Abstract
Blood flow in vivo can be estimated by a variety of methods. This paper is concerned primarily with techniques associated with the injection of a bolus of a radioisotope tracer, making measurements using an external detector of a bolus being delivered to some target organ, and the amount of the tracer within the target organ. In practice such in vivo methods suffer from many problems, not least, in the choice of an appropriate tracer. The total amount of tracer is difficult to estimate as a result of attenuation and scatter. It is not usually possible to estimate arrival of activity directly to the target organ. The data observed are noisy. This paper is primarily concerned with techniques that may be used to handle such data, with the aim of rendering the use of such methods ‘stable’ if not completely precise. A brief discussion of some other single photon methods of estimating cerebral blood flow is included.
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References
P. Meier and K.L. Zierler, On the theory of the indicator dilution method for the measurement of blood flow and volume, J. Appl. Physiol. 6: 731 – 743, (1954).
D. Ingram and R. Block, eds, Tracer techniques in nuclear medicine, in “Mathematic Methods in Medicine”, Wiley, Chichester, 1:361–404, (1984).
K.E. Britton, C.C. Nimmon, T-Y Lee, P.H. Jarritt, M. Granowska, A. Greening A and J.M. McAlister, Carotid and cerebral blood flow, in “Information Processing in Medical Imaging” A.B. Brill ed, Nashville, 499 – 525, (1977).
K. Britton, C. Nimmon, M. Granowska and T. Lee, Regional cerebral flow in cerebro vascular disease: validation of a non invasive quantitative radionuclide technique, in “Information processing in Medical Imaging”, R. Di Paola and E. Kahn eds, INSERM, Paris, 469–487, (1979).
S.Z. Lever, H.D. Burns, T.M. Kervitsky et al, Design, preparation and biodistribution of a Tc-99m triaminedithiol complex to assess regional cerebral blood flow, J. Nucl. Med. 26: 1287 – 1294, (1985).
W.D. Obrist, T.K. Thompson, C.H. King and H.S. Wang HS, Determination of regional cerebral blood flow by inhalation of 133Xe. Circ. Res. 20: 124, (1967).
N.A. Lassen and D.H. Ingvar, Radioisotopic assessment of regional cerebral blood, in “Progress in Nuclear Medicine”, E. Potchen and V.R. McCready eds, Karger, Basle 1:376–409, (1972).
N.A. Lassen, E. Sviensdottir, I. Kanno et al, A fast moving single photon emission tomograph for regional cerebral blood flow studies in man, J. Comput. Assist. Tomogr. 2: 661 – 662, (1978).
D.E. Kuhl, J-L. Barrio, S.C. Huang et al, Quantifying local cerebral blood flow by N-isopropyl-p-[123I]-iodoamphetamine (IMP) tomography, J. Nucl. Med. 23: 196 – 203, (1982).
W.H. Knapp, R. von Kumner and W. Kubler, Imaging of cerebral blood flow to volume distribution using SPECT, J. Nucl. Med. 27: 465 – 470, (1986).
C.M. Coulam, H.R. Warner, E.H. Wood and J.B. Bassingthwaighte, A transfer function analysis of coronary and renal circulation calculated from upstream and downstream indicator dilution curves, Circ. Res. 19: 879 - 890, (1966).
A. Kuruc, A. Treves, A. Parker, C. Cheng and A. Sawan A, Radionuclide angiography: an improved deconvolution technique for improvement after suboptimal bolus injection. Radiology 148: 233 – 238 (1983).
M.E.. Valentinuzzi and E.M. Volachec, Discrete deconvolution, Med. Biol. Eng., 13: 123 – 125, (1975).
J.L. Mohamed and J.E. Walsh JE, eds, “Numerical Algorithms”, Clarendon Press, Oxford, (1986).
K. Godfrey, “Compartmental models and their applications”, Academic Press, New York, (1983).
H. Bererhi, Deconvolution analysis in nuclear medicine, MSc thesis, University of London (1986).
F. Fazio, C. Fieschi, M. Collice et al, Tomographie assessment of cerebral perfusion using a single-photon emitter (Krypton-81m) and a rotating gamma camera, J. Nucl. Med. 21: 1139 – 1145, (1980).
B.L. Holman, R.G.L. Lee, T.C. Hill et al, A comparison of two cerebral perfusion tracers, N-isopropyl I-123 p-iodoamphetamine and I-123 HIPDM in the human, J. Nucl. Med. 25: 25 – 30, (1984).
I. Podreka, E. Suess, G. Goldenberg et al, Initial experiences with Tc-99m hexamethylpropyleneamine oxime (Tc-99m-HMPAO) brain SPECT, J. Nucl. Med. 27: 887 (1986).
A. Todd-Pokropek, G. Clarke and R. Marsh, Preprocessing of SPECT data as a precursor for attenuation correction, in “Information Processing of Medical Images”, F. Deconnink ed, Martinus Nijhoff, Boston, 130 – 150, (1984).
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© 1988 Plenum Press, New York
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Todd-Pokropek, A. (1988). Estimating Blood Flow by Deconvolution of the Injection of Radioisotope Tracers. In: Rescigno, A., Boicelli, A. (eds) Cerebral Blood Flow. NATO ASI Series, vol 153. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5565-6_6
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DOI: https://doi.org/10.1007/978-1-4684-5565-6_6
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