Molecular Implications of Ph (+) Myelodysplastic Syndrome

  • Toyama Keisuke
  • Ohyashiki Kazuma
  • H. Ohyashiki Junko
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 34)


We report a case of 62-year-old Japanese male with a myelodysplastic syndrome (MDS) with a Philadelphia (Ph) chromosome. Cytogenetic analysis revealed the bone marrow cells to contain a Ph chromosome due to t(?;11;22) (?;q11;q11), as well as −5, −7, +8, −12 and an extra Ph, in addition to cells with a normal karyotype. Molecular analysis using breakpoint cluster region probes (5′ bcr and 3′ bcr) did not detect a rearrangement within the bcr DNA sequences, indicating that the breakpoint at 22q11 occurred outside the bcr. Furthermore, the bone marrow cells from this patient did not express an 8.5 kb c-abl mRNA. Thus, the Ph translocation in this case differs from that of Ph-positive chronic myelogenous leukemia.


Bone Marrow Cell Myelodysplastic Syndrome Chronic Myelogenous Leukemia Chronic Myelogenous Leukemia Cell Chronic Myelogenous Leukemia Patient 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Toyama Keisuke
    • 1
  • Ohyashiki Kazuma
    • 1
  • H. Ohyashiki Junko
    • 1
  1. 1.Department of Internal MedicineTokyo Medical CollegeShinjuku-ku Tokyo 160Japan

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