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Activation of Oncogenes by Chemical Carcinogens

  • Chapter
The Pathobiology of Neoplasia

Abstract

Increasing evidence suggests that a small set of cellular genes appear to be targets for genetic alterations that contribute to the neoplastic transformation of cells. These genes, termed protooncogenes, appear to play a crucial role in normal cellular growth or differentiation since they are highly conserved in nature, being detected in species as divergent as yeast, Drosophila, and humans. Recent identification of a number of these genes as encoding for putative growth factors (sis,hst, int-2), growth factor receptors (neu, erb B, fms), proteins involved in the regulation of transmembrane signal transduction (ras), nuclear regulatory proteins (myc, myb, fos, jun), tyrosine kinases (src) and serine/threonine kinases (raf, mos) has served to substantiate this idea.

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  1. Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA

    Marshall W. Anderson & Steven H. Reynolds

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  1. Marshall W. Anderson
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  1. Department of Pathology, Medical of College of Virginia, Virginia Commonwealth University, 23298, Richmond, Virginia, USA

    Alphonse E. Sirica

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Anderson, M.W., Reynolds, S.H. (1989). Activation of Oncogenes by Chemical Carcinogens. In: Sirica, A.E. (eds) The Pathobiology of Neoplasia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5523-6_15

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