrophage colony stimulating factor. Blood 70: 1343–1348.

    PubMed  CAS  Google Scholar 

  5. McDonald, T.P., M. Cottrell, and R.D. Clift. 1985. Studies on the purification of thrombopoietin from kidney cell culture medium. J. Lab. Clin. Med. 106: 162–174.

    PubMed  CAS  Google Scholar 

  6. Hill, R., and J. Levin. 1986. Partial Purification of Thrombopoietin using lectin chromatography. Exp. Hematol. 14: 752–759.

    PubMed  CAS  Google Scholar 

  7. Greenberg, S.M., D.J. Kuter, and R.D. Rosenberg. 1987. In vitro stimulation of megakaryocyte maturation by megakaryocyte stimulatory factor. J. Biol. Chem. 262: 3269–3277.

    PubMed  CAS  Google Scholar 

  8. Tayrien, G. and R.D. Rosenberg. 1987. Purification and properties of a megakaryocyte stimulatory factor present both in the serum — free conditioned medium of human embryonic kidney cells and in thrombocytopenic plasma. J. Biol. Chem. 262: 3262–3268.

    PubMed  CAS  Google Scholar 

  9. Ishibashi, T., S.A. Kozial, and S.A. Burstein. 1987. Human recombinant erythropoietin promotes differentiation of murine megakaryocytes in vitro. J. Clin. Invest. 79: 286–289.

    Article  PubMed  CAS  Google Scholar 

  10. Nagasawa, T., T. Sakuri, H. Kashiwagi, and T. Abe. 1986. Cell-mediated amegakaryocytic thrombocytopenia associated with systemic lupus erythematosus. Blood 67: 479–483.

    PubMed  CAS  Google Scholar 

  11. Gewirtz, A.M., M.C. Sacchitti, R. Bien, and W.E. Barry. 1986. Cell mediated suppression of megakaryocytopoiesis in Acquired Amegakaryocytic Thrombocytopenic Purpura. Blood 68: 619–626.

    PubMed  CAS  Google Scholar 

  12. Vainchenker, W., J. Chapman, J.F. Deschamps, G. Vinci, J. Bouguet, M. Titeux, and J. Breton-Gorius. 1982. Normal human serum contains a factor(s) capable of inhibiting megakaryocyte colony formation. Exp. Hematol. 10: 650–660.

    PubMed  CAS  Google Scholar 

  13. Messner, H.A., N. Jamal, and C. Izaquirre. 1982. The growth of large megakaryocyte colonies from human bone marrow. J. Cell Physiol. [Suppl.] 1: 45–51.

    Article  CAS  Google Scholar 

  14. Kimura, H. S. A. Burstein, D. Thorning, J.S. Powell, L.A. Harker, P.J. Failkow, and J. W. Adamson. 1984. Human megakaryocyte progenitors (CFU-M) assayed in methylcellulose: Physical characteristics and requirements for growth. J. Cell Physiol. 118: 87–94.

    Article  PubMed  CAS  Google Scholar 

  15. Ishibashi, T., S.L. Miller, and S.A. Burstein. 1987. Type B transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro. Blood 69: 1737–1741.

    PubMed  CAS  Google Scholar 

  16. Dessypris, E.N., J.H. Gleaton, S.T. Sawyer, and O.L. Armstrong. 1987. Suppression of maturation of megakaryocyte colony forming unit in vitro by a platelet-released glycoprotein. J. Cell. Physiol. 130: 361–368.

    Article  PubMed  CAS  Google Scholar 

  17. Gewirtz, A., M. Keefer, K. Doshi, A. Annamali, H.C. Chiu, and R.W. Colman. 1986. Biology of Human Megakaryocyte Factor V. Blood 67: 1639–1648.

    PubMed  CAS  Google Scholar 

  18. Gewirtz, A. 1987. Recent methodologic advances in the study of human megakaryocyte development and function. In Modern methods of pharmacology: Methods for studying platelet and megakaryocytes (R.W. Colman and B.J. Smith, eds.) pp 1–18, Alan R. Liss, Inc., New York.

    Google Scholar 

  19. Gewirtz, A.M., E. Bruno, J. Elwell, and R. Hoffman. 1983. In vitro studies of megakaryocytopoiesis in thrombocytotic disorders of man. Blood 61: 384–389.

    PubMed  CAS  Google Scholar 

  20. Gewirtz, A.M., M.K. Sacchetti, R. Bien, and W. Barry. 1986. Cell mediated suppression of megakaryocytopoiesis in acquired amegakaryocytic thrombocytopenic purpura. Blood 68: 619–626.

    PubMed  CAS  Google Scholar 

  21. Gewirtz, A.M., W.Y. Xu, and K.F. Mangan. 1987. Role of natural killer cells, in comparison with T lymphocytes and monocytes, in the regulation of normal human megakaryocytopoiesis in vitro. J. Immunol. 139: 2915–2925.

    PubMed  CAS  Google Scholar 

  22. Mangan, K.F., M. Hartnett, S.A. Matis, A. Winkelstein, and T. Abo. 1984. Natural killer cells suppress human erythroid stem cell proliferation in vitro. Blood 63: 260.

    PubMed  CAS  Google Scholar 

  23. Timonen, T., C. W. Reynolds, J.R. Ortaldo, and R.B. Herberman. 1982. Isolation of human and rat natural killer cells. J. Immunol. Methods. 51: 269.

    Article  PubMed  CAS  Google Scholar 

  24. Indiveri, F., B.S. Wilson, M.A. Pellegrino, and S. Ferrone. 1979. Detection of human histocompatibility (HLA) antigens with an indirect rosette microassay. J. Immunol. Methods. 29: 101.

    Article  PubMed  CAS  Google Scholar 

  25. Weiner, W.S., C. Bianco, V. Nussenzweig. 1973. Enhanced binding of neuraminidase treated sheep erythrocytes to human T lymphocytes. Blood 42: 939.

    PubMed  CAS  Google Scholar 

  26. Rucinski, B., S. Niewwiarowski, P. James, D.A. Walz, and A. Budzynski. 1979. Antiheparin proteins secreted by human platelets. Purification, characterization, and radioimmunoassay. Blood 53: 47–62.

    PubMed  CAS  Google Scholar 

  27. Neland, A.C., D. Catovsky, D. Linch, J.C. Cawley, P. Beverley, J.F. San Miguel, E.C. Gordon-Smith, T.E. Blecher, S. Shahriari, and S. Varadi. 1984. Chronic T cell lymphocytosis: a review of 21 cases. Br. J. Haematol. 58: 433.

    Article  Google Scholar 

  28. Reynolds, C.W., and K.A. Foon. 1984. T-lymphoproliferative disease and related disorders in humans and experimental animals: A review of the clinical, cellular, and functional characteristics. Blood 64: 1146.

    PubMed  CAS  Google Scholar 

  29. Levitt, L., T.J. Kipps, E.G. Engleman, and P.L. Greenberg. 1985. Human bone marrow and peripheral blood T lymphocyte depletion: Efficacy and effects of both T lymphocytes and monocytes on growth of hematopoietic progenitors. Blood 65: 663–679.

    PubMed  CAS  Google Scholar 

  30. Lipton, J.M., and D. Nathan. 1985. Interaction between lymphocytes and macrophages in hematopoiesis. In Hematopoietic Stem Cells. D.W. Golde, and F. Takaku, eds. Marcel Dekker, New York, pp 145–202.

    Google Scholar 

  31. Ebbe, S., and E. Phalen. 1979. Does autoregulation of megakaryocytopoiesis occur? Blood Cells 5: 123–138.

    PubMed  CAS  Google Scholar 

  32. Gewirtz, A.M., and R. Hoffman. 1986. Transitory hypomegakaryocytic thrombocytopenic purpura. Etiologic association with ethanol abuse and implication regarding regulation of human megakaryocytopoiesis. Br. J. Haematol. 62: 333–344.

    Article  PubMed  CAS  Google Scholar 

  33. Katz, I.R., M.K. Hoffmann, M.B. Zucker, M.K. Bell, and G.J. Thorbecke. 1985. A platelet derived immunoregulatory serum factor with T cell affinity. J. Immunol. 134: 3199–3203.

    PubMed  CAS  Google Scholar 

  34. Katz, I.R., G.J. Thorbecke, M.K. Bell, Z. Yin, D. Clarke, and M.B. Zucker. 1986. Protease-induced immunoregulatory activity of platelet factor 4. Proc. Natl. Acad. Sci. USA. 83: 3491–3495.

    Article  PubMed  CAS  Google Scholar 

  35. Geissler, D., G. Konwalinka, C. Peschel, K. Grunewald, R. Odavic, and H. Braunsteiner. 1985. A regulatory role of activated T lymphocytes on human megakaryocytopoiesis. Br. J. Haematol. 60: 233–238.

    Article  PubMed  CAS  Google Scholar 

  36. Geissler, D., L. Lu, E. Bruno, H. Yank, H. Broxmeyer, and R. Hoffman. 1986. The influence of T lymphocyte sub-sets and humoral factors on colony formation by human bone marrow and blood megakaryocyte progenitor cells in vitro. J. Immunol. 137: 2508–2513.

    PubMed  CAS  Google Scholar 

  37. Capitanio, A.M., S. Niewiarowski, B. Rucinski, G.P. Tuszynki, C.S. Cierniewski, D. Hershock, and E. Kornecki. 1985. Interaction of platelet factor 4 with human platelets. Biochem Biophys Acta. 839: 161–173.

    Article  PubMed  CAS  Google Scholar 

  38. Sporn, M.B. and A.B. Roberts. 1985. Autocrine growth factors and cancer. Nature 313: 745–747.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Section of Hematology/Oncology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, 19140, USA

    Alan M. Gewirtz

  2. Section of Hematology/Oncology, Department of Pathology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

    Alan M. Gewirtz

  3. Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, 19140, USA

    Alan M. Gewirtz

Authors
  1. Alan M. Gewirtz
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Editors and Affiliations

  1. Veterans Administration Medical Center, University of Mississippi, Jackson, Mississippi, USA

    Mehdi Tavassoli

  2. Veterans Administration Medical Center, University of Nevada, Reno, Nevada, USA

    Esmail D. Zanjani

  3. New York Medical College, Valhalla, New York, USA

    Joao L. Ascensao  & Nader G. Abraham  & 

  4. Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Alan S. Levine

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© 1988 Plenum Press, New York

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Gewirtz, A.M. (1988). Exogenous and Endogenous Regulations of Human Megakaryocytopoiesis. In: Tavassoli, M., Zanjani, E.D., Ascensao, J.L., Abraham, N.G., Levine, A.S. (eds) Molecular Biology of Hemopoiesis. Advances in Experimental Medicine and Biology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5571-7_18

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  • DOI: https://doi.org/10.1007/978-1-4684-5571-7_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5573-1

  • Online ISBN: 978-1-4684-5571-7

  • eBook Packages: Springer Book Archive

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