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Molecular Implications of Ph (+) Myelodysplastic Syndrome

  • Toyama Keisuke
  • Ohyashiki Kazuma
  • H. Ohyashiki Junko
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)

Abstract

We report a case of 62-year-old Japanese male with a myelodysplastic syndrome (MDS) with a Philadelphia (Ph) chromosome. Cytogenetic analysis revealed the bone marrow cells to contain a Ph chromosome due to t(?;11;22) (?;q11;q11), as well as −5, −7, +8, −12 and an extra Ph, in addition to cells with a normal karyotype. Molecular analysis using breakpoint cluster region probes (5′ bcr and 3′ bcr) did not detect a rearrangement within the bcr DNA sequences, indicating that the breakpoint at 22q11 occurred outside the bcr. Furthermore, the bone marrow cells from this patient did not express an 8.5 kb c-abl mRNA. Thus, the Ph translocation in this case differs from that of Ph-positive chronic myelogenous leukemia.

Keywords

Bone Marrow Cell Myelodysplastic Syndrome Chronic Myelogenous Leukemia Chronic Myelogenous Leukemia Cell Chronic Myelogenous Leukemia Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Toyama Keisuke
    • 1
  • Ohyashiki Kazuma
    • 1
  • H. Ohyashiki Junko
    • 1
  1. 1.Department of Internal MedicineTokyo Medical CollegeShinjuku-ku Tokyo 160Japan

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