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Basic Principles in Imaging of Regional Cerebral Metabolic Rates with Radioisotopes

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Cerebral Blood Flow

Part of the book series: NATO ASI Series ((NSSA,volume 153))

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Abstract

Radioisotopes are frequently used to facilitate the assay of rates of biochemical reactions. Usually they are used to study chemical reactions in vitro and the procedure is to label one of the reactants and to measure the rate of accumulation of a labeled product. From assay or knowledge of the specific activity of the reactant molecule and the stoichiometry of the reaction the rate of the overall reaction can be calculated from the rate of radioactive product formation. The application of this approach generally necessitates, however, specialized biochemical procedures to identify and isolate the labeled product so as to limit the measurement of the radioactivity to a specific chemical product of the reaction.

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Author information

Authors and Affiliations

  1. Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bldg. 36, Rm. 1A-05, Bethesda, MD, 20892, USA

    Louis Sokoloff

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  1. Louis Sokoloff
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Editor information

Editors and Affiliations

  1. Institute of Experimental and Clinical Medicine, University of Ancona, Ancona, Italy

    Aldo Rescigno

  2. NMR Laboratory, IRCCS San Raffaele, 20132, Milano, Italy

    Andrea Boicelli

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© 1988 Plenum Press, New York

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Sokoloff, L. (1988). Basic Principles in Imaging of Regional Cerebral Metabolic Rates with Radioisotopes. In: Rescigno, A., Boicelli, A. (eds) Cerebral Blood Flow. NATO ASI Series, vol 153. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5565-6_3

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  • DOI: https://doi.org/10.1007/978-1-4684-5565-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5567-0

  • Online ISBN: 978-1-4684-5565-6

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